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Homologous introduction of cre recombinase into the Dermo1 (Twist2) gene locus resulted in robust expression of CRE in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages. Inactivation of a floxed Fgfr2 allele with Dermo1-cre resulted in mice with skeletal dwarfism and decreased bone density. Although differentiation of the osteoblast lineage was not disturbed,the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected.<\/jats:p>","DOI":"10.1242\/dev.00491","type":"journal-article","created":{"date-parts":[[2003,5,20]],"date-time":"2003-05-20T00:21:48Z","timestamp":1053390108000},"page":"3063-3074","source":"Crossref","is-referenced-by-count":591,"title":["Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth"],"prefix":"10.1242","volume":"130","author":[{"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S. 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