{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:22:08Z","timestamp":1791408128763,"version":"4.3.3"},"reference-count":83,"publisher":"The Company of Biologists","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:p>Elucidating the gene regulatory networks that govern pharyngeal arch artery(PAA) development is an important goal, as such knowledge can help to identify new genes involved in cardiovascular disease. The transcription factor Tbx1 plays a vital role in PAA development and is a major contributor to cardiovascular disease associated with DiGeorge syndrome. In this report, we used various genetic approaches to reveal part of a signalling network by which Tbx1 controls PAA development in mice. We investigated the crucial role played by the homeobox-containing transcription factor Gbx2 downstream of Tbx1. We found that PAA formation requires the pharyngeal surface ectoderm as a key signalling centre from which Gbx2, in response to Tbx1, triggers essential directional cues to the adjacent cardiac neural crest cells (cNCCs)en route to the caudal PAAs. Abrogation of this signal generates cNCC patterning defects leading to PAA abnormalities. Finally, we showed that the Slit\/Robo signalling pathway is activated during cNCC migration and that components of this pathway are affected in Gbx2 and Tbx1mutant embryos at the time of PAA development. We propose that the spatiotemporal control of this tightly orchestrated network of genes participates in crucial aspects of PAA development.<\/jats:p>","DOI":"10.1242\/dev.028902","type":"journal-article","created":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T14:01:40Z","timestamp":1250863300000},"page":"3173-3183","source":"Crossref","is-referenced-by-count":144,"title":["Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating\n                    <i>Gbx2<\/i>\n                    expression in the pharyngeal ectoderm"],"prefix":"10.1242","volume":"136","author":[{"given":"Ame\u0301lie","family":"Calmont","sequence":"first","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ivins","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Lammerts","family":"Van Bueren","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinna","family":"Papangeli","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Kyriakopoulou","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University College London,London WC1E 6BT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Technology, Texas A&M Health Science Center,Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Moon","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurobiology and Anatomy and Human Genetics,University of Utah, Salt Lake City, UT 84112, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Illingworth","sequence":"additional","affiliation":[{"name":"Dulbecco Telethon Institute, c\/o Telethon Institute of Genetics and Medicine,Via Pietro Castellino 111, 80131 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Albert","family":"Basson","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development, King's College London, Floor 27, Guy's Tower, London SE1 9RT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Scambler","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042621405953500_REF1","doi-asserted-by":"crossref","unstructured":"Andrews, W., Barber, M., Hernadez-Miranda, L. R., Xian, J.,Rakic, S., Sundaresan, V., Rabbitts, T. H., Pannell, R., Rabbitts, P.,Thompson, H. et al. (2008). The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev. Biol.313,648-658.","DOI":"10.1016\/j.ydbio.2007.10.052"},{"key":"2021042621405953500_REF2","doi-asserted-by":"crossref","unstructured":"Arnold, J. S., Werling, U., Braunstein, E. M., Liao, J.,Nowotschin, S., Edelmann, W., Hebert, J. M. and Morrow, B. E.(2006). Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development133,977-987.","DOI":"10.1242\/dev.02264"},{"key":"2021042621405953500_REF3","doi-asserted-by":"crossref","unstructured":"Barbosky, L., Lawrence, D. K., Karunamuni, G., Wikenheiser, J. C., Doughman, Y. Q., Visconti, R. P., Burch, J. B. and Watanabe, M.