{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:36:03Z","timestamp":1786703763549,"version":"build-2736575974"},"reference-count":72,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM29832"],"award-info":[{"award-number":["GM29832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007890","name":"University of North Carolina at Chapel Hill","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007890","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The expression of metazoan replication-dependent histone genes is controlled by the nuclear protein at the ataxia-telangiectasia locus (NPAT) and U7 small nuclear ribonucleoprotein particle (snRNP). NPAT activates transcription of histone genes during S-phase, whereas U7 snRNP is a multi-subunit endonuclease that cleaves the resultant transcripts at the 3\u2032 end, yielding mature histone mRNAs. In cycling cells, NPAT and U7 snRNP with its four unique components, U7 snRNA, Lsm10, Lsm11 and FLASH, are highly enriched in histone locus bodies (HLBs), the nuclear condensates formed near histone gene loci. Here, we show that in muscle and neural cells that have ceased to replicate their chromatin and permanently exited the cell cycle, HLBs are dismantled and NPAT, FLASH and Lsm11 are detected in the cytoplasm. This observation suggests that in postmitotic cells, NPAT and U7 snRNP become repurposed for functions unrelated to generating histone mRNAs. We identified a highly conserved region in Lsm11 that engages in various protein\u2013protein interactions and likely acts as a universal platform that controls the assembly, localization and function of Lsm11 complexes, including U7 snRNP, during cell growth and differentiation. Since the assembly of U7 snRNP requires survival motor neuron, the protein mutated in spinal muscular atrophy, our results may provide a new perspective on the pathophysiology of this neuromuscular disorder.<\/jats:p>","DOI":"10.1242\/bio.062755","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:56:33Z","timestamp":1785761793000},"source":"Crossref","is-referenced-by-count":0,"title":["Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells?"],"prefix":"10.1242","volume":"15","author":[{"given":"Xiao-Cui","family":"Yang","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill 1 Integrative Program for Biological and Genome Sciences , , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-3152","authenticated-orcid":false,"given":"Anthony","family":"Desotell","sequence":"additional","affiliation":[{"name":"Columbia University 2 Department of Biological Sciences , , New York, NY 10027 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6599-901X","authenticated-orcid":false,"given":"Agata","family":"Malinowska","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences 3 Department of Biophysics , , 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Basundra","sequence":"additional","affiliation":[{"name":"Neuroscience Center, University of North Carolina at Chapel Hill 4 , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-718X","authenticated-orcid":false,"given":"Gautam K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill 5 Department of Genetics , , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-153X","authenticated-orcid":false,"given":"Karen L.","family":"Mohlke","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill 5 Department of Genetics , , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanish","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Neuroscience Center, University of North Carolina at Chapel Hill 4 , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Dadlez","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences 3 Department of Biophysics , , 02-106 Warsaw ,","place":["Poland"]},{"name":"Institute of Genetics and Biotechnology, Warsaw University 6 , 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-6468","authenticated-orcid":false,"given":"Liang","family":"Tong","sequence":"additional","affiliation":[{"name":"Columbia University 2 Department of Biological Sciences , , New York, NY 10027 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-7796","authenticated-orcid":false,"given":"Zbigniew","family":"Dominski","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill 1 Integrative Program for Biological and Genome Sciences , , Chapel Hill, NC 27599 ,","place":["USA"]},{"name":"University of North Carolina at Chapel Hill 7 Department of Biochemistry and Biophysics , , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"2026081406095669800_BIO062755C1","doi-asserted-by":"publisher","first-page":"e0186034","DOI":"10.1371\/journal.pone.0186034","article-title":"The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing","volume":"12","author":"Aik","year":"2017","journal-title":"PLoS ONE"},{"key":"2026081406095669800_BIO062755C2","doi-asserted-by":"publisher","first-page":"14802","DOI":"10.1073\/pnas.0604225103","article-title":"FLASH is an essential component of Cajal bodies","volume":"103","author":"Barcaroli","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026081406095669800_BIO062755C3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1101\/sqb.2006.71.001","article-title":"The SMN complex: an assembly machine for RNPs","volume":"71","author":"Battle","year":"2006","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"2026081406095669800_BIO062755C4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainres.2018.02.022","article-title":"Spinal muscular atrophy","volume":"1693","author":"Beattie","year":"2018","journal-title":"Brain Res."