{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:15:23Z","timestamp":1784877323382,"version":"3.55.0"},"reference-count":64,"publisher":"The Company of Biologists","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:p>The pituitary gland consists of two major parts: the neurohypophysis, which is of neural origin; and the adenohypophysis, which is of non-neural ectodermal origin. Development of the adenohypophysis is governed by signaling proteins from the infundibulum, a ventral structure of the diencephalon that gives rise to the neurohypophysis. In mouse, the fibroblast growth factors Fgf8, Fgf10 and Fgf18 are thought to affect multiple processes of pituitary development: morphogenesis and patterning of the adenohypophyseal anlage; and survival, proliferation and differential specification of adenohypophyseal progenitor cells. Here, we investigate the role of Fgf3 during pituitary development in the zebrafish, analyzing lia\/fgf3 null mutants. We show that Fgf3 signaling from the ventral diencephalon is required in a non-cell autonomous fashion to induce the expression of lim3,pit1 and other pituitary-specific genes in the underlying adenohypophyseal progenitor cells. Despite the absence of such early specification steps, fgf3 mutants continue to form a distinct pituitary anlage of normal size and shape, until adenohypophyseal cells die by apoptosis. We further show that Sonic Hedgehog (Shh) cannot rescue pituitary development, although it is able to induce adenohypophyseal cells in ectopic placodal regions of fgf3 mutants, indicating that Fgf3 does not act via Shh, and that Shh can act independently of Fgf3. In sum, our data suggest that Fgf3 signaling primarily promotes the transcriptional activation of genes regulating early specification steps of adenohypophyseal progenitor cells. This early specification seems to be essential for the subsequent survival of pituitary cells, but not for pituitary morphogenesis or pituitary cell proliferation.<\/jats:p>","DOI":"10.1242\/dev.01235","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T01:47:15Z","timestamp":1088646435000},"page":"3681-3692","source":"Crossref","is-referenced-by-count":116,"title":["Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis"],"prefix":"10.1242","volume":"131","author":[{"given":"Wiebke","family":"Herzog","sequence":"first","affiliation":[{"name":"Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Sonntag","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"von der Hardt","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Roehl","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Developmental Biology, Spemannstra\u00dfe 35, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan M.","family":"Varga","sequence":"additional","affiliation":[{"name":"University of Freiburg, Department of Biology I, Hauptstra\u00dfe 1, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hammerschmidt","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605073569100_REF1","doi-asserted-by":"crossref","unstructured":"Akimenko, M.-A., Ekker, M., Wegner, J., Lin, W. and Westerfield,M. (1994). Combinatorial expression of three zebrafish genes related to distalless: part of a homeobox gene code for the head. J. Neurosci.16,3475-3486.","DOI":"10.1523\/JNEUROSCI.14-06-03475.1994"},{"key":"2021042605073569100_REF2","unstructured":"Anderson, B. and Rosenfeld, M. G. (2001). POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocrinol. Rev.22,2-35."},{"key":"2021042605073569100_REF3","doi-asserted-by":"crossref","unstructured":"Baker, C. V. H. and Bronner-Fraser, M. (2001). Vertebrate cranial placodes I: embryonic induction. Dev. Biol.232,1-61.","DOI":"10.1006\/dbio.2001.0156"},{"key":"2021042605073569100_REF4","doi-asserted-by":"crossref","unstructured":"Burgess, R., Lunyak, V. and Rosenfeld, M. G.(2002). Signaling and transcriptional control of pituitary development. Curr. Opin. Genet. Dev.12,534-539.","DOI":"10.1016\/S0959-437X(02)00337-4"},{"key":"2021042605073569100_REF5","doi-asserted-by":"crossref","unstructured":"David, N. B., Saint-Etienne, L., Tsang, M., Schilling, T. F. and Rosa, F. M. (2002). Requirement for endoderm and FGF3 in ventral skeleton formation. Development129,4457-4468.","DOI":"10.1242\/dev.129.19.4457"},{"key":"2021042605073569100_REF6","unstructured":"De Moerlooze, L., Spencer-Dene, B., Revest, J.-M., Hajihosseini,M., Rosewell, I. and Dickson, C. (2000). An important role for the IIIb isoform of fibroblast growth factor 2 (FGFR2) in mesenchymal-epithelial signaling during mouse organogenesis. Development127,483-492."