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Loss of Kette protein results in the accumulation of cytosolic F-actin. The kette mutant phenotype can be suppressed by reducing the wave gene dose, demonstrating that kette antagonizes wave function. Overexpression of the wild-type Kette protein does not interfere with normal development, whereas expression of an activated,membrane-tethered Kette protein induces the formation of large F-actin bundles in both, tissue culture cells and in vivo. This gain-of-function phenotype is independent of wave but can be suppressed by reducing the wasp gene dose, indicating that Kette is able to regulate Wasp, to which it is linked via the Abelson interactor (Abi). Our data suggest a model where Kette fulfils a novel role in regulating F-actin organization by antagonizing Wave and activating Wasp-dependent actin polymerization.<\/jats:p>","DOI":"10.1242\/dev.00663","type":"journal-article","created":{"date-parts":[[2003,8,6]],"date-time":"2003-08-06T16:43:51Z","timestamp":1060188231000},"page":"4427-4437","source":"Crossref","is-referenced-by-count":74,"title":["Kette regulates actin dynamics and genetically interacts with Wave and Wasp"],"prefix":"10.1242","volume":"130","author":[{"given":"Sven","family":"Bogdan","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster, Badestr. 9, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kla\u0308mbt","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster, Badestr. 9, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604353439100_REF1","doi-asserted-by":"crossref","unstructured":"Adler, C. 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