{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:31:48Z","timestamp":1790271108468,"version":"4.1.0"},"reference-count":55,"publisher":"The Company of Biologists","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:p>The short stature homeobox gene SHOX is associated with idiopathic short stature in humans, as seen in Turner syndrome and Leri-Weill dyschondrosteosis, while little is known about its close relative SHOX2. We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans. Shox2-\/- mice develop an incomplete cleft that is confined to the anterior region of the palate, an extremely rare type of clefting in humans. The Shox2-\/- palatal shelves initiate, grow and elevate normally, but the anterior region fails to contact and fuse at the midline, owing to altered cell proliferation and apoptosis, leading to incomplete clefting within the presumptive hard palate. Accompanied with these cellular alterations is an ectopic expression of Fgf10 and Fgfr2c in the anterior palatal mesenchyme of the mutants. Tissue recombination and bead implantation experiments revealed that signals from the anterior palatal epithelium are responsible for the restricted mesenchymal Shox2 expression. BMP activity is necessary but not sufficient for the induction of palatal Shox2 expression. Our results demonstrate an intrinsic requirement for Shox2 in palatogenesis, and support the idea that palatogenesis is differentially regulated along the anteroposterior axis. Furthermore, our results demonstrate that fusion of the posterior palate can occur independently of fusion in the anterior palate.<\/jats:p>","DOI":"10.1242\/dev.02013","type":"journal-article","created":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T00:13:10Z","timestamp":1125706390000},"page":"4397-4406","source":"Crossref","is-referenced-by-count":138,"title":["<i>Shox2<\/i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palate"],"prefix":"10.1242","volume":"132","author":[{"given":"Ling","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Alappat","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Fujian Normal University, Fuzhou, Fujian 350007, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanding","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Fujian Normal University, Fuzhou, Fujian 350007, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiPing","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Department of Cell and Molecular Biology,and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA"},{"name":"College of Bioengineering, Fujian Normal University, Fuzhou, Fujian 350007, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605203109900_REF1","doi-asserted-by":"crossref","unstructured":"Alappat, S. R., Zhang, Z., Suzuki, K., Zhang, X., Liu, H.,Jiang, R., Yamada, G. and Chen, Y. P. (2005). The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev. Biol.277,102-113.","DOI":"10.1016\/j.ydbio.2004.09.010"},{"key":"2021042605203109900_REF2","doi-asserted-by":"crossref","unstructured":"Allanson, J. E., Hennekam, R. C. and Ireland, M.(1997). De Lange syndrome: subjective and objective comparison of the classical and mild phenotypes. J. Med. Genet.34,645-650.","DOI":"10.1136\/jmg.34.8.645"},{"key":"2021042605203109900_REF3","doi-asserted-by":"crossref","unstructured":"Aqua, M. S., Rizzu, P., Lindsay, E. A., Shaffer, L. G., Zackai,E. H., Overhauser, J. and Baldini, A. (1995). Duplication 3q syndrome: molecular delineation of the critical region. Am. J. Med. Genet.55,33-37.","DOI":"10.1002\/ajmg.1320550111"},{"key":"2021042605203109900_REF4","doi-asserted-by":"crossref","unstructured":"Baldwin, C. T., Hoth, C. F., Amos, J. A., da-Silva, E. O. and Milunsky, A. (1992). An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature355,637-638.","DOI":"10.1038\/355637a0"},{"key":"2021042605203109900_REF5","doi-asserted-by":"crossref","unstructured":"Barlow, A. J. and Francis-West, P. H. (1997). Ectopic application of BMP-2 and BMP-4 can change patterning of developing chick facial primordia. Development124,391-398.","DOI":"10.1242\/dev.124.2.391"},{"key":"2021042605203109900_REF6","doi-asserted-by":"crossref","unstructured":"Belin, V., Cusin, V., Viot, G., Girlich, D., Toutain, A.,Moncla, A., Vekemans, M., Le Merrer, M., Munnich, A. and Cormier-Daire, V.