{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:38:18Z","timestamp":1778571498172,"version":"3.51.4"},"reference-count":61,"publisher":"The Company of Biologists","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>We identified a zebrafish caudal-related homeobox (cdx1b)gene, which shares syntenic conservation with both human and mouse Cdx1. Zebrafish cdx1b transcripts are maternally deposited. cdx1b is uniformly expressed in both epiblast and hypoblast cells from late gastrulation to the 1-2s stages and can be identified in the retinas, brain and somites during 18-22 hpf stages. After 28 hours of development, cdx1b is exclusively expressed in the developing intestine. Both antisense morpholino oligonucleotide-mediated knockdown and overexpression experiments were conducted to analyze cdx1b function. Hypoplastic development of the liver and pancreas and intestinal abnormalities were observed in 96 hpf cdx1b morphants. In 85% epiboly cdx1b morphants, twofold decreases in the respective numbers of gata5-, cas-, foxa2- and sox17-expressing endodermal precursors were identified. Furthermore, ectopic cdx1bexpression caused substantial increases in the respective numbers of gata5-, cas-, foxa2- and sox17-expressing endodermal precursors and altered their distribution patterns in 85% epiboly injected embryos. Conserved Cdx1-binding motifs were identified in both gata5 and foxa2 genes by interspecific sequence comparisons. Cdx1b can bind to the Cdx1-binding motif located in intron 1 of the foxa2 gene based on an electrophoretic mobility shift assay. Co-injection of either zebrafish or mouse foxa2 mRNA with the cdx1b MO rescued the expression domains of ceruloplasmin in the liver of 53 hpf injected embryos. These results indicate that zebrafish cdx1b regulates foxa2 expression and may also modulate gata5 expression, thus affecting early endoderm formation. This study underscores a novel role of zebrafish cdx1b in the development of different digestive organs compared with its mammalian homologs.<\/jats:p>","DOI":"10.1242\/dev.010595","type":"journal-article","created":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T01:35:24Z","timestamp":1201743324000},"page":"941-952","source":"Crossref","is-referenced-by-count":28,"title":["Zebrafish<i>cdx1b<\/i>regulates expression of downstream factors of Nodal signaling during early endoderm formation"],"prefix":"10.1242","volume":"135","author":[{"given":"Pei-Yi","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University,Keelung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology (formerly Institute of Zoology),Academia Sinica, Nankang, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Shiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology (formerly Institute of Zoology),Academia Sinica, Nankang, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fen","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology (formerly Institute of Zoology),Academia Sinica, Nankang, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University,Keelung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Ching","family":"Chung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biology, National Taiwan Ocean University, Keelung,Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Ying","family":"Chu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biochemical Sciences, National Taiwan University,Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jen","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biochemical Sciences, National Taiwan University,Taipei, Taiwan."},{"name":"Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei,Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University,Keelung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Korzh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National University of Singapore, Singapore 11754, Republic of Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Leih","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Organismic Biology (formerly Institute of Zoology),Academia Sinica, Nankang, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ping L.