{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:39:04Z","timestamp":1790620744161,"version":"4.1.0"},"reference-count":65,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>During embryogenesis, the pancreas develops from separate dorsal and ventral buds, which fuse to form the mature pancreas. Little is known about the functional differences between these two buds or the relative contribution of cells derived from each region to the pancreas after fusion. To follow the fate of dorsal or ventral bud derived cells in the pancreas after fusion, we produced chimeric Elas-GFP transgenic\/wild-type embryos in which either dorsal or ventral pancreatic bud cells expressed GFP. We found that ventral pancreatic cells migrate extensively into the dorsal pancreas after fusion,whereas the converse does not occur. Moreover, we found that annular pancreatic tissue is composed exclusively of ventral pancreas-derived cells. To identify ventral pancreas-specific genes that may play a role in pancreatic bud fusion, we isolated individual dorsal and ventral pancreatic buds, prior to fusion, from NF38\/39 Xenopus laevis tadpoles and compared their gene expression profiles (NF refers to the specific stage of Xenopusdevelopment). As a result of this screen, we have identified several new ventral pancreas-specific genes, all of which are expressed in the same location within the ventral pancreas at the junction where the two ventral pancreatic buds fuse. Morpholino-mediated knockdown of one of these ventral-specific genes, transmembrane 4 superfamily member 3(tm4sf3), inhibited dorsal-ventral pancreatic bud fusion, as well as acinar cell differentiation. Conversely, overexpression of tm4sf3promoted development of annular pancreas. Our results are the first to define molecular and behavioral differences between the dorsal and ventral pancreas,and suggest an unexpected role for the ventral pancreas in pancreatic bud fusion.<\/jats:p>","DOI":"10.1242\/dev.032235","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T00:45:17Z","timestamp":1241052317000},"page":"1791-1800","source":"Crossref","is-referenced-by-count":40,"title":["The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds"],"prefix":"10.1242","volume":"136","author":[{"given":"Zeina","family":"Jarikji","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montre\u0301al, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada."},{"name":"Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l'Universite\u0301 de Montre\u0301al, Montreal, QC H1W 4A4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori Dawn","family":"Horb","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montre\u0301al, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada."},{"name":"Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l'Universite\u0301 de Montre\u0301al, Montreal, QC H1W 4A4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Shariff","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montre\u0301al, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Mandato","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology and Division of Experimental Medicine,McGill University, Montreal, QC Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken W. Y.","family":"Cho","sequence":"additional","affiliation":[{"name":"Developmental Biology Center and the Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko E.","family":"Horb","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montre\u0301al, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada."