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Furthermore, nonlinear effects of Fgf8 gene dose on the expression of a subset of genes, including Bmp4 and Msx1, correlate with a holoprosencephaly phenotype and with the nonlinear expression of transcription factors that regulate neocortical patterning. These data suggest that Fgf8 functions to coordinate multiple patterning centers, and that modifications in the relative strength of FGF signaling can have profound effects on the relative size and nature of telencephalic subdivisions.<\/jats:p>","DOI":"10.1242\/dev.02324","type":"journal-article","created":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T20:49:45Z","timestamp":1144874985000},"page":"1831-1844","source":"Crossref","is-referenced-by-count":345,"title":["Dose-dependent functions of\n                    <i>Fgf8<\/i>\n                    in regulating telencephalic patterning centers"],"prefix":"10.1242","volume":"133","author":[{"given":"Elaine E.","family":"Storm","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94143-2711,USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garel","sequence":"additional","affiliation":[{"name":"Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143-2611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Borello","sequence":"additional","affiliation":[{"name":"Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143-2611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Hebert","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Martinez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Alicante CSIC and Universidad Miguel Herna\u0301ndez, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"McConnell","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143-2611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L. 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