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During late embryonic and larval development, the Sra-1 protein is found in the neuropile. Outgrowing photoreceptor neurons express high levels of Sra-1 also in growth cones. Expression of double stranded sra-1 RNA in photoreceptor neurons leads to a stalling of axonal growth. Following knockdown of sra-1function in motoneurons, we noted abnormal neuromuscular junctions similar to what we determined for hypomorphic kette mutations. Similar mutant phenotypes were induced after expression of membrane-bound Sra-1 that lacks the Kette-binding domain, suggesting that sra-1 function is mediated through kette. Furthermore, we could show that both proteins stabilize each other and directly control the regulation of the F-actin cytoskeleton in a Wasp-dependent manner.<\/jats:p>","DOI":"10.1242\/dev.01274","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T02:31:28Z","timestamp":1090463488000},"page":"3981-3989","source":"Crossref","is-referenced-by-count":47,"title":["Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in<i>Drosophila<\/i>"],"prefix":"10.1242","volume":"131","author":[{"given":"Sven","family":"Bogdan","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster,Badestrasse 9, Mu\u0308nster, 48149, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Grewe","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster,Badestrasse 9, Mu\u0308nster, 48149, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Strunk","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster,Badestrasse 9, Mu\u0308nster, 48149, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Mertens","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster,Badestrasse 9, Mu\u0308nster, 48149, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kla\u0308mbt","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Neurobiologie, Universita\u0308t Mu\u0308nster,Badestrasse 9, Mu\u0308nster, 48149, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605073758100_REF1","doi-asserted-by":"crossref","unstructured":"Blagg, S. 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