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We show that ablating \u03b1v expression in the vascular endothelium has no detectable effect on cerebral blood vessel development, whereas deletion of \u03b1v expression in central nervous system glial cells leads to embryonic and neonatal cerebral hemorrhage. Conditional deletion of \u03b1v integrin in both central nervous system glia and neurons also leads to cerebral hemorrhage, but additionally to severe neurological defects. Approximately 30% of these mutants develop seizures and die by 4 weeks of age. The remaining mutants survive for several months, but develop axonal deterioration in the spinal cord and cerebellum,leading to ataxia and loss of hindlimb coordination. Collectively, these data provide evidence that \u03b1v integrins on embryonic central nervous system neural cells, particularly glia, are necessary for proper cerebral blood vessel development, and also reveal a novel function for \u03b1v integrins expressed on axons in the postnatal central nervous system.<\/jats:p>","DOI":"10.1242\/dev.01551","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T01:18:10Z","timestamp":1102036690000},"page":"165-176","source":"Crossref","is-referenced-by-count":212,"title":["Selective ablation of \u03b1v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death"],"prefix":"10.1242","volume":"132","author":[{"given":"Joseph H.","family":"McCarty","sequence":"first","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Lacy-Hulbert","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"},{"name":"Medical Research Council and University of Edinburgh Center for Inflammation Research, Teviot Place, Edinburgh EH8 9AG, UK"},{"name":"Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Charest","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T.","family":"Bronson","sequence":"additional","affiliation":[{"name":"Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Crowley","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Housman","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Savill","sequence":"additional","affiliation":[{"name":"Medical Research Council and University of Edinburgh Center for Inflammation Research, Teviot Place, Edinburgh EH8 9AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Roes","sequence":"additional","affiliation":[{"name":"Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O.","family":"Hynes","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605135781900_REF1","doi-asserted-by":"crossref","unstructured":"Allende, M. 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