{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:12:22Z","timestamp":1791249142951,"version":"4.1.0"},"reference-count":48,"publisher":"The Company of Biologists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>The enteric nervous system arises mainly from vagal and sacral neural crest cells that colonise the gut between 9.5 and 14 days of development in mice. Using the Cre-LoxP system, we removed \u03b21 integrins in the neural crest cells when they emerge from the neural tube. \u03b21-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover,\u03b21-null enteric neural crest cells form abnormal aggregates in the gut wall, leading to a severe alteration of the ganglia network organisation. Organotypic cultures of gut explants reveal that \u03b21-null enteric neural crest cells show impaired adhesion on extracellular matrix and enhanced intercellular adhesion properties. They display migration defects in collagen gels and gut tissue environments. We also provide evidence that \u03b21 integrins are required for the villi innervation in the small intestine. Our findings highlight the crucial roles played by \u03b21 integrins at various steps of enteric nervous system development.<\/jats:p>","DOI":"10.1242\/dev.02346","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T20:25:14Z","timestamp":1143663914000},"page":"1725-1734","source":"Crossref","is-referenced-by-count":105,"title":["Lack of \u03b21 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype"],"prefix":"10.1242","volume":"133","author":[{"given":"Marie A.","family":"Breau","sequence":"first","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pietri","sequence":"additional","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Eder","sequence":"additional","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Blanche","sequence":"additional","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Brakebusch","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Biochemistry, Department of Molecular Medicine,Martinsried, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhardt","family":"Fa\u0308ssler","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Biochemistry, Department of Molecular Medicine,Martinsried, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Thiery","sequence":"additional","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Dufour","sequence":"additional","affiliation":[{"name":"UMR144, CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05,France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612252655000_REF1","doi-asserted-by":"crossref","unstructured":"Bagnato, A., Rosano, L., Spinella, F., Di Castro, V., Tecce, R. and Natali, P. 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