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During early forebrain development, megalin deficiency leads to an increase in bone morphogenic protein (Bmp) 4 expression and signaling in the rostral dorsal neuroepithelium, and a subsequent loss of sonic hedgehog (Shh)expression in the ventral forebrain. As a consequence of absent SHH activity,ventrally derived oligodendroglial and interneuronal cell populations are lost in the forebrain of megalin\u2013\/\u2013 embryos. Similar defects are seen in models with enhanced signaling through BMPs, central regulators of neural tube patterning. Because megalin mediates endocytic uptake and degradation of BMP4, these findings indicate a role for megalin in neural tube specification, possibly by acting as BMP4 clearance receptor in the neuroepithelium.<\/jats:p>","DOI":"10.1242\/dev.01580","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T23:36:12Z","timestamp":1104276972000},"page":"405-414","source":"Crossref","is-referenced-by-count":154,"title":["LRP2\/megalin is required for patterning of the ventral telencephalon"],"prefix":"10.1242","volume":"132","author":[{"given":"Robert","family":"Spoelgen","sequence":"first","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Hammes","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Anzenberger","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Zechner","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav M.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Jerchow","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Willnow","sequence":"additional","affiliation":[{"name":"Max-Delbrueck-Center for Molecular Medicine, Berlin, 13092, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605151506700_REF1","doi-asserted-by":"crossref","unstructured":"Anderson, R. 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