{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:46:20Z","timestamp":1791060380613,"version":"4.1.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,15]]},"abstract":"<jats:p>The van gogh (vgo) mutant in zebrafish is characterized by defects in the ear, pharyngeal arches and associated structures such as the thymus. We show that vgo is caused by a mutation in tbx1, a member of the large family of T-box genes. tbx1 has been recently suggested to be a major contributor to the cardiovascular defects in DiGeorge deletion syndrome (DGS) in humans, a syndrome in which several neural crest derivatives are affected in the pharyngeal arches. Using cell transplantation studies, we demonstrate that vgo\/tbx1 acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. Furthermore, we provide evidence for regulatory interactions between vgo\/tbx1 and edn1 and hand2,genes that are implicated in the control of pharyngeal arch development and in the etiology of DGS.<\/jats:p>","DOI":"10.1242\/dev.00704","type":"journal-article","created":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T12:21:48Z","timestamp":1062505308000},"page":"5043-5052","source":"Crossref","is-referenced-by-count":198,"title":["The zebrafish\n                    <i>van gogh<\/i>\n                    mutation disrupts\n                    <i>tbx1<\/i>\n                    , which is involved in the DiGeorge deletion syndrome in humans"],"prefix":"10.1242","volume":"130","author":[{"given":"Tatjana","family":"Piotrowski","sequence":"first","affiliation":[{"name":"National Institutes of Health, NICHD, LMG, Bldg. 6B, 9000 Rockville Pike,Bethesda, MD 20892, USA"},{"name":"University of Utah, Department of Neurobiology and Anatomy, 401 MREB, Salt Lake City, UT 84132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-gwon","family":"Ahn","sequence":"additional","affiliation":[{"name":"University of Chicago, Department of Organismal Biology and Anatomy, Chicago,IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Schilling","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Department of Developmental and Cell Biology, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreelaja","family":"Nair","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Department of Developmental and Cell Biology, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Ruvinsky","sequence":"additional","affiliation":[{"name":"Princeton University, Department of Molecular Biology, Princeton, NJ 08544,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Geisler","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Developmental Biology, Spemannstr.35, 72076,Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Jo\u0308rg","family":"Rauch","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Developmental Biology, Spemannstr.35, 72076,Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Haffter","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Developmental Biology, Spemannstr.35, 72076,Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard I.","family":"Zon","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Hematology\/Oncology, Children's Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Hematology\/Oncology, Children's Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Foott","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Hematology\/Oncology, Children's Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor B.","family":"Dawid","sequence":"additional","affiliation":[{"name":"National Institutes of Health, NICHD, LMG, Bldg. 6B, 9000 Rockville Pike,Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Ho","sequence":"additional","affiliation":[{"name":"University of Chicago, Department of Organismal Biology and Anatomy, Chicago,IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042611551933800_REF1","doi-asserted-by":"crossref","unstructured":"Angelo, S., Lohr, J., Lee, K. H., Ticho, B. S., Breitbart, R. E., Hill, S., Yost, H. J. and Srivastava, D. (2000). Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech. Dev.95,231-237.","DOI":"10.1016\/S0925-4773(00)00334-8"},{"key":"2021042611551933800_REF2","doi-asserted-by":"crossref","unstructured":"Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. C., Krakowiak,P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, L. B., Gebuhr, T. C. et al. (1997). Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat. Genet.16,311-315.","DOI":"10.1038\/ng0797-311"},{"key":"2021042611551933800_REF3","doi-asserted-by":"crossref","unstructured":"Basson, C. T., Bachinsky, D. R., Lin, R. C., Levi, T., Elkins,J. A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T. A.,Leblanc-Straceski, J. et al. (1997). Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nat. Genet.15,30-35.","DOI":"10.1038\/ng0197-30"},{"key":"2021042611551933800_REF4","doi-asserted-by":"crossref","unstructured":"Carreira, S., Dexter, T. J., Yavuzer, U., Easty, D. J. and Goding, C. R. (1998). Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. Mol. Cell Biol.18,5099-5108.","DOI":"10.1128\/MCB.18.9.5099"},{"key":"2021042611551933800_REF5","doi-asserted-by":"crossref","unstructured":"Charite, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A. and Olson, E. N.(2001). Role of Dlx6 in regulation of an endothelin-1-dependent,dHAND branchial arch enhancer. Genes Dev.15,3039-3049.","DOI":"10.1101\/gad.931701"},{"key":"2021042611551933800_REF6","doi-asserted-by":"crossref","unstructured":"David, N. B. and Rosa, F. M. (2001). Cell autonomous commitment to an endodermal fate and behaviour by activation of Nodal signalling. Development128,3937-3947.","DOI":"10.1242\/dev.128.20.3937"},{"key":"2021042611551933800_REF7","doi-asserted-by":"crossref","unstructured":"David, N. B., Saint-Etienne, L., Tsang, M., Schilling, T. F. and Rosa, F. M. (2002). Requirement for endoderm and FGF3 in ventral head skeleton formation. Development129,4457-4468.","DOI":"10.1242\/dev.129.19.4457"},{"key":"2021042611551933800_REF8","unstructured":"Frank, D. U., Fotheringham, L. K., Brewer, J. A., Muglia, L. J.,Tristani-Firouzi, M., Capecchi, M. R. and Moon, A. M. (2002). An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development129,4591-4603."},{"key":"2021042611551933800_REF9","doi-asserted-by":"crossref","unstructured":"Funke, B., Epstein, J. A., Kochilas, L. K., Lu, M. M., Pandita,R. K., Liao, J., Bauerndistel, R., Schuler, T., Schorle, H., Brown, M. C. et al. (2001). Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome\/DiGeorge syndrome have middle and inner ear defects. Hum. Mol. Genet.10,2549-2556.","DOI":"10.1093\/hmg\/10.22.2549"},{"key":"2021042611551933800_REF10","doi-asserted-by":"crossref","unstructured":"Furthauer, M., Thisse, C. and Thisse, B.(1997). A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development124,4253-4264.","DOI":"10.1242\/dev.124.21.4253"},{"key":"2021042611551933800_REF11","doi-asserted-by":"crossref","unstructured":"Garg, V., Yamagishi, C., Hu, T., Kathiriya, I. S., Yamagishi, H. and Srivastava, D. (2001). Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev. Biol.235, 62-73.","DOI":"10.1006\/dbio.2001.0283"},{"key":"2021042611551933800_REF12","doi-asserted-by":"crossref","unstructured":"Griffin, K. J., Amacher, S. L., Kimmel, C. B. and Kimelman,D. (1998). Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development125,3379-3388.","DOI":"10.1242\/dev.125.17.3379"},{"key":"2021042611551933800_REF13","doi-asserted-by":"crossref","unstructured":"Haffter, P., Granato, M., Brand, M., Mullins, M. C.,Hammerschmidt, M., Kane, D. A., Odenthal, J., van Eeden, F. J., Jiang, Y. J.,Heisenberg, C. P. et al. (1996). The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development123,1-36.","DOI":"10.1242\/dev.123.1.1"},{"key":"2021042611551933800_REF14","doi-asserted-by":"crossref","unstructured":"Hatcher, C. J. and Basson, C. T. (2001). Getting the T-box dose right. Nat. Med.7,1185-1186.","DOI":"10.1038\/nm1101-1185"},{"key":"2021042611551933800_REF15","doi-asserted-by":"crossref","unstructured":"He, M., Wen, L., Campbell, C. E., Wu, J. Y. and Rao, Y.