(2006). Apoptosis in the developing mouse heart. Dev. Dyn.235,2592-2602.","DOI":"10.1002\/dvdy.20885"},{"key":"2021042621405953500_REF4","doi-asserted-by":"crossref","unstructured":"Bergwerff, M., DeRuiter, M. C., Hall, S., Poelmann, R. E. and Gittenberger-de Groot, A. C. (1999). Unique vascular morphology of the fourth aortic arches: possible implications for pathogenesis of type-B aortic arch interruption and anomalous right subclavian artery. Cardiovasc. Res.44,185-196.","DOI":"10.1016\/S0008-6363(99)00186-8"},{"key":"2021042621405953500_REF5","doi-asserted-by":"crossref","unstructured":"Bockman, D. E. and Kirby, M. L. (1984). Dependence of thymus development on derivatives of the neural crest. Science223,498-500.","DOI":"10.1126\/science.6606851"},{"key":"2021042621405953500_REF6","doi-asserted-by":"crossref","unstructured":"Bouillet, P., Chazaud, C., Oulad-Abdelghani, M., Dolle, P. and Chambon, P. (1995). Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dyn.204,372-382.","DOI":"10.1002\/aja.1002040404"},{"key":"2021042621405953500_REF7","doi-asserted-by":"crossref","unstructured":"Brose, K., Bland, K. S., Wang, K. H., Arnott, D., Henzel, W.,Goodman, C. S., Tessier-Lavigne, M. and Kidd, T. (1999). Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell96,795-806.","DOI":"10.1016\/S0092-8674(00)80590-5"},{"key":"2021042621405953500_REF8","doi-asserted-by":"crossref","unstructured":"Brown, C. B., Feiner, L., Lu, M. M., Li, J., Ma, X., Webber, A. L., Jia, L., Raper, J. A. and Epstein, J. A. (2001). PlexinA2 and semaphorin signaling during cardiac neural crest development. Development128,3071-3080.","DOI":"10.1242\/dev.128.16.3071"},{"key":"2021042621405953500_REF9","doi-asserted-by":"crossref","unstructured":"Brown, C. B., Wenning, J. M., Lu, M. M., Epstein, D. J., Meyers,E. N. and Epstein, J. A. (2004). Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev. Biol.267,190-202.","DOI":"10.1016\/j.ydbio.2003.10.024"},{"key":"2021042621405953500_REF10","doi-asserted-by":"crossref","unstructured":"Byrd, N. A. and Meyers, E. N. (2005). Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev. Biol.284,233-245.","DOI":"10.1016\/j.ydbio.2005.05.023"},{"key":"2021042621405953500_REF11","doi-asserted-by":"crossref","unstructured":"Camurri, L., Mambetisaeva, E., Davies, D., Parnavelas, J.,Sundaresan, V. and Andrews, W. (2005). Evidence for the existence of two Robo3 isoforms with divergent biochemical properties. Mol. Cell. Neurosci.30,485-493.","DOI":"10.1016\/j.mcn.2005.07.014"},{"key":"2021042621405953500_REF12","doi-asserted-by":"crossref","unstructured":"Chan, W. Y., Cheung, C. S., Yung, K. M. and Copp, A. J.(2004). Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect. Development131,3367-3379.","DOI":"10.1242\/dev.01197"},{"key":"2021042621405953500_REF13","doi-asserted-by":"crossref","unstructured":"Chapman, D. L., Garvey, N., Hancock, S., Alexiou, M., Agulnik,S. I., Gibson-Brown, J. J., Cebra-Thomas, J., Bollag, R. J., Silver, L. M. and Papaioannou, V. E. (1996). Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev. Dyn.206,379-390.","DOI":"10.1002\/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO;2-F"},{"key":"2021042621405953500_REF14","doi-asserted-by":"crossref","unstructured":"Crossley, P. H. and Martin, G. R. (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development121,439-451.","DOI":"10.1242\/dev.121.2.439"},{"key":"2021042621405953500_REF15","doi-asserted-by":"crossref","unstructured":"De Bellard, M. E., Rao, Y. and Bronner-Fraser, M.(2003). Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells. J. Cell Biol.162,269-279.","DOI":"10.1083\/jcb.200301041"},{"key":"2021042621405953500_REF16","doi-asserted-by":"crossref","unstructured":"DeRuiter, M. C., Poelmann, R. E., Mentink, M. M., Vaniperen, L. and Gittenberger-de Groot, A. C. (1993). Early formation of the vascular system in quail embryos. Anat. Rec.235,261-274.","DOI":"10.1002\/ar.1092350210"},{"key":"2021042621405953500_REF17","doi-asserted-by":"crossref","unstructured":"Feiner, L., Webber, A. L., Brown, C. B., Lu, M. M., Jia, L.,Feinstein, P., Mombaerts, P., Epstein, J. A. and Raper, J. A.