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Although the location of cell division is disorganized in embryos with reduced or no Ncad function, different classes of retinal neurons are generated. However, these neurons fail to organize into correct laminae, most probably owing to compromised adhesion between retinal cells. In addition, amacrine cells exhibit exuberant and misdirected outgrowth of neurites that contributes to severe disorganization of the inner plexiform layer. Retinal ganglion cells also exhibit defects in process outgrowth, with axons exhibiting fasciculation defects and adopting incorrect ipsilateral trajectories. At least some of these defects are likely to be due to a failure to maintain compartment boundaries between eye, optic nerve and brain. Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function.<\/jats:p>","DOI":"10.1242\/dev.00465","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T12:48:41Z","timestamp":1050583721000},"page":"2479-2494","source":"Crossref","is-referenced-by-count":250,"title":["N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites"],"prefix":"10.1242","volume":"130","author":[{"given":"Ichiro","family":"Masai","sequence":"first","affiliation":[{"name":"Masai Initiative Research Unit, The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Lele","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology, University College London,Gower Street, London WC1E 6BT, UK"},{"name":"Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Masai Initiative Research Unit, The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Komori","sequence":"additional","affiliation":[{"name":"Masai Initiative Research Unit, The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Nakata","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation (JST), Hirosawa 2-1,Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nishiwaki","sequence":"additional","affiliation":[{"name":"Masai Initiative Research Unit, The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Wada","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation (JST), Hirosawa 2-1,Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideomi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation (JST), Hirosawa 2-1,Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nojima","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation (JST), Hirosawa 2-1,Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hammerschmidt","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology, University College London,Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation (JST), Hirosawa 2-1,Wako-shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604283658100_REF1","doi-asserted-by":"crossref","unstructured":"Bassnett, S., Missey, H. and Vucemilo, I.(1999). 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