(1999). Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. USA96,10212-10217.","DOI":"10.1073\/pnas.96.18.10212"},{"key":"2021042611551933800_REF16","doi-asserted-by":"crossref","unstructured":"Hukriede, N. A., Joly, L., Tsang, M., Miles, J., Tellis, P.,Epstein, J. A., Barbazuk, W. B., Li, F. N., Paw, B., Postlethwait, J. H. et al. (1999). Radiation hybrid mapping of the zebrafish genome. Proc. Natl. Acad. Sci. USA96,9745-9750.","DOI":"10.1073\/pnas.96.17.9745"},{"key":"2021042611551933800_REF17","doi-asserted-by":"crossref","unstructured":"Isogai, S., Horiguchi, M. and Weinstein, B. M.(2001). The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Dev. Biol.230,278-301.","DOI":"10.1006\/dbio.2000.9995"},{"key":"2021042611551933800_REF18","doi-asserted-by":"crossref","unstructured":"Jerome, L. A. and Papaioannou, V. E. (2001). DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet.27,286-291.","DOI":"10.1038\/85845"},{"key":"2021042611551933800_REF19","doi-asserted-by":"crossref","unstructured":"Kispert, A., Koschorz, B. and Herrmann, B. G.(1995). The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J.14,4763-4772.","DOI":"10.1002\/j.1460-2075.1995.tb00158.x"},{"key":"2021042611551933800_REF20","doi-asserted-by":"crossref","unstructured":"Knapik, E. W., Goodman, A., Atkinson, O. S., Roberts, C. T.,Shiozawa, M., Sim, C. U., Weksler-Zangen, S., Trolliet, M. R., Futrell, C.,Innes, B. A. et al. (1996). A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. Development123,451-460.","DOI":"10.1242\/dev.123.1.451"},{"key":"2021042611551933800_REF21","doi-asserted-by":"crossref","unstructured":"Kochilas, L., Merscher-Gomez, S., Lu, M. M., Potluri, V., Liao,J., Kucherlapati, R., Morrow, B. and Epstein, J. A. (2002). The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev. Biol.251,157-166.","DOI":"10.1006\/dbio.2002.0819"},{"key":"2021042611551933800_REF22","doi-asserted-by":"crossref","unstructured":"Kurihara, Y., Kurihara, H., Oda, H., Maemura, K., Nagai, R.,Ishikawa, T. and Yazaki, Y. (1995). Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest.96,293-300.","DOI":"10.1172\/JCI118033"},{"key":"2021042611551933800_REF23","doi-asserted-by":"crossref","unstructured":"Kurihara, Y., Kurihara, H., Suzuki, H., Kodama, T., Maemura, K.,Nagai, R., Oda, H., Kuwaki, T., Cao, W. H., Kamada, N. et al.(1994). Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature368,703-710.","DOI":"10.1038\/368703a0"},{"key":"2021042611551933800_REF24","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A. (2001). Chromosomal microdeletions: dissecting del22q11 syndrome. Nat. Rev. Genet.2,858-868.","DOI":"10.1038\/35098574"},{"key":"2021042611551933800_REF25","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A., Vitelli, F., Su, H., Morishima, M., Huynh, T.,Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H. F., Scambler, P. J. et al. (2001). Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature410,97-101.","DOI":"10.1038\/35065105"},{"key":"2021042611551933800_REF26","doi-asserted-by":"crossref","unstructured":"Luo, R., An, M., Arduini, B. L. and Henion, P. D.(2001). Specific pan-neural crest expression of zebrafish Crestin throughout embryonic development. Dev. Dyn.220,169-174.","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1097>3.0.CO;2-1"},{"key":"2021042611551933800_REF27","doi-asserted-by":"crossref","unstructured":"Merscher, S., Funke, B., Epstein, J. A., Heyer, J., Puech, A.,Lu, M. M., Xavier, R. J., Demay, M. B., Russell, R. G., Factor, S. et al.