(2001). Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development128,3061-3070.","DOI":"10.1242\/dev.128.16.3061"},{"key":"2021042621405953500_REF18","unstructured":"Frank, D. U., Fotheringham, L. K., Brewer, J. A., Muglia, L. J.,Tristani-Firouzi, M., Capecchi, M. R. and Moon, A. M. (2002). An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development129,4591-4603."},{"key":"2021042621405953500_REF19","doi-asserted-by":"crossref","unstructured":"Garg, V., Yamagishi, C., Hu, T., Kathiriya, I. S., Yamagishi, H. and Srivastava, D. (2001). Tbx1, a DiGeorge Syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev. Biol.235, 62-73.","DOI":"10.1006\/dbio.2001.0283"},{"key":"2021042621405953500_REF20","doi-asserted-by":"crossref","unstructured":"Guris, D. L., Duester, G., Papaioannou, V. E. and Imamoto,A. (2006). Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev. Cell10,81-92.","DOI":"10.1016\/j.devcel.2005.12.002"},{"key":"2021042621405953500_REF21","doi-asserted-by":"crossref","unstructured":"High, F. A., Zhang, M., Proweller, A., Tu, L., Parmacek, M. S.,Pear, W. S. and Epstein, J. A. (2007). An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J. Clin. Invest.117,353-363.","DOI":"10.1172\/JCI30070"},{"key":"2021042621405953500_REF22","doi-asserted-by":"crossref","unstructured":"Hu, T., Yamagishi, H., Maeda, J., McAnally, J., Yamagishi, C. and Srivastava, D. (2004). Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development131,5491-5502.","DOI":"10.1242\/dev.01399"},{"key":"2021042621405953500_REF23","doi-asserted-by":"crossref","unstructured":"Ivins, S., Lammerts van Beuren, K., Roberts, C., James, C.,Lindsay, E., Baldini, A., Ataliotis, P. and Scambler, P. J.(2005). Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev. Biol.285,554-569.","DOI":"10.1016\/j.ydbio.2005.06.026"},{"key":"2021042621405953500_REF24","doi-asserted-by":"crossref","unstructured":"Jerome, L. A. and Papaioannou, V. E. (2001). DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet.27,286-291.","DOI":"10.1038\/85845"},{"key":"2021042621405953500_REF25","doi-asserted-by":"crossref","unstructured":"Jia, L., Cheng, L. and Raper, J. (2005). Slit\/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. Dev. Biol.282,411-421.","DOI":"10.1016\/j.ydbio.2005.03.021"},{"key":"2021042621405953500_REF26","doi-asserted-by":"crossref","unstructured":"Jiang, X., Rowitch, D. H., Soriano, P., McMahon, A. P. and Sucov, H. M. (2000). Fate of the mammalian cardiac neural crest. Development127,1607-1616.","DOI":"10.1242\/dev.127.8.1607"},{"key":"2021042621405953500_REF27","doi-asserted-by":"crossref","unstructured":"Jones, C. A., London, N. R., Chen, H., Park, K. W., Sauvaget,D., Stockton, R. A., Wythe, J. D., Suh, W., Larrieu-Lahargue, F., Mukouyama,Y. S. et al. (2008). Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med.14,448-453.","DOI":"10.1038\/nm1742"},{"key":"2021042621405953500_REF28","doi-asserted-by":"crossref","unstructured":"Kirby, M. L. and Waldo, K. L. (1995). Neural crest and cardiovascular patterning. Circ. Res.77,211-215.","DOI":"10.1161\/01.RES.77.2.211"},{"key":"2021042621405953500_REF29","doi-asserted-by":"crossref","unstructured":"Kirby, M. L., Gale, T. F. and Stewart, D. E.(1983). Neural crest cells contribute to normal aorticopulmonary septation. Science220,1059-1061.","DOI":"10.1126\/science.6844926"},{"key":"2021042621405953500_REF30","doi-asserted-by":"crossref","unstructured":"Kirby, M. L., Turnage, K. L., 3rd and Hays, B. M.