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University,Keelung, Taiwan."},{"name":"Institute of Cellular and Organismic Biology (formerly Institute of Zoology),Academia Sinica, Nankang, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042621261710900_REF1","doi-asserted-by":"crossref","unstructured":"Alexander, J. and Stainier, D. Y. R. (1999). A molecular pathway leading to endoderm formation in zebrafish. Curr. Biol. 9,1147-1157.","DOI":"10.1016\/S0960-9822(00)80016-0"},{"key":"2021042621261710900_REF2","doi-asserted-by":"crossref","unstructured":"Alexander, J., Rothenberg, M., Henry, G. L. and Stainier, D. Y. R. (1999). Casanova plays an early and essential role in endoderm formation in zebrafish. Dev. Biol. 215,343-357.","DOI":"10.1006\/dbio.1999.9441"},{"key":"2021042621261710900_REF3","doi-asserted-by":"crossref","unstructured":"Aoki, T. O., Mathieu, J., Saint-Etienne, L., Rebagliati, M. R.,Peyrieras, N. and Rosa, F. M. (2002). Regulation of nodal signaling and mesendoderm formation by TARAM-a, a TGF\u03b2-related type I receptor. Dev. Biol. 241,273-288.","DOI":"10.1006\/dbio.2001.0510"},{"key":"2021042621261710900_REF4","doi-asserted-by":"crossref","unstructured":"Beck, F. (2004). The role of Cdx genes in the mammalian gut. Gut53,1394-1396.","DOI":"10.1136\/gut.2003.038240"},{"key":"2021042621261710900_REF5","doi-asserted-by":"crossref","unstructured":"Beck, F., Chawengsaksophak, K., Luckett, J., Giblett, S., Tucci,J., Brown, J., Poulsom, R., Jeffery, R. and Wright, N. A.(2003). A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice. Dev. Biol. 255,399-406.","DOI":"10.1016\/S0012-1606(02)00096-9"},{"key":"2021042621261710900_REF6","doi-asserted-by":"crossref","unstructured":"Bjornson, C. R. R., Griffin, K. J. P., Farr, G. H., III,Terashima, A., Himeda, C., Kikuchi, Y. and Kimelman, D.(2005). Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish. Development9, 523-533.","DOI":"10.1016\/j.devcel.2005.08.010"},{"key":"2021042621261710900_REF7","doi-asserted-by":"crossref","unstructured":"Bossard, P. and Zaret, K. S. (1998). GATA transcription factors as potentiators of gut endoderm differentiation. Development125,4909-4917.","DOI":"10.1242\/dev.125.24.4909"},{"key":"2021042621261710900_REF8","doi-asserted-by":"crossref","unstructured":"Brown, C. T., Xie, Y., Davidson, E. H. and Cameron, R. A.(2005). Paircomp, FamilyRelationsII and Cartwheel: tools for interspecific sequence comparison. BMC Bioinformatics6, 70-77.","DOI":"10.1186\/1471-2105-6-70"},{"key":"2021042621261710900_REF9","doi-asserted-by":"crossref","unstructured":"Chawengsaksophak, K., James, R., Hammond, V. E., Kontgen, F. and Beck, F. (1997). Homeosis and intestinal tumours in Cdx2 mutant mice. Nature386, 84-87.","DOI":"10.1038\/386084a0"},{"key":"2021042621261710900_REF10","doi-asserted-by":"crossref","unstructured":"Cockell, M., Stolarczyk, D., Frutiger, S., Hughes, G.,Hagenbuchle, O. and Wellauer, P. K. (1995). Binding sites for hepatocyte nuclear factor 3\u03b2 or 3\u03b3 and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic\u03b1-amylase. Mol. Cell. Biol. 15,1933-1941.","DOI":"10.1128\/MCB.15.4.1933"},{"key":"2021042621261710900_REF11","doi-asserted-by":"crossref","unstructured":"Davidson, A. J. and Zon, L. I. (2006). The caudal-related homeobox gene cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev. Biol. 292,506-518.","DOI":"10.1016\/j.ydbio.2006.01.003"},{"key":"2021042621261710900_REF12","doi-asserted-by":"crossref","unstructured":"Davidson, A. J., Ernst, P., Wang, Y., Dekens, M. P. S.,Kingsley, P. D., Palis, J., Korsmeyer, S. J., Daley, G. Q. and Zon, L. I.