(1998). SHOX mutations in dyschondrosteosis (Lo\u0300ei-Weill syndrome). Nat. Genet.19, 67-69.","DOI":"10.1038\/ng0198-67"},{"key":"2021042605203109900_REF7","doi-asserted-by":"crossref","unstructured":"Bellusci, S., Henderson, R., Winnier, G., Oikawa, T. and Hogan,B. L. M. (1996). Evidence from normal expression and targeted misexpression that Bone Morphogenetic Protein-4 (Bmp-4)plays a role in mouse embryonic lung morphogenesis. Development122,1693-1702.","DOI":"10.1242\/dev.122.6.1693"},{"key":"2021042605203109900_REF8","doi-asserted-by":"crossref","unstructured":"Blaschke, R. J., Monaghan, A. P., Schiller, S., Schechinger, B.,Rao, E., Padilla-Nash, H., Ried, T. and Rappold, G. A.(1998). SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. Proc. Natl. Acad. Sci. USA95,2406-2411.","DOI":"10.1073\/pnas.95.5.2406"},{"key":"2021042605203109900_REF9","doi-asserted-by":"crossref","unstructured":"Boncinelli, E. (1997). Homeobox genes and disease. Curr. Opin. Genet. Dev.7, 331-337.","DOI":"10.1016\/S0959-437X(97)80146-3"},{"key":"2021042605203109900_REF10","doi-asserted-by":"crossref","unstructured":"Chai, Y., Jiang, X., Ito, Y., Bringas, P., Jr, Han, J., Rowitch,D., Soriana, P., McMahon, A. and Sucov, H. (2000.). Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development127,1671-1679.","DOI":"10.1242\/dev.127.8.1671"},{"key":"2021042605203109900_REF11","unstructured":"Chen, Y. P. and Maas, R. (1998). Signaling loops in the reciprocal epithelial-mesenchymal interactions of mammalian tooth development. In Molecular basis of epithelial appendage morphogenesis (ed. C.-M, Chuong), pp.265-282. Austin, TX: RG Landes."},{"key":"2021042605203109900_REF12","unstructured":"Chen, Y. P., Bei, M., Woo, I., Satokata, I. and Maas, R.(1996). Msx1 controls inductive signaling during mammalian tooth morphogenesis. Development122,3035-3044."},{"key":"2021042605203109900_REF13","doi-asserted-by":"crossref","unstructured":"Clement-Jones, M., Schiller, S., Rao, E., Blaschke, R. J.,Zuniga, A., Zeller, R., Robson, S. C., Binder, G., Glass, I., Strachan, T. et al. (2000). The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome. Hum. Mol. Genet.9,695-702.","DOI":"10.1093\/hmg\/9.5.695"},{"key":"2021042605203109900_REF14","unstructured":"Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati,P., Bisceglia, L., Zelante, L., Nagaraja, R., Procu, S. et al.(2001). The putative forkhead transcription factor FOXL2 is mutated in blepharonphimosis\/ptosis\/epicanthus inversus syndrome. Nat. Genet.27,132-134."},{"key":"2021042605203109900_REF15","doi-asserted-by":"crossref","unstructured":"Cui, X.-M., Shiomi, N., Chen, J., Saito, T., Yamamoto, T., Ito,Y., Bringas, P., Chai, Y. and Shuler, C. F. (2005). Overexpression of Smad2 in Tgf-\u03b23-null mutant mice rescues cleft palate. Dev. Biol.278,193-202.","DOI":"10.1016\/j.ydbio.2004.10.023"},{"key":"2021042605203109900_REF16","unstructured":"De Moerlooze, L., Spencer-Dene, B., Revest, J., Hajihosseni, M.,Rosewell, I. and Dickson, C. (2000). An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signaling during mouse organogenesis. Development127,483-492."