{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:59:35Z","timestamp":1791039575949,"version":"4.1.0"},"reference-count":66,"publisher":"The Company of Biologists","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,15]]},"abstract":"<jats:p>In C. elegans, the RAS\/MAPK pathway is used in different tissues to regulate various cell fate decisions. Several positive and negative regulators tightly control the activity of the RAS\/MAPK pathway at different steps. We demonstrate a link between a G-protein-coupled receptor signalling pathway and the RAS\/MAPK cascade. SRA-13, a member of the SRA family of chemosensory receptors, negatively regulates RAS\/MAPK signalling during vulval induction and the olfaction of volatile attractants. Epistasis analysis indicates that SRA-13 inhibits the RAS\/MAPK pathway at the level or upstream of MAPK. In both tissues, the vulval precursor cells and the chemosensory neurones, SRA-13 acts through the GPA-5 G\u03b1 protein subunit, suggesting a common mechanism of crosstalk. Moreover, we find that vulval induction is repressed by food withdrawal during larval development and that SRA-13 activity is required for the suppression of vulval induction in response to food starvation. Thus, SRA-13 may serve to adapt the activity of the RAS\/MAPK pathway to environmental conditions.<\/jats:p>","DOI":"10.1242\/dev.00497","type":"journal-article","created":{"date-parts":[[2003,5,7]],"date-time":"2003-05-07T21:48:46Z","timestamp":1052344126000},"page":"2567-2577","source":"Crossref","is-referenced-by-count":34,"title":["The<i>C. elegans<\/i>G-protein-coupled receptor SRA-13 inhibits RAS\/MAPK signalling during olfaction and vulval development"],"prefix":"10.1242","volume":"130","author":[{"given":"Gopal","family":"Battu","sequence":"first","affiliation":[{"name":"Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Froehli","family":"Hoier","sequence":"additional","affiliation":[{"name":"Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042611464117100_REF1","doi-asserted-by":"crossref","unstructured":"Bargmann, C. 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