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Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb.<\/jats:p>","DOI":"10.1242\/dev.02329","type":"journal-article","created":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T01:24:37Z","timestamp":1142472277000},"page":"1433-1443","source":"Crossref","is-referenced-by-count":73,"title":["Zinc-finger gene<i>Fez<\/i>in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously"],"prefix":"10.1242","volume":"133","author":[{"given":"Tsutomu","family":"Hirata","sequence":"first","affiliation":[{"name":"Laboratory for Vertebrate Axis Formation, Center for Developmental Biology,RIKEN, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Laboratory for Vertebrate Axis Formation, Center for Developmental Biology,RIKEN, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei-ichi","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN,Wako-shi, Saitama 351-0198, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN,Wako-shi, Saitama 351-0198, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hibi","sequence":"additional","affiliation":[{"name":"Laboratory for Vertebrate Axis Formation, Center for Developmental Biology,RIKEN, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605450559000_REF1","unstructured":"Bulfone, A., Puelles, L., Porteus, M. 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