{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:03:36Z","timestamp":1790327016542,"version":"4.1.0"},"reference-count":33,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Michigan State University","id":[{"id":"https:\/\/ror.org\/05hs6h993","id-type":"ROR","asserted-by":"crossref"}]},{"name":"U.S. Department of Agriculture","award":["97-35302-5304"],"award-info":[{"award-number":["97-35302-5304"]}],"id":[{"id":"https:\/\/ror.org\/035q7re19","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Michigan Department of Agriculture and Rural Development","id":[{"id":"https:\/\/ror.org\/023cd6641","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Michigan Beekeepers Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parasites can profoundly alter host behavior, yet the physiological mechanisms underlying these changes are often unclear. In honey bees (Apis mellifera), microsporidian infection has long been associated with precocious foraging, a life-history shift that can destabilize colony function. Here, we identify the endocrine mechanism linking infection to behavioral maturation. Using Nosema apis, we show that infected workers initiate foraging significantly earlier than controls across four colonies (hazard ratio=2.69, P&amp;lt;0.001). This behavioral acceleration was accompanied by a \u223c1.7-fold increase in circulating juvenile hormone (JH) titers, an \u223c83% increase in JH biosynthesis by the corpora allata (CA), and increased in vivo JH metabolism, causing elevated JH turnover during infection. Crucially, surgical removal of the CA eliminated the significant effect of infection on foraging, supporting the hypothesis that activation of this gland contributes to the behavioral effects of infection. Together, these results reveal that microsporidian infection accelerates honey bee behavioral maturation by increasing JH turnover through activation of the CA.<\/jats:p>","DOI":"10.1242\/bio.062830","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:29:49Z","timestamp":1789637389000},"source":"Crossref","is-referenced-by-count":0,"title":["Altered juvenile hormone dynamics mediate earlier foraging in\n                    <i>Nosema<\/i>\n                    -infected honey bees"],"prefix":"10.1242","volume":"15","author":[{"given":"Huarong","family":"Lin","sequence":"first","affiliation":[{"name":"Michigan State University 1 Department of Entomology , , East Lansing, MI 48824 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sullivan","sequence":"additional","affiliation":[{"name":"2 Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Webster","sequence":"additional","affiliation":[{"name":"College of Agriculture, Health and Natural Resources, Kentucky State University 3 , Frankfort, KY 40601 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-5547","authenticated-orcid":false,"given":"Zachary Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Michigan State University 1 Department of Entomology , , East Lansing, MI 48824 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026092504170462000_BIO062830C1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1242\/jeb.073601","article-title":"Parasites: evolution's neurobiologists","volume":"216","author":"Adamo","year":"2013","journal-title":"J. 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