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Inactivation of both Foxf2alleles, or one allele each of Foxf1 and Foxf2, cause a range of defects, including megacolon, colorectal muscle hypoplasia and agangliosis. Foxf expression in the splanchnic mesoderm is activated by Indian and sonic hedgehog secreted by the epithelium. In Foxf mutants, mesenchymal expression of Bmp4 is reduced, whereas Wnt5a expression is increased. Activation of the canonical Wnt pathway \u2013 with nuclear localization of \u03b2-catenin in epithelial cells \u2013 is associated with over-proliferation and resistance to apoptosis. Extracellular matrix,particularly collagens, is severely reduced in Foxf mutant intestine, which causes epithelial depolarization and tissue disintegration. Thus, Foxf proteins are mesenchymal factors that control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling.<\/jats:p>","DOI":"10.1242\/dev.02252","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T01:39:38Z","timestamp":1138325978000},"page":"833-843","source":"Crossref","is-referenced-by-count":210,"title":["<i>Foxf1<\/i>and<i>Foxf2<\/i>control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production"],"prefix":"10.1242","volume":"133","author":[{"given":"Mattias","family":"Ormestad","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Go\u0308teborg University,Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Astorga","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Go\u0308teborg University,Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Landgren","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Go\u0308teborg University,Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hamamatsu University School of Medicine,Hamamatsu, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt R.","family":"Johansson","sequence":"additional","affiliation":[{"name":"The Electron Microscopy Unit, Department of Anatomy and Cell Biology,Go\u0308teborg University, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hamamatsu University School of Medicine,Hamamatsu, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Go\u0308teborg University,Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605404729600_REF1","doi-asserted-by":"crossref","unstructured":"Aitola, M., Carlsson, P., Mahlapuu, M., Enerback, S. and Pelto-Huikko, M. 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