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The development and differentiation of many neurons require the gene zag-1, which encodes a \u03b4EF1\/ZFH-1 Zn-finger-homeodomain protein. zag-1 mutations cause misexpression of neuron-specific genes, block formation of stereotypic axon branches, perturb neuronal migrations, and induce various axon-guidance, fasciculation and branching errors. A zag-1-GFP translational reporter is expressed transiently in most or all neurons during embryogenesis and in select neurons during the first larval stage. Analysis of the zag-1 promoter reveals that zag-1 is expressed in neurons and specific muscles, and that ZAG-1 directly represses its own expression. zag-1 activity also downregulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. We propose that ZAG-1 acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression.<\/jats:p>","DOI":"10.1242\/dev.00571","type":"journal-article","created":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T23:54:27Z","timestamp":1057017267000},"page":"3781-3794","source":"Crossref","is-referenced-by-count":119,"title":["<i>C. elegans<\/i>ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation"],"prefix":"10.1242","volume":"130","author":[{"given":"Scott G.","family":"Clark","sequence":"first","affiliation":[{"name":"Molecular Neurobiology Program, Department of Pharmacology, Skirball Institute, NYU School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chiu","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Program, Department of Pharmacology, Skirball Institute, NYU School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042611500646200_REF1","unstructured":"Baran, R., Aronoff, R. and Garriga, G. 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