},{"name":"Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l'Universite\u0301 de Montre\u0301al, Montreal, QC H1W 4A4, Canada."},{"name":"Department of Anatomy and Cell Biology and Division of Experimental Medicine,McGill University, Montreal, QC Canada."},{"name":"De\u0301partement de me\u0301decine, Universite\u0301 de Montre\u0301al,Montre\u0301al, QC H3T 3J7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042621302646800_REF1","doi-asserted-by":"crossref","unstructured":"Afelik, S., Chen, Y. and Pieler, T. (2004). Pancreatic protein disulfide isomerase (XPDIp) is an early marker for the exocrine lineage of the developing pancreas in Xenopus laevis embryos. Gene Expr. Patterns4,71-76.","DOI":"10.1016\/S1567-133X(03)00150-9"},{"key":"2021042621302646800_REF2","unstructured":"Agha, F. P. and Williams, K. D. (1987). Pancreas divisum: incidence, detection, and clinical significance. Am. J. Gastroenterol.82,315-320."},{"key":"2021042621302646800_REF3","doi-asserted-by":"crossref","unstructured":"Baldwin, W. M. (1910). A specimen of annular pancreas. Anat. Rec.4,299-304.","DOI":"10.1002\/ar.1090040804"},{"key":"2021042621302646800_REF4","doi-asserted-by":"crossref","unstructured":"Beck, C. W. and Slack, J. M. (1999). Gut specific expression using mammalian promoters in transgenic Xenopus laevis. Mech. Dev.88,221-227.","DOI":"10.1016\/S0925-4773(99)00217-8"},{"key":"2021042621302646800_REF5","doi-asserted-by":"crossref","unstructured":"Bencosme, S. A. and Liepa, E. (1955). Regional differences of the pancreatic islet. Endocrinology57,588-593.","DOI":"10.1210\/endo-57-5-588"},{"key":"2021042621302646800_REF6","doi-asserted-by":"crossref","unstructured":"Berditchevski, F. (2001). Complexes of tetraspanins with integrins: more than meets the eye. J. Cell Sci.114,4143-4151.","DOI":"10.1242\/jcs.114.23.4143"},{"key":"2021042621302646800_REF7","doi-asserted-by":"crossref","unstructured":"Berditchevski, F. and Odintsova, E. (2007). Tetraspanins as regulators of protein trafficking. Traffic8,89-96.","DOI":"10.1111\/j.1600-0854.2006.00515.x"},{"key":"2021042621302646800_REF8","doi-asserted-by":"crossref","unstructured":"Blitz, I. L., Andelfinger, G. and Horb, M. E.(2006). Germ layers to organs: using Xenopus to study `later'development. Semin. Cell Dev. Biol.17,133-145.","DOI":"10.1016\/j.semcdb.2005.11.002"},{"key":"2021042621302646800_REF9","doi-asserted-by":"crossref","unstructured":"Bort, R., Martinez-Barbera, J. P., Beddington, R. S. and Zaret,K. S. (2004). Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development131,797-806.","DOI":"10.1242\/dev.00965"},{"key":"2021042621302646800_REF10","doi-asserted-by":"crossref","unstructured":"Cano, D. A., Hebrok, M. and Zenker, M. (2007). Pancreatic development and disease. Gastroenterology132,745-762.","DOI":"10.1053\/j.gastro.2006.12.054"},{"key":"2021042621302646800_REF11","doi-asserted-by":"crossref","unstructured":"Chalmers, A. D. and Slack, J. M. (1998). Development of the gut in Xenopus laevis. Dev. Dyn.212,509-521.","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<509::AID-AJA4>3.0.CO;2-L"},{"key":"2021042621302646800_REF12","doi-asserted-by":"crossref","unstructured":"Chalmers, A. D. and Slack, J. M. (2000). The Xenopus tadpole gut: fate maps and morphogenetic movements. Development127,381-392.","DOI":"10.1242\/dev.127.2.381"},{"key":"2021042621302646800_REF13","doi-asserted-by":"crossref","unstructured":"Claas, C., Seiter, S., Claas, A., Savelyeva, L., Schwab, M. and Zoller, M. (1998). Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. J. Cell Biol.141,267-280.","DOI":"10.1083\/jcb.141.1.267"},{"key":"2021042621302646800_REF14","unstructured":"Claas, C., Wahl, J., Orlicky, D. J., Karaduman, H., Schnolzer,M., Kempf, T. and Zoller, M. (2005). The tetraspanin D6.1A and its molecular partners on rat carcinoma cells. Biochem. J.389,99-110."},{"key":"2021042621302646800_REF15","unstructured":"Delmas, A. (1939). Les e\u0301bauches pancre\u0301atiques dorsales et ventrales. Leurs rapports dans la constitution du pancre\u0301as de\u0301finitif. Ann. Anat. Pathol.16,253-266."},{"key":"2021042621302646800_REF16","doi-asserted-by":"crossref","unstructured":"Deutsch, G., Jung, J., Zheng, M., Lora, J. and Zaret, K. S.(2001). A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development128,871-881.","DOI":"10.1242\/dev.128.6.871"},{"key":"2021042621302646800_REF17","doi-asserted-by":"crossref","unstructured":"Edgar, R., Domrachev, M. and Lash, A. E.(2002). Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res.30,207-210.","DOI":"10.1093\/nar\/30.1.207"},{"key":"2021042621302646800_REF18","doi-asserted-by":"crossref","unstructured":"Gesierich, S., Paret, C., Hildebrand, D., Weitz, J., Zgraggen,K., Schmitz-Winnenthal, F. H., Horejsi, V., Yoshie, O., Herlyn, D., Ashman, L. K. et al. (2005). Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin. Cancer Res.11,2840-2852.","DOI":"10.1158\/1078-0432.CCR-04-1935"},{"key":"2021042621302646800_REF19","doi-asserted-by":"crossref","unstructured":"Gilinsky, N. H., Del Favero, G., Cotton, P. B. and Lees, W. R. (1985). Congenital short pancreas: a report of two cases. Gut26,304-310.","DOI":"10.1136\/gut.26.3.304"},{"key":"2021042621302646800_REF20","doi-asserted-by":"crossref","unstructured":"Gu, G., Wells, J. M., Dombkowski, D., Preffer, F., Aronow, B. and Melton, D. A. (2004). Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development131,165-179.","DOI":"10.1242\/dev.00921"},{"key":"2021042621302646800_REF21","doi-asserted-by":"crossref","unstructured":"Guilbault, C., Novak, J. P., Martin, P., Boghdady, M. L., Saeed,Z., Guiot, M. C., Hudson, T. J. and Radzioch, D. (2006). Distinct pattern of lung gene expression in the Cftr-KO mice developing spontaneous lung disease compared with their littermate controls. Physiol. Genomics25,179-193.","DOI":"10.1152\/physiolgenomics.00206.2005"},{"key":"2021042621302646800_REF22","unstructured":"Guntz, M., Albaret, P., Joubaud, F. and Francois, H.(1976). Absence du corps et de la queue du pancre\u0301as et pancre\u0301atite chronique calcifiante. Pancre\u0301atectomie `totale'. Sem. Hop.52,1863-1867."},{"key":"2021042621302646800_REF23","unstructured":"Gurson, C. T., Tahsinoglu, M., Yakacikli, S. and Ertugrul,T. (1970). A case of agenesis of the dorsal pancreas with interventricular septal defect in an infant. Helv. Paediatr. Acta25,522-526."},{"key":"2021042621302646800_REF24","doi-asserted-by":"crossref","unstructured":"Hebrok, M., Kim, S. K., St Jacques, B., McMahon, A. P. and Melton, D. A. (2000). Regulation of pancreas development by hedgehog signaling. Development127,4905-4913.","DOI":"10.1242\/dev.127.22.4905"},{"key":"2021042621302646800_REF25","doi-asserted-by":"crossref","unstructured":"Hemler, M. E. (2005). Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol.6, 801-811.","DOI":"10.1038\/nrm1736"},{"key":"2021042621302646800_REF26","unstructured":"Herlevsen, M., Schmidt, D. S., Miyazaki, K. and Zoller, M.(2003). The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation. J. Cell Sci.116,4373-4390."