(2003). cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature425,300-306.","DOI":"10.1038\/nature01973"},{"key":"2021042621261710900_REF13","unstructured":"Deryckere, F. and Gannon, F. (1994). A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. BioTechniques16, 405."},{"key":"2021042621261710900_REF14","doi-asserted-by":"crossref","unstructured":"de Santa Barbara, P., van den Brink, G. R. and Roberts, D. J. (2003). Development and differentiation of the intestinal epithelium. Cell. Mol. Life Sci. 60,1322-1332.","DOI":"10.1007\/s00018-003-2289-3"},{"key":"2021042621261710900_REF15","doi-asserted-by":"crossref","unstructured":"Dufort, D., Schwartz, L., Harpal, K. and Rossant, J.(1998). The transcription factor hnf3\u03b2 is required in visceral endoderm for normal primitive streak morphogenesis. Development125,3015-3025.","DOI":"10.1242\/dev.125.16.3015"},{"key":"2021042621261710900_REF16","doi-asserted-by":"crossref","unstructured":"Duncan, S. A., Navas, A., Dufort, D., Rossant, J. and Stoffel,M. (1998). Regulation of a transcription factor network required for differentiation and metabolism. Science281,692-695.","DOI":"10.1126\/science.281.5377.692"},{"key":"2021042621261710900_REF17","doi-asserted-by":"crossref","unstructured":"Edlund, H. (2002). Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat. Rev. Genet. 3,524-532.","DOI":"10.1038\/nrg841"},{"key":"2021042621261710900_REF18","doi-asserted-by":"crossref","unstructured":"Feldman, B., Gates, M. A., Egan, E. S., Dougan, S. T.,Rennebeck, G., Sirotkin, H. I., Schier, A. F. and Talbot, W. S.(1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature395,181-185.","DOI":"10.1038\/26013"},{"key":"2021042621261710900_REF19","unstructured":"Felsenstein, J. (2000). PHYLIP 3.6: Phylogeny Inference Package, http:\/\/evolution.genetics.washington.edu\/phylip\/."},{"key":"2021042621261710900_REF20","doi-asserted-by":"crossref","unstructured":"Field, H. A., Ober, E. A., Roeser, T. and Stainier, D. Y. R.(2003a). Formation of the digestive system in zebrafish. 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Zebrafish pou5f1\/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr. Biol. 14,48-55.","DOI":"10.1016\/j.cub.2003.11.022"},{"key":"2021042621261710900_REF41","doi-asserted-by":"crossref","unstructured":"Matsumoto, K., Yoshitomi, H., Rossant, J. and Zaret, K. S.(2001). Liver organogenesis promoted by endothelial cells prior to vascular function. Science294,559-563.","DOI":"10.1126\/science.1063889"},{"key":"2021042621261710900_REF42","doi-asserted-by":"crossref","unstructured":"Meyer, B. I. and Gruss, P. (1993). Mouse cdx-1 expression during gastrulation. Development117,191-203.","DOI":"10.1242\/dev.117.1.191"},{"key":"2021042621261710900_REF43","doi-asserted-by":"crossref","unstructured":"Murtaugh, L. C., Stanger, B. Z., Kwan, K. M. and Melton, D. A. (2003). Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl. Acad. Sci. 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L., Kanai-Azuma, M. and Kanai, Y.(2003). Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr. Opin. Genet. Dev. 13,393-400.","DOI":"10.1016\/S0959-437X(03)00085-6"},{"key":"2021042621261710900_REF58","doi-asserted-by":"crossref","unstructured":"Wallace, K. N. and Pack, M. (2003). Unique and conserved aspects of gut development in zebrafish. Dev. Biol. 255,12-29.","DOI":"10.1016\/S0012-1606(02)00034-9"},{"key":"2021042621261710900_REF59","doi-asserted-by":"crossref","unstructured":"Wells, J. M. and Melton, D. A. (1999). Vertebrate endoderm development. Annu. Rev. Cell Dev. Biol. 15,393-410.","DOI":"10.1146\/annurev.cellbio.15.1.393"},{"key":"2021042621261710900_REF60","unstructured":"Westerfield, M. (1995). The Zebrafish Book (3rd edn). Eugene, OR: University of Oregon Press."},{"key":"2021042621261710900_REF61","doi-asserted-by":"crossref","unstructured":"Yee, N. S., Yusuff, S. and Pack, M. (2001). 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