(1985). Characterization of conotruncal malformations following ablation of `cardiac' neural crest. Anat. Rec.213, 87-93.","DOI":"10.1002\/ar.1092130112"},{"key":"2021042621405953500_REF31","doi-asserted-by":"crossref","unstructured":"Kochilas, L., Merscher-Gomez, S., Lu, M. M., Potluri, V., Liao,J., Kucherlapati, R., Morrow, B. and Epstein, J. A. (2002). The role of neural crest during cardiac development in a mouse model of DiGeorge Syndrome. Dev. Biol.251,157-166.","DOI":"10.1006\/dbio.2002.0819"},{"key":"2021042621405953500_REF32","doi-asserted-by":"crossref","unstructured":"Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I. and Wegner, M. (1998). Sox10, a novel transcriptional modulator in glial cells. J. Neurosci.18,237-250.","DOI":"10.1523\/JNEUROSCI.18-01-00237.1998"},{"key":"2021042621405953500_REF33","doi-asserted-by":"crossref","unstructured":"Le Douarin, N. M. and Kalcheim, C. (1999). The Neural Crest, 2nd edn. Cambridge: Cambridge University Press.","DOI":"10.1017\/CBO9780511897948"},{"key":"2021042621405953500_REF34","doi-asserted-by":"crossref","unstructured":"Le Lievre, C. S. and Le Douarin, N. M. (1975). Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos. J. Embryol. Exp. Morphol.34,125-154.","DOI":"10.1242\/dev.34.1.125"},{"key":"2021042621405953500_REF35","doi-asserted-by":"crossref","unstructured":"Li, J. Y. H., Lao, Z. and Joyner, A. L. (2002). Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid\/hindbrain organizer. Neuron36, 31-43.","DOI":"10.1016\/S0896-6273(02)00935-2"},{"key":"2021042621405953500_REF36","doi-asserted-by":"crossref","unstructured":"Liao, J., Aggarwal, V. S., Nowotschin, S., Bondarev, A., Lipner,S. and Morrow, B. E. (2008). Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev. Biol.316,524-537.","DOI":"10.1016\/j.ydbio.2008.01.037"},{"key":"2021042621405953500_REF37","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A. (2001). Chromosomal microdeletions: dissecting del22q11 syndrome. Nat. Rev. Genet.2,858-868.","DOI":"10.1038\/35098574"},{"key":"2021042621405953500_REF38","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A. and Baldini, A. (2001). Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region. Hum. Mol. Genet.10,997-1002.","DOI":"10.1093\/hmg\/10.9.997"},{"key":"2021042621405953500_REF39","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A., Botta, A., Jurecic, V., Carattini-Rivera, S.,Cheah, Y. C., Rosenblatt, H. M., Bradley, A. and Baldini, A.(1999). Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature401,379-383.","DOI":"10.1038\/43900"},{"key":"2021042621405953500_REF40","doi-asserted-by":"crossref","unstructured":"Lindsay, E. A., Vitelli, F., Su, H., Morishima, M., Huynh, T.,Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H. F., Scambler, P. J. et al. (2001). Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature410,97-101.","DOI":"10.1038\/35065105"},{"key":"2021042621405953500_REF41","doi-asserted-by":"crossref","unstructured":"Liu, A., Losos, K. and Joyner, A. L. (1999). FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development126,4827-4838.","DOI":"10.1242\/dev.126.21.4827"},{"key":"2021042621405953500_REF42","doi-asserted-by":"crossref","unstructured":"Macatee, T. L., Hammond, B. P., Arenkiel, B. R., Francis, L.,Frank, D. U. and Moon, A. M. (2003). Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development130,6361-6374.","DOI":"10.1242\/dev.00850"},{"key":"2021042621405953500_REF43","doi-asserted-by":"crossref","unstructured":"Merscher, S., Funke, B., Epstein, J. A., Heyer, J., Puech, A.,Lu, M. M., Xavier, R. J., Demay, M. B., Russell, R. G., Factor, S. et al.(2001). TBX1 is responsible for cardiovascular defects in velo-cardio-facial\/DiGeorge syndrome. Cell104,619-629.","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"2021042621405953500_REF44","doi-asserted-by":"crossref","unstructured":"Meyers, E. N., Lewandoski, M. and Martin, G. R.(1998). An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet.18,136-141.","DOI":"10.1038\/ng0298-136"},{"key":"2021042621405953500_REF45","doi-asserted-by":"crossref","unstructured":"Mitchell, P. J., Timmons, P. M., Hebert, J. M., Rigby, P. W. and Tjian, R. (1991). Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev.5,105-119.","DOI":"10.1101\/gad.5.1.105"},{"key":"2021042621405953500_REF46","doi-asserted-by":"crossref","unstructured":"Miyagawa-Tomita, S., Waldo, K., Tomita, H. and Kirby, M. L.