(2001). TBX1 is responsible for cardiovascular defects in velo-cardio-facial\/DiGeorge syndrome. Cell104,619-629.","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"2021042611551933800_REF28","doi-asserted-by":"crossref","unstructured":"Miller, C. T., Schilling, T. F., Lee, K., Parker, J. and Kimmel,C. B. (2000). sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development127,3815-3828.","DOI":"10.1242\/dev.127.17.3815"},{"key":"2021042611551933800_REF29","unstructured":"Moens, C. B. and Fritz, A. (1999). Techniques in neural development. Methods Cell Biol.59,253-272."},{"key":"2021042611551933800_REF30","doi-asserted-by":"crossref","unstructured":"Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M.,Takeda, H. and Araki, K. (2002). Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nat. Genet.31,195-199.","DOI":"10.1038\/ng899"},{"key":"2021042611551933800_REF31","doi-asserted-by":"crossref","unstructured":"Peyrieras, N., Strahle, U. and Rosa, F. (1998). Conversion of zebrafish blastomeres to an endodermal fate by TGF-beta-related signaling. Curr. Biol.8, 783-786.","DOI":"10.1016\/S0960-9822(98)70303-3"},{"key":"2021042611551933800_REF32","doi-asserted-by":"crossref","unstructured":"Piotrowski, T., Schilling, T. F., Brand, M., Jiang, Y. J.,Heisenberg, C. P., Beuchle, D., Grandel, H., van Eeden, F. J., Furutani-Seiki,M., Granato, M. et al. (1996). Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development123,345-356.","DOI":"10.1242\/dev.123.1.345"},{"key":"2021042611551933800_REF33","doi-asserted-by":"crossref","unstructured":"Piotrowski, T. and Nu\u0308sslein-Volhard, C.(2000). The endoderm plays an important role in patterning the segmented pharyngeal region in zebrafish (Danio rerio). Dev. Biol.225,339-356.","DOI":"10.1006\/dbio.2000.9842"},{"key":"2021042611551933800_REF34","unstructured":"Rauch, G. J., Hammerschmidt, M., Blader, P., Schauerte, H. E.,Strahle, U., Ingham, P. W., McMahon, A. P. and Haffter, P.(1997). Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb. Symp. Quant. Biol.62,227-234."},{"key":"2021042611551933800_REF35","unstructured":"Reifers, F., Bohli, H., Walsh, E. C., Crossley, P. H., Stainier,D. Y. and Brand, M. (1998). Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development125,2381-2395."},{"key":"2021042611551933800_REF36","doi-asserted-by":"crossref","unstructured":"Renucci, A., Lemarchandel, V. and Rosa, F.(1996). An activated form of type I serine\/threonine kinase receptor TARAM-A reveals a specific signalling pathway involved in fish head organiser formation. Development122,3735-3743.","DOI":"10.1242\/dev.122.12.3735"},{"key":"2021042611551933800_REF37","doi-asserted-by":"crossref","unstructured":"Rubinstein, A. L., Lee, D., Luo, R., Henion, P. D. and Halpern,M. E. (2000). Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. Genesis26,86-97.","DOI":"10.1002\/(SICI)1526-968X(200001)26:1<86::AID-GENE11>3.0.CO;2-Q"},{"key":"2021042611551933800_REF38","doi-asserted-by":"crossref","unstructured":"Ryan, A. K., Goodship, J. A., Wilson, D. I., Philip, N., Levy,A., Seidel, H., Schuffenhauer, S., Oechsler, H., Belohradsky, B., Prieur, M. et al. (1997). Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study. J. Med. Genet.34,798-804.","DOI":"10.1136\/jmg.34.10.798"},{"key":"2021042611551933800_REF39","doi-asserted-by":"crossref","unstructured":"Scambler, P. J. (2000). The 22q11 deletion syndromes. Hum. Mol. Genet.9,2421-2426.","DOI":"10.1093\/hmg\/9.16.2421"},{"key":"2021042611551933800_REF40","doi-asserted-by":"crossref","unstructured":"Schilling, T. F., Piotrowski, T., Grandel, H., Brand, M.,Heisenberg, C. P. Jiang, Y. J., Beuchle, D., Hammerschmidt, M., Kane, D. A.,Mullins, M. C. et al. (1996). Jaw and branchial arch mutants in zebrafish I: branchial arches. Development123,329-344.","DOI":"10.1242\/dev.123.1.329"},{"key":"2021042611551933800_REF41","doi-asserted-by":"crossref","unstructured":"Schulte-Merker, S., van Eeden, F. J., Halpern, M. E., Kimmel, C. B. and Nu\u0308sslein-Volhard, C. (1994). no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development120,1009-1015.","DOI":"10.1242\/dev.120.4.1009"},{"key":"2021042611551933800_REF42","doi-asserted-by":"crossref","unstructured":"Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D. and Olson, E. N. (1997). Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat. Genet.16,154-160.","DOI":"10.1038\/ng0697-154"},{"key":"2021042611551933800_REF43","doi-asserted-by":"crossref","unstructured":"Stalmans, I., Lambrechts, D., de Smet, F., Jansen, S., Wang, J.,Maity, S., Kneer, P., von Der Ohe, M., Swillen, A., Maes, C. et al.(2003). VEGF: a modifier of the del22q11 (DiGeorge) syndrome?Nat. Med.9,173-182.","DOI":"10.1038\/nm819"},{"key":"2021042611551933800_REF44","doi-asserted-by":"crossref","unstructured":"Thomas, T., Kurihara, H., Yamagishi, H., Kurihara, Y., Yazaki,Y., Olson, E. N. and Srivastava, D. (1998). A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development125,3005-3014.","DOI":"10.1242\/dev.125.16.3005"},{"key":"2021042611551933800_REF45","doi-asserted-by":"crossref","unstructured":"Trumpp, A., Depew, M. J., Rubenstein, J. L., Bishop, J. M. and Martin, G. R. (1999). Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev.13,3136-3148.","DOI":"10.1101\/gad.13.23.3136"},{"key":"2021042611551933800_REF46","doi-asserted-by":"crossref","unstructured":"Tucker, A. S., Yamada, G., Grigoriou, M., Pachnis, V. and Sharpe, P. T. (1999). Fgf-8 determines rostral-caudal polarity in the first branchial arch. Development126, 51-61.","DOI":"10.1242\/dev.126.1.51"},{"key":"2021042611551933800_REF47","unstructured":"Vitelli, F., Taddei, I., Morishima, M., Meyers, E. N., Lindsay,E. A. and Baldini, A. (2002). A genetic link between Tbx1 and fibroblast growth factor signaling. Development129,4605-4611."},{"key":"2021042611551933800_REF48","doi-asserted-by":"crossref","unstructured":"Weinberg, E. S., Allende, M. L., Kelly, C. S., Abdelhamid, A.,Murakami, T., Andermann, P., Doerre, O. G., Grunwald, D. J. and Riggleman,B. (1996). Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Development122,271-280.","DOI":"10.1242\/dev.122.1.271"},{"key":"2021042611551933800_REF49","doi-asserted-by":"crossref","unstructured":"Weinstein, B. M., Stemple, D. L., Driever, W. and Fishman, M. C. (1995). Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nat. Med.1,1143-1147.","DOI":"10.1038\/nm1195-1143"},{"key":"2021042611551933800_REF50","doi-asserted-by":"crossref","unstructured":"Whitfield, T. T., Granato, M., van Eeden, F. J., Schach, U.,Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C. P., Jiang, Y. J. et al. (1996). Mutations affecting development of the zebrafish inner ear and lateral line. Development123,241-254.","DOI":"10.1242\/dev.123.1.241"},{"key":"2021042611551933800_REF51","doi-asserted-by":"crossref","unstructured":"Yamagishi, H., Maeda, J., Hu, T., McAnally, J., Conway, S. J.,Kume, T., Meyers, E. N., Yamagishi, C. and Srivastava, D.(2003). Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev.17,269-281.","DOI":"10.1101\/gad.1048903"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/130\/20\/5043\/1144852\/5043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/130\/20\/5043\/1144852\/5043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T11:29:31Z","timestamp":1734089371000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/130\/20\/5043\/52249\/The-zebrafish-van-gogh-mutation-disrupts-tbx1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,15]]},"references-count":51,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2003,10,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.00704","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1015274.196173","asserted-by":"object"}]},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10,15]]}}}