{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:21Z","timestamp":1791230901854,"version":"4.1.0"},"reference-count":68,"publisher":"The Company of Biologists","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,15]]},"abstract":"<jats:p>The c-Myc protein has been implicated in playing a pivotal role in regulating the expression of a large number of genes involved in many aspects of cellular function. Consistent with this view, embryos lacking the c-myc gene exhibit severe developmental defects and die before midgestation. Here, we show that Sox2Cre-mediated deletion of the conditional c-mycflox allele specifically in the epiblast (hence trophoectoderm and primitive endoderm structures are wild type) rescues the majority of developmental abnormalities previously characterized in c-myc knockout embryos, indicating that they are secondary defects and arise as a result of placental insufficiency. Epiblast-restricted c-Myc-null embryos appear morphologically normal and do not exhibit any obvious proliferation defects. Nonetheless, these embryos are severely anemic and die before E12. c-Myc-deficient embryos exhibit fetal liver hypoplasia,apoptosis of erythrocyte precursors and functionally defective definitive hematopoietic stem\/progenitor cells. Specific deletion of c-mycflox in hemogenic or hepatocytic lineages validate the hematopoietic-specific requirement of c-Myc in the embryo proper and provide in vivo evidence to support a synergism between hematopoietic and liver development. Our results reveal for the first time that physiological levels of c-Myc are essential for cell survival and demonstrate that, in contrast to most other embryonic lineages, erythroblasts and hematopoietic stem\/progenitor cells are particularly dependent on c-Myc function.<\/jats:p>","DOI":"10.1242\/dev.022707","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T01:14:02Z","timestamp":1213319642000},"page":"2455-2465","source":"Crossref","is-referenced-by-count":80,"title":["Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function"],"prefix":"10.1242","volume":"135","author":[{"given":"Nicole C.","family":"Dubois","sequence":"first","affiliation":[{"name":"Ecole Polytechnique Fe\u0301de\u0301rale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Adolphe","sequence":"additional","affiliation":[{"name":"Ecole Polytechnique Fe\u0301de\u0301rale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Ehninger","sequence":"additional","affiliation":[{"name":"Ecole Polytechnique Fe\u0301de\u0301rale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Trumpp","sequence":"additional","affiliation":[{"name":"Ecole Polytechnique Fe\u0301de\u0301rale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605463827600_REF1","doi-asserted-by":"crossref","unstructured":"Adhikary, S. and Eilers, M. 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