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Notably, there is an increased allocation of cells to a neural crest fate and within this lineage, an increase in melanocytes at the expense of cranial ganglia neurons. Most of the observed effects can be attributed to stabilisation of\u03b2-catenin, a known target of Cullin-1-mediated degradation from other systems. Indeed, we show that blocking the function of Cullin-1leads to a decrease in ubiquitinated \u03b2-catenin and an increase in total\u03b2-catenin. Our results show that Cullin-1-mediated protein degradation plays an essential role in the correct allocation of neural crest fates during embryogenesis.<\/jats:p>","DOI":"10.1242\/dev.02201","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T01:13:36Z","timestamp":1136510016000},"page":"559-568","source":"Crossref","is-referenced-by-count":18,"title":["A dominant-negative form of the E3 ubiquitin ligase<i>Cullin-1<\/i>disrupts the correct allocation of cell fate in the neural crest lineage"],"prefix":"10.1242","volume":"133","author":[{"given":"Jana","family":"Voigt","sequence":"first","affiliation":[{"name":"The Wellcome Trust\/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR, UK and Department of Anatomy, Downing Site,University of Cambridge, Cambridge, CB2 3DY, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Papalopulu","sequence":"additional","affiliation":[{"name":"The Wellcome Trust\/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR, UK and Department of Anatomy, Downing Site,University of Cambridge, Cambridge, CB2 3DY, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042605423575300_REF1","doi-asserted-by":"crossref","unstructured":"Aoki, Y., Saint-Germain, N., Gyda, M., Magner-Fink, E., Lee, Y. 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