(1991). Temporospatial study of the migration and distribution of cardiac neural crest in quail-chick chimeras. Am. J. Anat.192,79-88.","DOI":"10.1002\/aja.1001920109"},{"key":"2021042621405953500_REF47","unstructured":"Nagy, A., Gertsenstein, M., Vintersten, K. and Behringer, R.(2003). Manipulating The Mouse Embryo: A Laboratory Manual, 3rd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press."},{"key":"2021042621405953500_REF48","doi-asserted-by":"crossref","unstructured":"Nishibatake, M., Kirby, M. L. and van Mierop, L. H.(1987). Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation. Circulation75,255-264.","DOI":"10.1161\/01.CIR.75.1.255"},{"key":"2021042621405953500_REF49","doi-asserted-by":"crossref","unstructured":"Park, K. W., Morrison, C. M., Sorensen, L. K., Jones, C. A.,Rao, Y., Chien, C. B., Wu, J. Y., Urness, L. D. and Li, D. Y.(2003). Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev. Biol.261,251-267.","DOI":"10.1016\/S0012-1606(03)00258-6"},{"key":"2021042621405953500_REF50","doi-asserted-by":"crossref","unstructured":"Paylor, R., Glaser, B., Mupo, A., Ataliotis, P., Spencer, C.,Sobotka, A., Sparks, C., Choi, C. H., Oghalai, J., Curran, S. et al.(2006). Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc. Natl. Acad. Sci. USA103,7729-7734.","DOI":"10.1073\/pnas.0600206103"},{"key":"2021042621405953500_REF51","doi-asserted-by":"crossref","unstructured":"Peirson, S. N., Butler, J. N. and Foster, R. G.(2003). Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res.31,e73.","DOI":"10.1093\/nar\/gng073"},{"key":"2021042621405953500_REF52","doi-asserted-by":"crossref","unstructured":"Plachez, C., Andrews, W., Liapi, A., Knoell, B., Drescher, U.,Mankoo, B., Zhe, L., Mambetisaeva, E., Annan, A., Bannister, L. et al.(2008). Robos are required for the correct targeting of retinal ganglion cell axons in the visual pathway of the brain. Mol. Cell. Neurosci.37,719-730.","DOI":"10.1016\/j.mcn.2007.12.017"},{"key":"2021042621405953500_REF53","doi-asserted-by":"crossref","unstructured":"Plump, A. S., Erskine, L., Sabatier, C., Brose, K., Epstein, C. J., Goodman, C. S., Mason, C. A. and Tessier-Lavigne, M.(2002). Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. 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Nature407,221-226.","DOI":"10.1038\/35025190"},{"key":"2021042621405953500_REF60","doi-asserted-by":"crossref","unstructured":"Stalmans, I., Lambrechts, D., De, S. F., Jansen, S., Wang, J.,Maity, S., Kneer, P., von der, O. M., Swillen, A., Maes, C. et al.(2003). VEGF: a modifier of the del22q11 (DiGeorge) syndrome?Nat. Med.9,173-182.","DOI":"10.1038\/nm819"},{"key":"2021042621405953500_REF61","doi-asserted-by":"crossref","unstructured":"Stoller, J. Z. and Epstein, J. A. (2005). Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Hum. Mol. Genet.14,885-892.","DOI":"10.1093\/hmg\/ddi081"},{"key":"2021042621405953500_REF62","doi-asserted-by":"crossref","unstructured":"Sundaresan, V., Mambetisaeva, E., Andrews, W., Annan, A., Knoll,B., Tear, G. and Bannister, L. (2004). Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system. J. Comp. Neurol.468,467-481.","DOI":"10.1002\/cne.10984"},{"key":"2021042621405953500_REF63","doi-asserted-by":"crossref","unstructured":"Suzuki, H. R. and Kirby, M. L. (1997). Absence of neural crest cell regeneration from the postotic neural tube. Dev. Biol.184,222-233.","DOI":"10.1006\/dbio.1997.8529"},{"key":"2021042621405953500_REF64","doi-asserted-by":"crossref","unstructured":"Taddei, I., Morishima, M., Huynh, T. and Lindsay, E. A.(2001). Genetic factors are major determinants of phenotypic variability in a mouse model of the DiGeorge\/del22q11 syndromes. Proc. Natl. Acad. Sci. USA98,11428-11431.","DOI":"10.1073\/pnas.201127298"},{"key":"2021042621405953500_REF65","doi-asserted-by":"crossref","unstructured":"Tamada, A., Kumada, T., Zhu, Y., Matsumoto, T., Hatanaka, Y.,Muguruma, K., Chen, Z., Tanabe, Y., Torigoe, M., Yamauchi, K. et al.(2008). Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev.3,29.","DOI":"10.1186\/1749-8104-3-29"},{"key":"2021042621405953500_REF66","doi-asserted-by":"crossref","unstructured":"Teng, L., Mundell, N. A., Frist, A. Y., Wang, Q. and Labosky, P. A. (2008). Requirement for Foxd3 in the maintenance of neural crest progenitors. Development135,1615-1624.","DOI":"10.1242\/dev.012179"},{"key":"2021042621405953500_REF67","doi-asserted-by":"crossref","unstructured":"Toyofuku, T., Yoshida, J., Sugimoto, T., Yamamoto, M., Makino,N., Takamatsu, H., Takegahara, N., Suto, F., Hori, M., Fujisawa, H. et al.(2008). Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells. Dev. Biol.321,251-262.","DOI":"10.1016\/j.ydbio.2008.06.028"},{"key":"2021042621405953500_REF68","doi-asserted-by":"crossref","unstructured":"Trainor, P. A. (2005). Specification of neural crest cell formation and migration in mouse embryos. Semin. Cell Dev. Biol.16,683-693.","DOI":"10.1016\/j.semcdb.2005.06.007"},{"key":"2021042621405953500_REF69","doi-asserted-by":"crossref","unstructured":"Trainor, P. and Krumlauf, R. (2000). Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm. Nat. Cell Biol.2, 96-102.","DOI":"10.1038\/35000051"},{"key":"2021042621405953500_REF70","doi-asserted-by":"crossref","unstructured":"Vitelli, F., Morishima, M., Taddei, I., Lindsay, E. A. and Baldini, A. (2002a). Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum. Mol. Genet.11,915-922.","DOI":"10.1093\/hmg\/11.8.915"},{"key":"2021042621405953500_REF71","doi-asserted-by":"crossref","unstructured":"Vitelli, F., Taddei, I., Morishima, M., Meyers, E. N., Lindsay,E. A. and Baldini, A. (2002b). A genetic link between Tbx1 and fibroblast growth factor signaling. Development129,4605-4611.","DOI":"10.1242\/dev.129.19.4605"},{"key":"2021042621405953500_REF72","doi-asserted-by":"crossref","unstructured":"Wassarman, K. M., Lewandoski, M., Campbell, K., Joyner, A. L.,Rubenstein, J. L., Martinez, S. and Martin, G. R. (1997). Specification of the anterior hindbrain and establishment of a normal mid\/hindbrain organizer is dependent on Gbx2 gene function. Development124,2923-2934.","DOI":"10.1242\/dev.124.15.2923"},{"key":"2021042621405953500_REF73","unstructured":"Wilkinson, D. (1992). In Situ Hybridisation: A Practical Approach. Oxford: IRL Press."},{"key":"2021042621405953500_REF74","doi-asserted-by":"crossref","unstructured":"Xu, H., Morishima, M., Wylie, J. N., Schwartz, R. J., Bruneau,B. G., Lindsay, E. A. and Baldini, A. (2004). Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development131,3217-3227.","DOI":"10.1242\/dev.01174"},{"key":"2021042621405953500_REF75","doi-asserted-by":"crossref","unstructured":"Xu, H., Cerrato, F. and Baldini, A. (2005). Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development132,4387-4395.","DOI":"10.1242\/dev.02018"},{"key":"2021042621405953500_REF76","doi-asserted-by":"crossref","unstructured":"Xu, H., Viola, A., Zhang, Z., Gerken, C. P.,Lindsay-Illingworth, E. A. and Baldini, A. (2007). Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev. Biol.302,670-682.","DOI":"10.1016\/j.ydbio.2006.10.002"},{"key":"2021042621405953500_REF77","doi-asserted-by":"crossref","unstructured":"Yagi, H., Furutani, Y., Hamada, H., Sasaki, T., Asakawa, S.,Minoshima, S., Ichida, F., Joo, K., Kimura, M., Imamura, S. et al.(2003). Role of TBX1 in human del22q11.2 syndrome. Lancet.362,1366-1373.","DOI":"10.1016\/S0140-6736(03)14632-6"},{"key":"2021042621405953500_REF78","doi-asserted-by":"crossref","unstructured":"Yamagishi, H., Maeda, J., Hu, T., McAnally, J., Conway, S. J.,Kume, T., Meyers, E. N., Yamagishi, C. and Srivastava, D.(2003). Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev.17,269-281.","DOI":"10.1101\/gad.1048903"},{"key":"2021042621405953500_REF79","doi-asserted-by":"crossref","unstructured":"Yuan, W., Zhou, L., Chen, J. H., Wu, J. Y., Rao, Y. and Ornitz,D. M. (1999). The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol.212,290-306.","DOI":"10.1006\/dbio.1999.9371"},{"key":"2021042621405953500_REF80","unstructured":"Zhang, Z. and Baldini, A. (2008). In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum. Mol. 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