},{"key":"2026081406095669800_BIO062755C5","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1101\/gad.5.9.1709","article-title":"Multiple processing-defective mutations in a mammalian histone premessenger RNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro","volume":"5","author":"Bond","year":"1991","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C6","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.4161\/cc.6344","article-title":"FLASH and NPAT positive but not Coilin positive Cajal","volume":"7","author":"Bongiorno-Borbone","year":"2008","journal-title":"Cell Cycle"},{"key":"2026081406095669800_BIO062755C7","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1093\/nar\/gkz1148","article-title":"Composition and processing activity of a semi-recombinant holo U7 snRNP","volume":"48","author":"Bucholc","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2026081406095669800_BIO062755C8","doi-asserted-by":"publisher","first-page":"5268","DOI":"10.3390\/ijms21155268","article-title":"Structural analysis of the SANT\/Myb","volume":"21","author":"Bucholc","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026081406095669800_BIO062755C9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1261\/rna.2566811","article-title":"Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in","volume":"17","author":"Burch","year":"2011","journal-title":"RNA"},{"key":"2026081406095669800_BIO062755C10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","author":"Burghes","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"2026081406095669800_BIO062755C11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuron.2010.09.022","article-title":"Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons","volume":"68","author":"Cai","year":"2010","journal-title":"Neuron"},{"key":"2026081406095669800_BIO062755C12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cell.2008.09.020","article-title":"An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs","volume":"135","author":"Chari","year":"2008","journal-title":"Cell"},{"key":"2026081406095669800_BIO062755C13","doi-asserted-by":"publisher","first-page":"28476","DOI":"10.1074\/jbc.M414328200","article-title":"Tudor domains bind symmetrical dimethylated arginines","volume":"280","author":"Cote","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2026081406095669800_BIO062755C14","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1016\/j.cell.2021.05.008","article-title":"DMA","volume":"184","author":"Courchaine","year":"2021","journal-title":"Cell"},{"key":"2026081406095669800_BIO062755C15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(99)00367-4","article-title":"Formation of the 3","volume":"239","author":"Dominski","year":"1999","journal-title":"Gene"},{"key":"2026081406095669800_BIO062755C16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.gene.2007.04.021","article-title":"Formation of the 3","volume":"396","author":"Dominski","year":"2007","journal-title":"Gene"},{"key":"2026081406095669800_BIO062755C17","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1042\/BST20210323","article-title":"U7 deciphered: the mechanism that forms the unusual 3","volume":"49","author":"Dominski","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"2026081406095669800_BIO062755C18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2005.08.002","article-title":"The","volume":"123","author":"Dominski","year":"2005","journal-title":"Cell"},{"key":"2026081406095669800_BIO062755C19","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1080\/15476286.2016.1265198","article-title":"Coordinating cell cycle-regulated histone gene expression through assembly and function of the","volume":"14","author":"Duronio","year":"2017","journal-title":"RNA Biol."},{"key":"2026081406095669800_BIO062755C20","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/j.1460-2075.1993.tb05689.x","article-title":"Nucleo-cytoplasmic transport of U snRNPs","volume":"12","author":"Fischer","year":"1993","journal-title":"EMBO J."},{"key":"2026081406095669800_BIO062755C21","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.neuron.2009.03.029","article-title":"Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity","volume":"62","author":"Frank","year":"2009","journal-title":"Neuron"},{"key":"2026081406095669800_BIO062755C22","doi-asserted-by":"publisher","first-page":"16964","DOI":"10.1073\/pnas.0809273105","article-title":"Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells","volume":"105","author":"Ghule","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026081406095669800_BIO062755C23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00412-017-0637-6","article-title":"UsnRNP biogenesis: mechanisms and regulation","volume":"126","author":"Gruss","year":"2017","journal-title":"Chromosoma"},{"key":"2026081406095669800_BIO062755C24","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1101\/gad.352728.125","article-title":"SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly","volume":"39","author":"He","year":"2025","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C25","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nrm.2016.27","article-title":"Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases","volume":"17","author":"Hydbring","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026081406095669800_BIO062755C26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/5673","article-title":"Snapin: a SNARE-associated protein implicated in synaptic transmission","volume":"2","author":"Ilardi","year":"1999","journal-title":"Nat. Neurosci."},{"key":"2026081406095669800_BIO062755C27","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2026081406095669800_BIO062755C28","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.tibs.2005.07.006","article-title":"LSm proteins form heptameric rings that bind to RNA via repeating motifs","volume":"30","author":"Khusial","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"2026081406095669800_BIO062755C29","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.neuron.2023.02.004","article-title":"A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses","volume":"111","author":"Kim","year":"2023","journal-title":"Neuron"},{"key":"2026081406095669800_BIO062755C30","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1101\/gad.829500","article-title":"Cell cycle-regulated phosphorylation of p220NPAT by cyclin E\/Cdk2 in Cajal bodies promotes histone gene