{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:59:39Z","timestamp":1791039579843,"version":"4.1.0"},"reference-count":67,"publisher":"The Company of Biologists","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,15]]},"abstract":"<jats:p>Anteroposterior cell migration and patterning in C. elegans are governed by multiple, interacting signaling pathways and transcription factors. In this study, we have investigated the role of ceh-20, the C. elegans ortholog of the HOX co-factor Extradenticle (Exd\/Pbx), and unc-62, the C. elegans ortholog of Homothorax(Hth\/Meis\/Prep), in two processes that are regulated by Hox gene lin-39: cell migration and vulva formation. As in lin-39mutants, the anterior migrations of neuroblasts in the Q lineage are truncated in Hox co-factor mutants. Surprisingly, though, our findings suggested that the roles of ceh-20 and unc-62 are different from that of lin-39; specifically, ceh-20 and unc-62 but not lin-39 are required for the transmembrane protein MIG-13 to promote anterior migration. To our knowledge, ceh-20 and unc-62 are the only genes that have been implicated in the mig-13 pathway. We find that ceh-20 and unc-62 are also required for several steps in vulva development. Surprisingly, ceh-20 and unc-62mutants have phenotypes that are starkly different from those of lin-39 mutants. Thus, in this process, too, ceh-20 and unc-62 are likely to have functions that are independent of lin-39.<\/jats:p>","DOI":"10.1242\/dev.01569","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T21:17:45Z","timestamp":1110057465000},"page":"1413-1428","source":"Crossref","is-referenced-by-count":41,"title":["The roles of two<i>C. elegans<\/i>HOX co-factor orthologs in cell migration and vulva development"],"prefix":"10.1242","volume":"132","author":[{"given":"Lucie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, Mission Bay Genentech Hall, 600 16th Street, Room S312A, San Francisco, CA 94143-2200, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sym","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, Mission Bay Genentech Hall, 600 16th Street, Room S312A, San Francisco, CA 94143-2200, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, Mission Bay Genentech Hall, 600 16th Street, Room S312A, San Francisco, CA 94143-2200, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605363868400_REF1","doi-asserted-by":"crossref","unstructured":"Abu-Shaar, M., Ryoo, H. 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