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These inclusions in chorionic trophoblast cells prevent chorioallantoic attachment during placental development. We show further that keratin-deficient embryos undergo chorioallantoic attachment and that, by genetically reducing keratin expression in Mrj-\/-conceptuses, chorioallantoic attachment was rescued. Therefore, the chorioallantoic attachment phenotype in Mrj mutants is not due to a deficiency of the normal keratin cytoskeleton, but rather is cytotoxicity caused by keratin aggregates that disrupt chorion trophoblast cell organization and function.<\/jats:p>","DOI":"10.1242\/dev.02843","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:14:03Z","timestamp":1175732043000},"page":"1809-1817","source":"Crossref","is-referenced-by-count":55,"title":["The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta"],"prefix":"10.1242","volume":"134","author":[{"given":"Erica D.","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Calgary,Calgary, Alberta, T2N 4N1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Geary-Joo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Calgary,Calgary, Alberta, T2N 4N1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Calgary,Calgary, Alberta, T2N 4N1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Calgary,Calgary, Alberta, T2N 4N1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042612325878700_REF1","doi-asserted-by":"crossref","unstructured":"Bardag-Gorce, F., Riley, N., Nguyen, V., Montgomery, R. 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