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However, in marked contrast to the embryonic lethality of Pdgfb null mutants, the endothelium-specific mutants survived into adulthood with persistent pathological changes,including brain microhemorrhages, focal astrogliosis, and kidney glomerulus abnormalities. This spectrum of pathological changes is reminiscent of diabetic microangiopathy, suggesting that the endothelium-restricted Pdgfb knockouts may serve as models for some of the pathogenic events of vascular complications to diabetes.<\/jats:p>","DOI":"10.1242\/dev.01080","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T22:33:04Z","timestamp":1080685984000},"page":"1847-1857","source":"Crossref","is-referenced-by-count":328,"title":["Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities"],"prefix":"10.1242","volume":"131","author":[{"given":"Mattias","family":"Bjarnega\u030ard","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Enge","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Norlin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Gustafsdottir","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala,Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fredriksson","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala,Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Abramsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology, Lund University, SE 221 85 Lund,Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Fa\u0308ssler","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Biochemistry, Department of Molecular Medicine, Am Klopferspitz 18a, D-82152 Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Betsholtz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Go\u0308teborg University, PO Box 440, SE 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604485173700_REF1","doi-asserted-by":"crossref","unstructured":"Abramsson, A., Berlin, O\u0308., Papayan, H., Paulin, D., Shani,M. and Betsholtz, C. 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