{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:16:39Z","timestamp":1778044599518,"version":"3.51.4"},"reference-count":58,"publisher":"The Company of Biologists","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:p>In Drosophila, trunk visceral mesoderm, a derivative of dorsal mesoderm, gives rise to circular visceral muscles. It has been demonstrated that the trunk visceral mesoderm parasegment is subdivided into at least two domains by connectin expression, which is regulated by Hedgehog and Wingless emanating from the ectoderm. We now extend these findings by examining a greater number of visceral mesodermal genes, includinghedgehog and branchless. Each visceral mesodermal parasegment appears to be divided into five or six regions, based on differences in expression patterns of these genes. Ectodermal Hedgehog and Wingless differentially regulate the expression of these metameric targets in trunk visceral mesoderm. hedgehog expression in trunk visceral mesoderm is responsible for maintaining its own expression and conexpression. hedgehog expressed in visceral mesoderm parasegment 3 may also be required for normal decapentaplegic expression in this region and normal gastric caecum development. branchless expressed in each trunk visceral mesodermal parasegment serves as a guide for the initial budding of tracheal visceral branches. The metameric pattern of trunk visceral mesoderm, organized in response to ectodermal instructive signals, is thus maintained at a later time via autoregulation, is required for midgut morphogenesis and exerts feedback effect on trachea, ectodermal derivatives.<\/jats:p>","DOI":"10.1242\/dev.00242","type":"journal-article","created":{"date-parts":[[2003,1,6]],"date-time":"2003-01-06T23:31:09Z","timestamp":1041895869000},"page":"439-449","source":"Crossref","is-referenced-by-count":11,"title":["Functional subdivision of trunk visceral mesoderm parasegments in<i>Drosophila<\/i>is required for gut and trachea development"],"prefix":"10.1242","volume":"130","author":[{"given":"Chie","family":"Hosono","sequence":"first","affiliation":[{"name":"Department of Biophysics and Biochemistry, Graduate School of Science,University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Takaira","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biochemistry, Graduate School of Science,University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biochemistry, Graduate School of Science,University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Saigo","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biochemistry, Graduate School of Science,University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042604315468800_REF1","unstructured":"Alcedo, J. and Noll, M. 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