},{"key":"2021042605203109900_REF17","doi-asserted-by":"crossref","unstructured":"Ellison, J. W., Wardak, Z., Young, M. F., Robey, P. G.,Laig-Webster, M. and Chiong, W. (1997). PHOG, a candidate gene for involvement in the short stature of Turner syndrome. Hum. Mol. Genet.6,1341-1347.","DOI":"10.1093\/hmg\/6.8.1341"},{"key":"2021042605203109900_REF18","unstructured":"Fara, M. (1971). Congeital defects in the hard palate. Plast. Reconstr. Surg.48, 44-47."},{"key":"2021042605203109900_REF19","doi-asserted-by":"crossref","unstructured":"Ferguson, M. W. J. (1988). Palate development. Development Suppl.103,41-60.","DOI":"10.1242\/dev.103.Supplement.41"},{"key":"2021042605203109900_REF20","doi-asserted-by":"crossref","unstructured":"Ferguson, M. W. J. and Honig, L. S. (1984). Epithelial-mesenchymal interactions during vertebrate palatogenesis. Curr. Top. Dev. Biol.19,138-164.","DOI":"10.1016\/S0070-2153(08)60398-1"},{"key":"2021042605203109900_REF21","unstructured":"Fryns, J. P. (1995). The occurrence of the blepharophimosis, ptosis, epicanthus inversus syndrome and Langer type of mesomelic dwarfism in the same patient. Evidence of the location of Langer type of mesomelic dwarfism at 3q22.3-q23? Clin. Genet.48,111-112."},{"key":"2021042605203109900_REF22","doi-asserted-by":"crossref","unstructured":"Gillis, L. A., McCallum, J., Kaur, M., DeScipio, C., Yaeger, D.,Mariani, A., Kline, A. D., Li, H. H., Devoto, M. and Jackson, L. G.(2004). NIPBL mutational analysis in 120 individuals with Cornelia de Lange sundrome and evaluation of genotype-phenotype correlations. Am. J. Hum. Genet.75,610-623.","DOI":"10.1086\/424698"},{"key":"2021042605203109900_REF23","doi-asserted-by":"crossref","unstructured":"Glaser, T., Walton, D. S. and Maas, R. L.(1992). Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat. Genet.2, 232-239.","DOI":"10.1038\/ng1192-232"},{"key":"2021042605203109900_REF24","unstructured":"Greene, R. M. and Pratt, R. M. (1976). Developmental aspects of secondary palate development. J. Embryol. Exp. Morph.36,225-245."},{"key":"2021042605203109900_REF25","doi-asserted-by":"crossref","unstructured":"Herr, A., Meunier, D., Mu\u0308ller, I., Rump, A., Fundele, R.,Ropers, H. H. and Nuber, U. A. (2003). Expression of mouse Tbx22 support its role in palatogenesis and glossogenesis. Dev. Dyn.226,579-586.","DOI":"10.1002\/dvdy.10260"},{"key":"2021042605203109900_REF26","unstructured":"Ireland, M., English, C., Cross, I., Houlsby, W. T. and Burn,J. (1991). A de novo translocation t(3;17)(q26.3;q23.1) in a child with Cornelia de Lange syndrome. J. Med. Genet.28,639-640."},{"key":"2021042605203109900_REF27","doi-asserted-by":"crossref","unstructured":"Ito, Y., Yeo, J. Y., Chytil, A., Han, J., Bringas, P., Jr,Nakajima, A., Shuler, C., Moses, H. L. and Chai, Y. (2003). Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development130,5269-5280.","DOI":"10.1242\/dev.00708"},{"key":"2021042605203109900_REF28","doi-asserted-by":"crossref","unstructured":"Johnston, M. C. and Bronsky, P. T. (1995). Prenatal craniofacial development: new insights on normal and abnormal mechanisms. Crit. Rev. Oral. Biol. Med.6, 368-422.","DOI":"10.1177\/10454411950060040601"},{"key":"2021042605203109900_REF29","unstructured":"Kaufman, M. H. and Bard, J. B. L. (1999). The Anatomical Basis of Mouse Development. Academic Press, San Diego, CA."},{"key":"2021042605203109900_REF30","doi-asserted-by":"crossref","unstructured":"Krantz, I. D., McCallum, J., DeScipio, C., Kaur, M., Gillis, L. A., Yaeger, D. Jukofsky, L., Wasserman, N., Bottani, A., Morris, C. A. et al. (2004). Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. Nat. Genet.36,631-635.","DOI":"10.1038\/ng1364"},{"key":"2021042605203109900_REF31","doi-asserted-by":"crossref","unstructured":"Lan, Y., Ovitt, C. E., Cho, E.