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Deletion of the Cebpa gene in respiratory epithelial cells in fetal mice caused respiratory failure at birth. Structural and biochemical maturation of the lung was delayed. Normal synthesis of surfactant lipids and proteins,including SP-A, SP-B, SP-C, SP-D, ABCA3 (a lamellar body associated protein)and FAS (precursor of fatty acid synthesis) were dependent upon expression of the C\/EBP\u03b1 in respiratory epithelial cells. Deletion of the Cebpa gene caused increased expression of Tgfb2, a growth factor that inhibits lung epithelial cell proliferation and differentiation. Normal expression of C\/EBP\u03b1 required Titf1 and Foxa2,transcription factors that also play an important role in perinatal lung differentiation. C\/EBP\u03b1 participates in a transcriptional network that is required for the regulation of genes mediating perinatal lung maturation and surfactant homeostasis that is necessary for adaptation to air breathing at birth.<\/jats:p>","DOI":"10.1242\/dev.02273","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T01:26:17Z","timestamp":1139448377000},"page":"1155-1164","source":"Crossref","is-referenced-by-count":127,"title":["C\/EBP\u03b1 is required for lung maturation at birth"],"prefix":"10.1242","volume":"133","author":[{"given":"Prithy C.","family":"Martis","sequence":"first","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Whitsett","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Karina T.","family":"Perl","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajing","family":"Wan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605443920500_REF1","doi-asserted-by":"crossref","unstructured":"Alam, T., An, M. 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