},{"key":"2021042621302646800_REF27","doi-asserted-by":"crossref","unstructured":"Horb, M. E. and Slack, J. M. (2002). Expression of amylase and other pancreatic genes in Xenopus. Mech. Dev.113,153-157.","DOI":"10.1016\/S0925-4773(02)00019-9"},{"key":"2021042621302646800_REF28","doi-asserted-by":"crossref","unstructured":"Horb, M. E., Shen, C. N., Tosh, D. and Slack, J. M.(2003). Experimental conversion of liver to pancreas. Curr. Biol.13,105-115.","DOI":"10.1016\/S0960-9822(02)01434-3"},{"key":"2021042621302646800_REF29","doi-asserted-by":"crossref","unstructured":"Jarikji, Z. H., Vanamala, S., Beck, C. W., Wright, C. V., Leach,S. D. and Horb, M. E. (2007). Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev. Biol.304,786-799.","DOI":"10.1016\/j.ydbio.2007.01.027"},{"key":"2021042621302646800_REF30","doi-asserted-by":"crossref","unstructured":"Jimenez, J. C., Emil, S., Podnos, Y. and Nguyen, N.(2004). Annular pancreas in children: a recent decade's experience. J. Pediatr. Surg.39,1654-1657.","DOI":"10.1016\/j.jpedsurg.2004.07.003"},{"key":"2021042621302646800_REF31","unstructured":"Kamisawa, T., Yuyang, T., Egawa, N., Ishiwata, J. and Okamoto,A. (2001). A new embryologic hypothesis of annular pancreas. Hepatogastroenterology48,277-278."},{"key":"2021042621302646800_REF32","doi-asserted-by":"crossref","unstructured":"Kelly, O. G. and Melton, D. A. (2000). Development of the pancreas in Xenopus laevis. Dev. Dyn.218,615-627.","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1027>3.0.CO;2-8"},{"key":"2021042621302646800_REF33","unstructured":"Kim, S. K., Hebrok, M. and Melton, D. A.(1997). Pancreas development in the chick embryo. Cold Spring Harb. Symp. Quant. Biol.62,377-383."},{"key":"2021042621302646800_REF34","doi-asserted-by":"crossref","unstructured":"Klein, S. D. and Affronti, J. P. (2004). Pancreas divisum, an evidence-based review: part I, pathophysiology. Gastrointest. Endosc.60,419-425.","DOI":"10.1016\/S0016-5107(04)01815-2"},{"key":"2021042621302646800_REF35","doi-asserted-by":"crossref","unstructured":"Klein, W. A., Dabezies, M. A., Friedman, A. C., Caroline, D. F.,Boden, G. H. and Cohen, S. (1994). Agenesis of dorsal pancreas in a patient with weight loss and diabetes mellitus. Dig. Dis. Sci39,1708-1713.","DOI":"10.1007\/BF02087781"},{"key":"2021042621302646800_REF36","doi-asserted-by":"crossref","unstructured":"Kumar, M. and Melton, D. (2003). Pancreas specification: a budding question. Curr. Opin. Genet. Dev.13,401-407.","DOI":"10.1016\/S0959-437X(03)00089-3"},{"key":"2021042621302646800_REF37","doi-asserted-by":"crossref","unstructured":"Ladd, A. P. and Madura, J. A. (2001). Congenital duodenal anomalies in the adult. Arch. Surg.136,576-584.","DOI":"10.1001\/archsurg.136.5.576"},{"key":"2021042621302646800_REF38","doi-asserted-by":"crossref","unstructured":"Lammert, E., Cleaver, O. and Melton, D. (2001). Induction of pancreatic differentiation by signals from blood vessels. Science294,564-567.","DOI":"10.1126\/science.1064344"},{"key":"2021042621302646800_REF39","doi-asserted-by":"crossref","unstructured":"Lazo, P. A. (2007). Functional implications of tetraspanin proteins in cancer biology. Cancer Sci.98,1666-1677.","DOI":"10.1111\/j.1349-7006.2007.00584.x"},{"key":"2021042621302646800_REF40","unstructured":"Lecco, T. M. (1910). Zu\u0308r morphologie des Pankreas annulare. Sitzungsb. Akad. Wissensch.119,391-406."