-S., Maltby, K. M., Wang, Q. and Jiang, R. (2004). Odd-skipped related 2 (Osr2)encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development131,3207-3216.","DOI":"10.1242\/dev.01175"},{"key":"2021042605203109900_REF32","doi-asserted-by":"crossref","unstructured":"Lee, S., Crisera, C. A., Erfani, S., Maldonado, T. S., Lee, J. J., Alkasab, S. L. and Longaker, M. T. (2001). Immunolocalization of fibroblast growth factor receptors 1 and 2 in mouse palate. Plast. Reconstr. Surg.107,1776-1784.","DOI":"10.1097\/00006534-200106000-00021"},{"key":"2021042605203109900_REF33","unstructured":"Mitts, T. F., Garrett, W. S. and Hurwitz, D. J.(1981). Cleft of the hard palate with soft palate integrity. Cleft Palate J.18,204-206."},{"key":"2021042605203109900_REF34","doi-asserted-by":"crossref","unstructured":"Peters, H., Neubuser, A., Kratochwil, K. and Balling, R.(1998). Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev.12,2735-2747.","DOI":"10.1101\/gad.12.17.2735"},{"key":"2021042605203109900_REF35","doi-asserted-by":"crossref","unstructured":"Rao, E., Weiss, B., Fukami, M., Rump, A., Niesler, B., Mertz,A., Muroya, K., Binder, G., Kirsch, S., Winkelmann, M. et al.(1997). Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat. Genet.16,54-63.","DOI":"10.1038\/ng0597-54"},{"key":"2021042605203109900_REF36","doi-asserted-by":"crossref","unstructured":"Rice, R., Spencer-Dene, B., Connor, E. C., Gritli-Linde, A.,McMahon, A. P., Dickson, C., Thesleff, I. and Rice, D. P. C.(2004). Disruption of Fgf10\/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest.113,1692-1700.","DOI":"10.1172\/JCI20384"},{"key":"2021042605203109900_REF37","doi-asserted-by":"crossref","unstructured":"Rovescalli, A. C., Asoh, S. and Nirenberg, M.(1996), Cloning and characterization of four murine homeobox genes. Proc. Natl. Acad. Sci. USA93,10691-10696.","DOI":"10.1073\/pnas.93.20.10691"},{"key":"2021042605203109900_REF38","doi-asserted-by":"crossref","unstructured":"Schupbach, P. M. (1983). Experimental induction of an incomplete hard-palate cleft in the rat. Oral Surg. Oral Med. Oral Pathol.55,2-9.","DOI":"10.1016\/0030-4220(83)90296-7"},{"key":"2021042605203109900_REF39","doi-asserted-by":"crossref","unstructured":"Semina, E. V., Reiter, R., Leysens, N. J., Alward, W. L., Small,K. W., Datson, N. A., Siegel-Bartelt, J., Bierke-Nelson, D., Bitoun, P.,Zabel, B. U. et al. (1996). Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat. Genet.14,392-399.","DOI":"10.1038\/ng1296-392"},{"key":"2021042605203109900_REF40","doi-asserted-by":"crossref","unstructured":"Semina, E. V., Reiter, R. S. and Murray, J. C.(1998). A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse. Hum. Mol. Genet.7, 415-422.","DOI":"10.1093\/hmg\/7.3.415"},{"key":"2021042605203109900_REF41","doi-asserted-by":"crossref","unstructured":"Shears, D. J., Vassal, H. J., Goodman, F. R., Palmer, R. W.,Reardon, W., Superti-Furga, A., Scamber, P. J. and Winter, R. M.(1998). Mutation and deletion of the pseudoautosomal gene SHOX cause Lo\u0300ri-Weill dyschondrosteosis. Nat. Genet.19, 70-73.","DOI":"10.1038\/ng0198-70"},{"key":"2021042605203109900_REF42","doi-asserted-by":"crossref","unstructured":"Shprintzen, R. J. (2002). Terminology and classification of facial clefting. In Understanding Craniofacial Anomalities: The Etiopathogenesis of Craniosynostoses and Facial Clefting (ed. M. P. Mooney and M. I. Siegel), pp.17-28.New York: Wiley-Liss.","DOI":"10.1002\/0471221953.ch3"},{"key":"2021042605203109900_REF43","doi-asserted-by":"crossref","unstructured":"Slavkin, H. C. (1984). Morphogenesis of a complex organ: vertebrate palate development. Curr. Top. Dev. Biol.19,1-16.","DOI":"10.1016\/S0070-2153(08)60392-0"},{"key":"2021042605203109900_REF44","doi-asserted-by":"crossref","unstructured":"Small, K. W., Stalvey, M., Fisher, L., Mullen, L., Dickel, C.,Beadles, K., Reimer, R., Lessner, A., Lewis, K. and Pericak-Vance, M. A.