{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:00:00Z","timestamp":1791979200267,"version":"4.4.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:p>The F-spondin family of extracellular matrix proteins has been implicated in axon outgrowth, fasciculation and neuronal cell migration, as well as in the differentiation and proliferation of non-neuronal cells. In screens for mutants defective in C. elegans embryonic morphogenesis, we identified SPON-1, the only C. elegans member of the spondin family. SPON-1 is synthesized in body muscles and localizes to integrin-containing structures on body muscles and to other basement membranes. SPON-1 maintains strong attachments of muscles to epidermis; in the absence of SPON-1, muscles progressively detach from the epidermis, causing defective epidermal elongation. In animals with reduced integrin function, SPON-1 becomes dose dependent, suggesting that SPON-1 and integrins function in concert to promote the attachment of muscles to the basement membrane. Although spon-1mutants display largely normal neurite outgrowth, spon-1 synergizes with outgrowth defective mutants, revealing a cryptic role for SPON-1 in axon extension. In motoneurons, SPON-1 acts in axon guidance and fasciculation,whereas in interneurons SPON-1 maintains process position. Our results show that a spondin maintains cell-matrix adhesion in multiple tissues.<\/jats:p>","DOI":"10.1242\/dev.015289","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T20:25:34Z","timestamp":1215635134000},"page":"2747-2756","source":"Crossref","is-referenced-by-count":43,"title":["The\n                    <i>C. elegans<\/i>\n                    F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues"],"prefix":"10.1242","volume":"135","author":[{"given":"Wei-Meng","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA."},{"name":"Division of Biological Sciences, University of California San Diego, La Jolla,CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryann E.","family":"Swale","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Goncharov","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California San Diego, La Jolla,CA 92093, USA."},{"name":"Howard Hughes Medical Institute, University of California San Diego, La Jolla,CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of California San Diego, La Jolla,CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605481680600_REF1","doi-asserted-by":"crossref","unstructured":"Ackley, B. 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