},{"key":"2021042621302646800_REF41","doi-asserted-by":"crossref","unstructured":"Lechner, G. W. and Read, R. C. (1966). Agenesis of the dorsal pancreas in an adult diabetic presenting with duodenal ileus. Ann. Surg.163,311-314.","DOI":"10.1097\/00000658-196602000-00025"},{"key":"2021042621302646800_REF42","doi-asserted-by":"crossref","unstructured":"Levy, S. and Shoham, T. (2005a). Protein-protein interactions in the tetraspanin web. Physiology(Bethesda)20,218-224.","DOI":"10.1152\/physiol.00015.2005"},{"key":"2021042621302646800_REF43","doi-asserted-by":"crossref","unstructured":"Levy, S. and Shoham, T. (2005b). The tetraspanin web modulates immune-signalling complexes. Nat. Rev. Immunol.5,136-148.","DOI":"10.1038\/nri1548"},{"key":"2021042621302646800_REF44","doi-asserted-by":"crossref","unstructured":"Lewis, F. T. (1911). The bi-lobed form of the ventral pancreas in mammals. Am. J. Anat.12,389-400.","DOI":"10.1002\/aja.1000120305"},{"key":"2021042621302646800_REF45","doi-asserted-by":"crossref","unstructured":"Liu, L., He, B., Liu, W. M., Zhou, D., Cox, J. V. and Zhang, X. A. (2007). Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J. Biol. Chem.282,31631-31642.","DOI":"10.1074\/jbc.M701165200"},{"key":"2021042621302646800_REF46","unstructured":"Nieuwkoop, P. D. and Faber, J. (1967).Normal table of Xenopus laevis (Daudin), 2nd edn. Amsterdam, The Netherlands: North Holland"},{"key":"2021042621302646800_REF47","doi-asserted-by":"crossref","unstructured":"Novak, J. P., Sladek, R. and Hudson, T. J.(2002). Characterization of variability in large-scale gene expression data: implications for study design. Genomics79,104-113.","DOI":"10.1006\/geno.2001.6675"},{"key":"2021042621302646800_REF48","doi-asserted-by":"crossref","unstructured":"Novak, J. P., Kim, S. Y., Xu, J., Modlich, O., Volsky, D. J.,Honys, D., Slonczewski, J. L., Bell, D. A., Blattner, F. R., Blumwald, E. et al. (2006a). Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution. Biol. Direct1,27.","DOI":"10.1186\/1745-6150-1-27"},{"key":"2021042621302646800_REF49","doi-asserted-by":"crossref","unstructured":"Novak, J. P., Miller, M. C., 3rd. and Bell, D. A.(2006b). Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples. Biol. Direct1, 18.","DOI":"10.1186\/1745-6150-1-18"},{"key":"2021042621302646800_REF50","unstructured":"Odgers, P. N. B. (1930). Some observations on the development of the ventral pancreas in man. J. Anat.65,1-7."},{"key":"2021042621302646800_REF51","doi-asserted-by":"crossref","unstructured":"Pearl, E. J. and Horb, M. E. (2008). Promoting ectopic pancreatic fates: pancreas development and future diabetes therapies. Clin. Genet.74,316-324.","DOI":"10.1111\/j.1399-0004.2008.01081.x"},{"key":"2021042621302646800_REF52","doi-asserted-by":"crossref","unstructured":"Pearl, E. J., Bilogan, C. K., Mukhi, S., Brown, D. D. and Horb,M. E. (2009). Xenopus pancreas development. Dev. Dyn. (in press).","DOI":"10.1002\/dvdy.21935"},{"key":"2021042621302646800_REF53","doi-asserted-by":"crossref","unstructured":"Quest, L. and Lombard, M. (2000). Pancreas divisum: opinio divisa. Gut47,317-319.","DOI":"10.1136\/gut.47.3.317"},{"key":"2021042621302646800_REF54","doi-asserted-by":"crossref","unstructured":"Shah, K. K., DeRidder, P. H., Schwab, R. E. and Alexander, T. J. (1987). CT diagnosis of dorsal pancreas agenesis. J. Comput. Assist. Tomogr.11,170-171.","DOI":"10.1097\/00004728-198701000-00038"},{"key":"2021042621302646800_REF55","doi-asserted-by":"crossref","unstructured":"Slack, J. M. (1995). Developmental biology of the pancreas. Development121,1569-1580.","DOI":"10.1242\/dev.121.6.1569"},{"key":"2021042621302646800_REF56","doi-asserted-by":"crossref","unstructured":"Suda, K., Mizuguchi, K. and Hoshino, A. (1981). Differences of the ventral and dorsal anlagen of pancreas after fusion. Acta Pathol. Jpn.31,583-589.","DOI":"10.1111\/j.1440-1827.1981.tb02755.x"},{"key":"2021042621302646800_REF57","doi-asserted-by":"crossref","unstructured":"Szala, S., Kasai, Y., Steplewski, Z., Rodeck, U., Koprowski, H. and Linnenbach, A. J. (1990). Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proc. Natl. Acad. Sci. USA87,6833-6837.","DOI":"10.1073\/pnas.87.17.6833"},{"key":"2021042621302646800_REF58","doi-asserted-by":"crossref","unstructured":"Tremblay, K. D. and Zaret, K. S. (2005). Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev. Biol.280, 87-99.","DOI":"10.1016\/j.ydbio.2005.01.003"},{"key":"2021042621302646800_REF59","doi-asserted-by":"crossref","unstructured":"Uchida, T., Takada, T., Ammori, B. J., Suda, K. and Takahashi,T. (1999). Three-dimensional reconstruction of the ventral and dorsal pancreas: a new insight into anatomy and embryonic development. J. Hepatobiliary Pancreat. Surg.6, 176-180.","DOI":"10.1007\/s005340050102"},{"key":"2021042621302646800_REF60","doi-asserted-by":"crossref","unstructured":"Wang, J. T., Lin, J. T., Chuang, C. N., Wang, S. M., Chuang, L. M., Chen, J. C., Huang, S. H., Chen, D. S. and Wang, T. H.(1990). Complete agenesis of the dorsal pancreas-a case report and review of the literature. Pancreas5, 493-497.","DOI":"10.1097\/00006676-199007000-00020"},{"key":"2021042621302646800_REF61","doi-asserted-by":"crossref","unstructured":"Watt, A. J., Zhao, R., Li, J. and Duncan, S. A.(2007). Development of the mammalian liver and ventral pancreas is dependent on GATA4. BMC Dev. Biol.7, 37.","DOI":"10.1186\/1471-213X-7-37"},{"key":"2021042621302646800_REF62","doi-asserted-by":"crossref","unstructured":"Wildling, R., Schnedl, W. J., Reisinger, E. C., Schreiber, F.,Lipp, R. W., Lederer, A. and Krejs, G. J. (1993). Agenesis of the dorsal pancreas in a woman with diabetes mellitus and in both of her sons. Gastroenterology104,1182-1186.","DOI":"10.1016\/0016-5085(93)90290-S"},{"key":"2021042621302646800_REF63","doi-asserted-by":"crossref","unstructured":"Wittingen, J. and Frey, C. F. (1974). Islet concentration in the head, body, tail and uncinate process of the pancreas. Ann. Surg.179,412-414.","DOI":"10.1097\/00000658-197404000-00005"},{"key":"2021042621302646800_REF64","doi-asserted-by":"crossref","unstructured":"Yi, S. Q., Akita, K., Ohta, T., Shimokawa, T., Tanaka, A., Ru,F., Nakatani, T., Isomura, G. and Tanaka, S. (2004). Cellular localization of endocrine cells in the adult pancreas of the house musk shrew,Suncus murinus: a comparative immunocytochemical study. Gen. Comp. Endocrinol.136,162-170.","DOI":"10.1016\/j.ygcen.2003.12.014"},{"key":"2021042621302646800_REF65","doi-asserted-by":"crossref","unstructured":"Zoller, M. (2009). Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer9,40-55.","DOI":"10.1038\/nrc2543"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/136\/11\/1791\/1542335\/1791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/136\/11\/1791\/1542335\/1791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T23:42:24Z","timestamp":1684971744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/136\/11\/1791\/65130\/The-tetraspanin-Tm4sf3-is-localized-to-the-ventral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,1]]},"references-count":65,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.032235","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6,1]]}}}