{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:14:46Z","timestamp":1792077286834,"version":"4.4.0"},"reference-count":50,"publisher":"The Company of Biologists","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,29]]},"abstract":"<jats:p>We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose), while their central target, the nucleus of the solitary tract,which integrates all visceral information, never forms. These data establish Phox2b as an unusual `circuit-specific' transcription factor devoted to the formation of autonomic reflex pathways. We also show that Phox2b heterozygous mutants have an altered response to hypoxia and hypercapnia at birth and a decreased tyrosine hydroxylase expression in the petrosal chemosensory neurons, thus providing mechanistic insight into congenital central hypoventilation syndrome, which is associated with heterozygous mutations in PHOX2B.<\/jats:p>","DOI":"10.1242\/dev.00866","type":"journal-article","created":{"date-parts":[[2003,11,25]],"date-time":"2003-11-25T01:12:55Z","timestamp":1069722775000},"page":"6635-6642","source":"Crossref","is-referenced-by-count":315,"title":["<i>Phox2b<\/i>controls the development of peripheral chemoreceptors and afferent visceral pathways"],"prefix":"10.1242","volume":"130","author":[{"given":"Ste\u0301phane","family":"Dauger","sequence":"first","affiliation":[{"name":"Laboratoire de Neurologie et Physiologie du De\u0301veloppement, INSERM EPI9935, Ho\u0302pital Robert Debre\u0301, 48 Bd Serurier, 75019 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Pattyn","sequence":"additional","affiliation":[{"name":"CNRS UMR 8542, De\u0301partement de Biologie, Ecole Normale Supe\u0301rieure, 46 rue d'Ulm, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Lofaso","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurologie et Physiologie du De\u0301veloppement, INSERM EPI9935, Ho\u0302pital Robert Debre\u0301, 48 Bd Serurier, 75019 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gaultier","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurologie et Physiologie du De\u0301veloppement, INSERM EPI9935, Ho\u0302pital Robert Debre\u0301, 48 Bd Serurier, 75019 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christo","family":"Goridis","sequence":"additional","affiliation":[{"name":"CNRS UMR 8542, De\u0301partement de Biologie, Ecole Normale Supe\u0301rieure, 46 rue d'Ulm, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gallego","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurologie et Physiologie du De\u0301veloppement, INSERM EPI9935, Ho\u0302pital Robert Debre\u0301, 48 Bd Serurier, 75019 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Franc\u0327ois","family":"Brunet","sequence":"additional","affiliation":[{"name":"CNRS UMR 8542, De\u0301partement de Biologie, Ecole Normale Supe\u0301rieure, 46 rue d'Ulm, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042611533197200_REF1","doi-asserted-by":"crossref","unstructured":"Amiel, J., Laudier, B., Attie\u0301-Bitach, T., Trang, H., de Pontual, L., Gener, B., Torchet, D., Simonneau, M., Vekemans, M., Munnich, A. et al. 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