transcription","volume":"14","author":"Ma","year":"2000","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C31","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nature05363","article-title":"Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease","volume":"444","author":"Mandel","year":"2006","journal-title":"Nature"},{"key":"2026081406095669800_BIO062755C32","doi-asserted-by":"publisher","first-page":"iyae223","DOI":"10.1093\/genetics\/iyae223","article-title":"Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex","volume":"229","author":"Matera","year":"2025","journal-title":"Genetics"},{"key":"2026081406095669800_BIO062755C33","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.devcel.2009.10.017","article-title":"Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?","volume":"17","author":"Matera","year":"2009","journal-title":"Dev. Cell"},{"key":"2026081406095669800_BIO062755C34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nrm2124","article-title":"Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs","volume":"8","author":"Matera","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026081406095669800_BIO062755C35","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-cellbio-030123-032748","article-title":"The tubulin code, from molecules to health and disease","volume":"39","author":"McKenna","year":"2023","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2026081406095669800_BIO062755C36","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.neuron.2005.12.001","article-title":"Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease","volume":"48","author":"Monani","year":"2005","journal-title":"Neuron"},{"key":"2026081406095669800_BIO062755C37","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1016\/j.febslet.2008.03.009","article-title":"Deciphering the assembly pathway of Sm-class U snRNPs","volume":"582","author":"Neuenkirchen","year":"2008","journal-title":"FEBS Lett."},{"key":"2026081406095669800_BIO062755C38","doi-asserted-by":"publisher","first-page":"a000653","DOI":"10.1101\/cshperspect.a000653","article-title":"The Cajal body and histone locus body","volume":"2","author":"Nizami","year":"2010","journal-title":"Cold Spring Harb. Perspect Biol."},{"key":"2026081406095669800_BIO062755C39","doi-asserted-by":"publisher","first-page":"1016071","DOI":"10.3389\/fmolb.2022.1016071","article-title":"Structural insights into the functional roles of 14-3-3 proteins","volume":"9","author":"Obsilova","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"2026081406095669800_BIO062755C40","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1016\/j.celrep.2016.08.047","article-title":"The ribosome cooperates with the assembly chaperone pICln to","volume":"16","author":"Paknia","year":"2016","journal-title":"Cell Rep."},{"key":"2026081406095669800_BIO062755C41","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1101\/gad.274403","article-title":"Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing","volume":"17","author":"Pillai","year":"2003","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/323777a0","article-title":"Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3","volume":"323","author":"Schaufele","year":"1986","journal-title":"Nature"},{"key":"2026081406095669800_BIO062755C43","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1007\/s00018-004-4190-0","article-title":"The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein","volume":"61","author":"Schumperli","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"2026081406095669800_BIO062755C44","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.molcel.2023.02.018","article-title":"A central chaperone-like role for 14-3-3 proteins in human cells","volume":"83","author":"Segal","year":"2023","journal-title":"Mol. Cell"},{"key":"2026081406095669800_BIO062755C45","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.tibs.2023.04.003","article-title":"Tudor-dimethylarginine interactions: the condensed version","volume":"48","author":"Simcikova","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"2026081406095669800_BIO062755C46","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.jmb.2016.01.031","article-title":"Mapping the interaction network of key proteins involved in histone mRNA generation: a hydrogen\/deuterium exchange study","volume":"428","author":"Skrajna","year":"2016","journal-title":"J. Mol. Biol."},{"key":"2026081406095669800_BIO062755C47","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1093\/nar\/gky133","article-title":"Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker","volume":"46","author":"Skrajna","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2026081406095669800_BIO062755C48","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/febs.13986","article-title":"Moonlighting chaperone-like activity of the universal regulatory 14-3-3 proteins","volume":"284","author":"Sluchanko","year":"2017","journal-title":"FEBS J."},{"key":"2026081406095669800_BIO062755C49","doi-asserted-by":"publisher","first-page":"9784","DOI":"10.1073\/pnas.88.21.9784","article-title":"Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2","volume":"88","author":"Smith","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026081406095669800_BIO062755C50","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/sj.emboj.7600163","article-title":"MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay","volume":"23","author":"Stoecklin","year":"2004","journal-title":"EMBO J."},{"key":"2026081406095669800_BIO062755C51","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1126\/science.1161748","article-title":"Membrane fusion: grappling with SNARE and SM proteins","volume":"323","author":"Sudhof","year":"2009","journal-title":"Science"},{"key":"2026081406095669800_BIO062755C52","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1126\/science.aaz7758","article-title":"Structure of an active human histone pre-mRNA 3","volume":"367","author":"Sun","year":"2020","journal-title":"Science"},{"key":"2026081406095669800_BIO062755C53","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/bs.mie.2021.03.021","article-title":"Reconstitution and biochemical assays of an active human histone pre-mRNA 3","volume":"655","author":"Sun","year":"2021","journal-title":"Methods Enzymol."