(1995). Blepharophimosis syndrome is linked to chromosome 3q. Hum. Mol. Genet.4,443-448.","DOI":"10.1093\/hmg\/4.3.443"},{"key":"2021042605203109900_REF45","unstructured":"Sperber, G. H. (2001). Craniofacial Development. Hamilton. Ontario: BC Decker."},{"key":"2021042605203109900_REF46","unstructured":"Thesleff, I., Vaahtokari, I. and Partanen, A.-M.(1995). Regulation of organogenesis: Common molecular mechanisms regulating the development of teeth and other organs. Int. J. Dev. Biol.39,35-50."},{"key":"2021042605203109900_REF47","doi-asserted-by":"crossref","unstructured":"Thyagarajan, T., Totey, S., Danton, M. J. and Kulkarni, A. B. (2003). Genetically altered mouse models: the good, the bad, and the ugly. Crit. Rev. Oral Biol. Med.14,154-174.","DOI":"10.1177\/154411130301400302"},{"key":"2021042605203109900_REF48","doi-asserted-by":"crossref","unstructured":"Tonkin, E. T., Wang, T. J., Lisgo, S., Bamshad, M. J. and Strachan, T. (2004). NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion protein and fly Nipped-B, is mutated in Cornelia de Lange syndrome. Nat. Genet.36,636-641.","DOI":"10.1038\/ng1363"},{"key":"2021042605203109900_REF49","doi-asserted-by":"crossref","unstructured":"Van den Boogaard, M.-J. H., Dorland, M., Beemer, F. A. and van Amstel, H. K. P. (2000). MSX1 mutation is associated with orofacial clefting and tooth agenesis in human. Nat. Genet.24,342-343.","DOI":"10.1038\/74155"},{"key":"2021042605203109900_REF50","doi-asserted-by":"crossref","unstructured":"Vastardis, H., Karimbux, N., Guthua, S. W., Seidman, J. G. and Seidman, C. E. (1996). A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat. Genet.13,417-421.","DOI":"10.1038\/ng0896-417"},{"key":"2021042605203109900_REF51","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhao, X., Hu, Y., St Amand, T., Zhang, M.,Ramamurthy, R., Qiu, M. and Chen, Y. P. (1999). Msx1is required for the induction of Patched by Sonic hedgehogin the mammalian tooth germ. Dev. Dyn.215, 45-53.","DOI":"10.1002\/(SICI)1097-0177(199905)215:1<45::AID-DVDY5>3.0.CO;2-5"},{"key":"2021042605203109900_REF52","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, Z., Zhao, X., Yu, X., Hu, Y., Geronimo, B.,Fromm, S. H. and Chen, Y. P. (2000). A new function of BMP4:dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development127,1431-1443.","DOI":"10.1242\/dev.127.7.1431"},{"key":"2021042605203109900_REF53","unstructured":"Zhang, Z., Song, Y., Zhao, X., Zhang, X., Fermin, C. and Chen,Y. P. (2002). Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development129,4135-4146."},{"key":"2021042605203109900_REF54","doi-asserted-by":"crossref","unstructured":"Zhao, X., Zhang, Z., Song, Y., Zhang, X., Zhang, Y., Hu, Y.,Fromm, S. H. and Chen, Y. P. (2000). Transgenically ectopic expression of Bmp4 to Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech. Dev.99, 29-38.","DOI":"10.1016\/S0925-4773(00)00467-6"},{"key":"2021042605203109900_REF55","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Guo, Y. J., Tomac, A. C., Taylor, N. R., Grinberg, A.,Lee, E. J., Huang, S. and Westphal, H. (1999), Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene Lhx8. Proc. Natl. Acad. Sci. USA96,15002-15006.","DOI":"10.1073\/pnas.96.26.15002"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/132\/19\/4397\/1511327\/4397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/132\/19\/4397\/1511327\/4397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:12:48Z","timestamp":1706526768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/132\/19\/4397\/42984\/Shox2-deficient-mice-exhibit-a-rare-type-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,1]]},"references-count":55,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.02013","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10,1]]}}}