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We uncovered previously unexpected roles of Ihh signaling in synovial joint formation and the essential function of Wnt\/\u03b2-catenin signaling in regulating chondrocyte survival. More importantly, we found that Wnt and Ihh signaling interact with each other in distinct ways to control osteoblast differentiation, chondrocyte proliferation, hypertrophy, survival and synovial joint formation in the developing endochondral bone. \u03b2-catenin is required downstream of Ihh signaling and osterix expression for osteoblast differentiation. But in chondrocyte survival, \u03b2-catenin is required upstream of Ihh signaling to inhibit chondrocyte apoptosis. In addition, Ihh signaling can inhibit chondrocyte hypertrophy and synovial joint formation independently of\u03b2-catenin. However, there is a strong synergistic interaction between Wnt\/\u03b2-catenin and Ihh signaling in regulating synovial joint formation.<\/jats:p>","DOI":"10.1242\/dev.02546","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T21:13:30Z","timestamp":1156540410000},"page":"3695-3707","source":"Crossref","is-referenced-by-count":179,"title":["Wnt\/\u03b2-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation"],"prefix":"10.1242","volume":"133","author":[{"given":"Kingston Kinglun","family":"Mak","sequence":"first","affiliation":[{"name":"Genetic Disease Research Branch, National Human Genome Research Institute,Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Hsueh","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy F.","family":"Day","sequence":"additional","affiliation":[{"name":"Genetic Disease Research Branch, National Human Genome Research Institute,Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Tien","family":"Chuang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Yang","sequence":"additional","affiliation":[{"name":"Genetic Disease Research Branch, National Human Genome Research Institute,Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612092298700_REF1","doi-asserted-by":"crossref","unstructured":"Akiyama, H., Lyons, J. 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