{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:08:09Z","timestamp":1781204889405,"version":"3.54.1"},"reference-count":40,"publisher":"The Company of Biologists","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>The Hox gene lin-39 plays a crucial role in the establishment of the nematode vulva equivalence group. Mutations in lin-39 in Caenorhabditis elegans and Pristionchus pacificus result in a vulvaless phenotype because presumptive vulva precursor cells adopt non-vulval fates. Interestingly, the non-vulval fate of anterior and posterior epidermal cells differs between Caenorhabditis and Pristionchus; in C. elegans, non-vulval cells fuse with the hypodermis, whereas, in P. pacificus, they die as a result of programmed cell death. C. elegans lin-39 (Cel-lin-39)indirectly controls the cell fusion gene eff-1 by regulating the GATA transcription factors egl-18 and elt-6. In P. pacificus, the genetic context of its lin-39(Ppa-lin-39) function was unknown. Here, we describe the isolation and characterization of gev-2, a second generation-vulvaless mutant in P. pacificus. We show that gev-2 is the Ppa-pax-3 gene and that it has distinct functions in the cell fate specification of epidermal cells. Whereas Ppa-pax-3 regulates cell survival of the presumptive vulval precursor cells, it controls cell death of posterior epidermal cells. Molecular studies indicate that Ppa-pax-3is a direct target of Ppa-LIN-39. Thus, we describe the first specific developmental defect of a nematode pax-3 gene and our data reveal different regulatory networks for the specification of the vulva equivalence group.<\/jats:p>","DOI":"10.1242\/dev.008375","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T00:51:54Z","timestamp":1185411114000},"page":"3111-3119","source":"Crossref","is-referenced-by-count":13,"title":["The<i>pax-3<\/i>gene is involved in vulva formation in<i>Pristionchus pacificus<\/i>and is a target of the Hox gene<i>lin-39<\/i>"],"prefix":"10.1242","volume":"134","author":[{"given":"Buqing","family":"Yi","sequence":"first","affiliation":[{"name":"Max-Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D-72076 Tu\u0308bingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Developmental Biology, Department for Evolutionary Biology, Spemannstrasse 37, D-72076 Tu\u0308bingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042621014355600_REF1","unstructured":"Alper, S. and Kenyon, C. 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(1998). The Pristionchus pacificus mab-5 gene is involved in the regulation of ventral epidermal cell fates. Curr. Biol.8, 775-778.","DOI":"10.1016\/S0960-9822(98)70301-X"},{"key":"2021042621014355600_REF16","doi-asserted-by":"crossref","unstructured":"Jungblut, B. and Sommer, R. J. (2000). Novel cell-cell interactions during vulva development in Pristionchus pacificus.Development127,3295-3303.","DOI":"10.1242\/dev.127.15.3295"},{"key":"2021042621014355600_REF17","doi-asserted-by":"crossref","unstructured":"Jungblut, B. and Sommer, R. J. (2001). The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus.Development128,253-261.","DOI":"10.1242\/dev.128.2.253"},{"key":"2021042621014355600_REF18","doi-asserted-by":"crossref","unstructured":"Kenning, C., Kipping, I. and Sommer, R. J.(2004). 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Genet.37,300-304.","DOI":"10.1038\/ng1512"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/134\/17\/3111\/1549164\/3111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/134\/17\/3111\/1549164\/3111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T01:50:52Z","timestamp":1708134652000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/134\/17\/3111\/64493\/The-pax-3-gene-is-involved-in-vulva-formation-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,1]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.008375","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9,1]]}}}