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These guidance defects are similar to those observed in integrin mutants, and genetic analysis shows that integrins function together with Cas to facilitate axonal defasciculation. These results strongly support Cas proteins working together with integrins in vivo to direct axon guidance events.<\/jats:p>","DOI":"10.1242\/dev.004242","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T19:48:32Z","timestamp":1180554512000},"page":"2337-2347","source":"Crossref","is-referenced-by-count":34,"title":["Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development"],"prefix":"10.1242","volume":"134","author":[{"given":"Zhiyu","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Basic Neuroscience, Department of Pharmacology, NA4.301\/5323 Harry Hines Blvd, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Center for Basic Neuroscience, Department of Pharmacology, NA4.301\/5323 Harry Hines Blvd, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Thompson-Peer","sequence":"additional","affiliation":[{"name":"Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute,The Johns Hopkins University School of Medicine, 725 North Wolfe Street,Baltimore, MD 21205, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex L.","family":"Kolodkin","sequence":"additional","affiliation":[{"name":"Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute,The Johns Hopkins University School of Medicine, 725 North Wolfe Street,Baltimore, MD 21205, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Terman","sequence":"additional","affiliation":[{"name":"Center for Basic Neuroscience, Department of Pharmacology, NA4.301\/5323 Harry Hines Blvd, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042612232871800_REF1","doi-asserted-by":"crossref","unstructured":"Adams, D. N., Kao, E. Y., Hypolite, C. 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