},{"key":"2021042605073569100_REF7","doi-asserted-by":"crossref","unstructured":"Ericson, J., Norlin, S., Jessell, T. M. and Edlund, T.(1998). Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development125,1005-1015.","DOI":"10.1242\/dev.125.6.1005"},{"key":"2021042605073569100_REF8","doi-asserted-by":"crossref","unstructured":"Fischer, S., Draper, B. W. and Neumann, C. J.(2003). The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Development130,3515-3524.","DOI":"10.1242\/dev.00537"},{"key":"2021042605073569100_REF9","unstructured":"Fu\u0308rthauer, M., Reifers, F., Brand, M., Thisse, B. and Thisse, C. (2001). sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development128,2175-2186."},{"key":"2021042605073569100_REF10","doi-asserted-by":"crossref","unstructured":"Fu\u0308rthauer, M., Thisse, C. and Thisse, B.(1997). A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development124,4253-4264.","DOI":"10.1242\/dev.124.21.4253"},{"key":"2021042605073569100_REF11","doi-asserted-by":"crossref","unstructured":"Geisler, R. (2002). Mapping and cloning. In Zebrafish, Practical approach, vol.261 (ed. C. Nu\u0308sslein-Volhard and R. Dahm), pp.175-212. Oxford, UK: Oxford University Press.","DOI":"10.1093\/oso\/9780199638086.003.0008"},{"key":"2021042605073569100_REF12","doi-asserted-by":"crossref","unstructured":"Glasgow, E., Karavanov, A. A. and Dawid, I. B.(1997). Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Dev. Biol.192,405-419.","DOI":"10.1006\/dbio.1997.8761"},{"key":"2021042605073569100_REF13","doi-asserted-by":"crossref","unstructured":"Hammerschmidt, M., Pelegri, F., Mullins, M. C., Kane, D. A., van Eeden, F. J. M., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P.,Heisenberg, C.-P. et al. (1996). dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development123,95-102.","DOI":"10.1242\/dev.123.1.95"},{"key":"2021042605073569100_REF14","doi-asserted-by":"crossref","unstructured":"Heisenberg, C.-P., Brennan, C. and Wilson, S. W.(1999). Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development. Development126,2129-2140.","DOI":"10.1242\/dev.126.10.2129"},{"key":"2021042605073569100_REF15","doi-asserted-by":"crossref","unstructured":"Herzog, W., Sonntag, C., Walderich, B., Odenthal, J., Maischein,H.-M. and Hammerschmidt, M. (2004). Genetic analysis of adenohypophysis formation in zebrafish. Mol. Endocrinol.18,1185-1195.","DOI":"10.1210\/me.2003-0376"},{"key":"2021042605073569100_REF16","doi-asserted-by":"crossref","unstructured":"Herzog, W., Zeng, X., Lele, Z., Sonntag, C., Ting, J.-W., Chang,C.-Y. and Hammerschmidt, M. (2003). Adenohypophysis formation in the zebrafish and its dependence on Sonic Hedgehog. Dev. 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Biol.244,9-20.","DOI":"10.1006\/dbio.2002.0581"},{"key":"2021042605073569100_REF20","doi-asserted-by":"crossref","unstructured":"Krauss, S., Concordet, J.-P. and Ingham, P. W.(1993). A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell75,1431-1444.","DOI":"10.1016\/0092-8674(93)90628-4"},{"key":"2021042605073569100_REF21","doi-asserted-by":"crossref","unstructured":"Lamolet, B., Pulichino, A.-M., Lamonerie, T., Gauthier, Y.,Brue, T., Enjalbert, A. and Drouin, J. (2001). A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell104,849-859.","DOI":"10.1016\/S0092-8674(01)00282-3"},{"key":"2021042605073569100_REF22","doi-asserted-by":"crossref","unstructured":"Leger, S. and Brand, M. (2002). Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning. Mech. 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Cloning of the zebrafish Krox-20 (Krx-20) and its expression during hindbrain development. Nucleic Acids Res.21,1087-1095.","DOI":"10.1093\/nar\/21.5.1087"},{"key":"2021042605073569100_REF41","doi-asserted-by":"crossref","unstructured":"Phillips, B. T., Bolding, K. and Riley, B. B.(2001). Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction. Dev. Biol.235,351-365.","DOI":"10.1006\/dbio.2001.0297"},{"key":"2021042605073569100_REF42","doi-asserted-by":"crossref","unstructured":"Powers, C. J., McLeskey, S. W. and Wellstein, A.(2000). Fibroblast growth factors, their receptors and signaling. Endocr. Relat. Cancer7,165-197.","DOI":"10.1677\/erc.0.0070165"},{"key":"2021042605073569100_REF43","unstructured":"Reifers, F., Bo\u0308hli, H., Walsh, E. C., Crossley, P. H.,Stanier, D. Y. R. and Brand, M. (1998). Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. 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