{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:12:14Z","timestamp":1791137534251,"version":"4.1.0"},"reference-count":37,"publisher":"The Company of Biologists","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:p>Nectins are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules consisting of four members. Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions, including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synaptic junctions in neurons, and Sertoli cell-spermatid junctions in the testis, in cooperation with, or independently of, cadherins. To further explore the function of nectins, we generated nectin 1\u2013\/\u2013 and nectin 3\u2013\/\u2013 mice. Both nectin 1\u2013\/\u2013 and nectin 3\u2013\/\u2013 mice showed a virtually identical ocular phenotype, microphthalmia, accompanied by a separation of the apex-apex contact between the pigment and non-pigment cell layers of the ciliary epithelia. Immunofluorescence and immunoelectron microscopy revealed that nectin 1 and nectin 3, but not nectin 2, localized at the apex-apex junctions between the pigment and non-pigment cell layers of the ciliary epithelia. However, nectin 1\u2013\/\u2013 and nectin 3\u2013\/\u2013 mice showed no impairment of the apicolateral junctions between the pigment epithelia where nectin 1, nectin 2 and nectin 3 localized, or of the apicolateral junctions between the non-pigment epithelia where nectin 2 and nectin 3, but not nectin 1, localized. These results indicate that the heterophilic trans-interaction between nectin 1 and nectin 3 plays a sentinel role in establishing the apex-apex adhesion between the pigment and non-pigment cell layers of the ciliary epithelia that is essential for the morphogenesis of the ciliary body.<\/jats:p>","DOI":"10.1242\/dev.01697","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T01:25:20Z","timestamp":1109208320000},"page":"1525-1537","source":"Crossref","is-referenced-by-count":108,"title":["Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development"],"prefix":"10.1242","volume":"132","author":[{"given":"Maiko","family":"Inagaki","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine\/Faculty of Medicine, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine\/Faculty of Medicine, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"KAN Research Institute, 93 Chudoji-Awatamachi, Shimogyo-ku, Kyoto 600-8815,Japan"},{"name":"Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Tanaka-Okamoto","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Morimoto","sequence":"additional","affiliation":[{"name":"KAN Research Institute, 93 Chudoji-Awatamachi, Shimogyo-ku, Kyoto 600-8815,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"KAN Research Institute, 93 Chudoji-Awatamachi, Shimogyo-ku, Kyoto 600-8815,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"KAN Research Institute, 93 Chudoji-Awatamachi, Shimogyo-ku, Kyoto 600-8815,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine\/Faculty of Medicine, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612111470700_REF1","unstructured":"Amaral, D. 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