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Ectopic expression of Shroom2 in nai\u0308ve epithelial cells facilitates apical pigment accumulation, and this activity specifically requires the Rab27a GTPase. Most interestingly, we find that Shroom2, like Shroom3 (previously called Shroom),is sufficient to induce a dramatic apical accumulation of the microtubule-nucleating protein \u03b3-tubulin at the apical surfaces of nai\u0308ve epithelial cells. Together, our data identify Shroom2 as a central regulator of RPE pigmentation, and suggest that, despite their diverse biological roles, Shroom family proteins share a common activity. Finally,because the locus encoding human SHROOM2 lies within the critical region for two distinct forms of ocular albinism, it is possible that SHROOM2mutations may be a contributing factor in these human visual system disorders.<\/jats:p>","DOI":"10.1242\/dev.02563","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:26:27Z","timestamp":1158798387000},"page":"4109-4118","source":"Crossref","is-referenced-by-count":46,"title":["Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium"],"prefix":"10.1242","volume":"133","author":[{"given":"Pamela D.","family":"Fairbank","sequence":"first","affiliation":[{"name":"Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjae","family":"Lee","sequence":"additional","affiliation":[{"name":"Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avegiyel","family":"Ellis","sequence":"additional","affiliation":[{"name":"Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Gross","sequence":"additional","affiliation":[{"name":"Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA."},{"name":"Institute for Neuroscience, University of Texas, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Wallingford","sequence":"additional","affiliation":[{"name":"Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA."},{"name":"Institute for Neuroscience, University of Texas, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042605402691100_REF1","doi-asserted-by":"crossref","unstructured":"Apodaca, G. 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