{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:36:23Z","timestamp":1791272183236,"version":"4.1.0"},"reference-count":21,"publisher":"The Company of Biologists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:p>Dlgh1 (discs large homolog 1) is a mammalian homolog of the Drosophila tumor suppressor Discs large 1, and is a member of the membrane-associated guanylate kinase (MAGUK) scaffolding proteins that contain three PSD-95\/Dlg\/ZO-1 (PDZ) domains. Discs large 1 is involved in epithelial polarization and cell-cell adhesion complex formation during Drosophila development. However, the functions of Dlgh1 during mammalian development remain to be elucidated. We generated Dlgh1-knockout mice and found that homozygous Dlgh1-knockout mice developed various abnormalities in their renal and urogenital organs. The kidneys and ureters were hypoplastic and the lower ends of the ureters were ectopic. In addition, the vagina and seminal vesicle, which are derived from the lower part of the Mu\u0308llerian and Wolffian duct, respectively, were absent. Unexpectedly, loss of Dlgh1 function in the developing ureters did not disrupt cell-cell junctional complexes, but did impair cellular proliferation in the epithelium. These results suggest a novel role for Dlgh1 in regulating epithelial duct formation and morphogenesis during mammalian development. Although congenital absence of the vagina associated with other variable Mu\u0308llerian duct abnormalities has been reported in humans, its mechanism has not yet been clarified. Our findings might contribute to a better understanding of such abnormalities.<\/jats:p>","DOI":"10.1242\/dev.02830","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T16:58:20Z","timestamp":1176483500000},"page":"1799-1807","source":"Crossref","is-referenced-by-count":83,"title":["Abnormal development of urogenital organs in Dlgh1-deficient mice"],"prefix":"10.1242","volume":"134","author":[{"given":"Akiko","family":"Iizuka-Kogo","sequence":"first","affiliation":[{"name":"Department of Anatomy I, Fujita Health University School of Medicine, Toyoake,Aichi 470-1192, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Ishidao","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032,Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032,Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Senda","sequence":"additional","affiliation":[{"name":"Department of Anatomy I, Fujita Health University School of Medicine, Toyoake,Aichi 470-1192, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612331906900_REF1","doi-asserted-by":"crossref","unstructured":"Batourina, E., Choi, C., Paragas, N., Bello, N., Hensle, T.,Costantini, F. D., Schuchardt, A., Bacallao, R. L. and Mendelsohn, C. L.(2002). Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat. Genet.32,109-115.","DOI":"10.1038\/ng952"},{"key":"2021042612331906900_REF2","doi-asserted-by":"crossref","unstructured":"Caruana, G. and Bernstein, A. (2001). Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol. Cell. Biol.21,1475-1483.","DOI":"10.1128\/MCB.21.5.1475-1483.2001"},{"key":"2021042612331906900_REF3","doi-asserted-by":"crossref","unstructured":"Etienne-Manneville, S., Manneville, J. B., Nicholls, S.,Ferenczi, M. A. and Hall, A. (2005). Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. J. Cell Biol.170,895-901.","DOI":"10.1083\/jcb.200412172"},{"key":"2021042612331906900_REF4","doi-asserted-by":"crossref","unstructured":"Firestein, B. L. and Rongo, C. (2001). 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