},{"key":"2026081406095669800_BIO062755C54","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1083\/jcb.201504043","article-title":"Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis","volume":"213","author":"Tatomer","year":"2016","journal-title":"J. Cell Biol."},{"key":"2026081406095669800_BIO062755C55","doi-asserted-by":"publisher","first-page":"10546","DOI":"10.1523\/JNEUROSCI.3275-05.2005","article-title":"The role of Snapin in neurosecretion","volume":"25","author":"Tian","year":"2005","journal-title":"J. Neurosci."},{"key":"2026081406095669800_BIO062755C56","doi-asserted-by":"publisher","first-page":"8691","DOI":"10.1523\/JNEUROSCI.0417-15.2015","article-title":"Disease mechanisms and therapeutic approaches in spinal muscular atrophy","volume":"35","author":"Tisdale","year":"2015","journal-title":"J. Neurosci."},{"key":"2026081406095669800_BIO062755C57","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.celrep.2013.11.012","article-title":"SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3","volume":"5","author":"Tisdale","year":"2013","journal-title":"Cell Rep."},{"key":"2026081406095669800_BIO062755C58","doi-asserted-by":"publisher","first-page":"111393","DOI":"10.1016\/j.celrep.2022.111393","article-title":"SMN controls neuromuscular junction integrity through U7 snRNP","volume":"40","author":"Tisdale","year":"2022","journal-title":"Cell Rep."},{"key":"2026081406095669800_BIO062755C59","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nsmb.2185","article-title":"Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins","volume":"18","author":"Tripsianes","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2026081406095669800_BIO062755C60","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/s41588-020-00737-3","article-title":"cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing","volume":"52","author":"Uggenti","year":"2020","journal-title":"Nat. Genet."},{"key":"2026081406095669800_BIO062755C61","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1261\/rna.080491.125","article-title":"Proteins that recognize unique features of U7 snRNA and may substitute for Gemin5 in the assembly of U7-specific Sm ring","volume":"31","author":"Yang","year":"2025","journal-title":"RNA"},{"key":"2026081406095669800_BIO062755C62","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.molcel.2009.08.016","article-title":"FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3","volume":"36","author":"Yang","year":"2009","journal-title":"Mol. Cell"},{"key":"2026081406095669800_BIO062755C63","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1128\/MCB.00979-10","article-title":"FLASH is required for the endonucleolytic cleavage of histone pre-mRNAs but is dispensable for the 5","volume":"31","author":"Yang","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"2026081406095669800_BIO062755C64","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1128\/MCB.00653-12","article-title":"A","volume":"33","author":"Yang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"2026081406095669800_BIO062755C65","doi-asserted-by":"publisher","first-page":"33767","DOI":"10.1074\/jbc.M114.616466","article-title":"A conserved interaction that is essential for the biogenesis of histone locus bodies","volume":"289","author":"Yang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2026081406095669800_BIO062755C66","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1261\/rna.076273.120","article-title":"Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5","volume":"26","author":"Yang","year":"2020","journal-title":"RNA"},{"key":"2026081406095669800_BIO062755C67","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1261\/rna.079709.123","article-title":"In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5\/MEP50\/pICln methylosome","volume":"29","author":"Yang","year":"2023","journal-title":"RNA"},{"key":"2026081406095669800_BIO062755C68","doi-asserted-by":"publisher","first-page":"R397","DOI":"10.1016\/j.cub.2018.01.005","article-title":"SNARE complex assembly and disassembly","volume":"28","author":"Yoon","year":"2018","journal-title":"Curr. Biol."},{"key":"2026081406095669800_BIO062755C69","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cell.2011.06.043","article-title":"Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly","volume":"146","author":"Zhang","year":"2011","journal-title":"Cell"},{"key":"2026081406095669800_BIO062755C70","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1101\/gad.12.4.456","article-title":"Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry","volume":"12","author":"Zhao","year":"1998","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C71","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1101\/gad.827700","article-title":"NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription","volume":"14","author":"Zhao","year":"2000","journal-title":"Genes Dev."},{"key":"2026081406095669800_BIO062755C72","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1474-9726.2007.00306.x","article-title":"Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies","volume":"6","author":"Zhu","year":"2007","journal-title":"Aging Cell"}],"container-title":["Biology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062755\/3711277\/bio062755.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062755\/3712596\/bio062755.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/bio\/article-pdf\/doi\/10.1242\/bio.062755\/3712596\/bio062755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:10:02Z","timestamp":1786702202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/bio\/article\/15\/8\/bio062755\/372576\/Are-components-of-the-histone-gene-expression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,15]]}},"URL":"https:\/\/doi.org\/10.1242\/bio.062755","relation":{},"ISSN":["2046-6390"],"issn-type":[{"value":"2046-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"article-number":"bio062755"}}