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Even adult dental tissues can form new teeth in response to either epithelial Apcloss-of-function or \u03b2-catenin activation, and the effect of Apcdeficiency is mediated by \u03b2-catenin. The formation of supernumerary teeth via Apc loss-of-function is non-cell-autonomous. A small number of Apc-deficient cells is sufficient to induce surrounding wild-type epithelial and mesenchymal cells to participate in the formation of new teeth. Strikingly, Msx1, which is necessary for endogenous tooth development, is dispensable for supernumerary tooth formation. In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt\/\u03b2-catenin signaling. These studies identify key mechanistic features responsible for supernumerary tooth formation.<\/jats:p>","DOI":"10.1242\/dev.033803","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T17:59:04Z","timestamp":1241805544000},"page":"1939-1949","source":"Crossref","is-referenced-by-count":195,"title":["Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood"],"prefix":"10.1242","volume":"136","author":[{"given":"Xiu-Ping","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Saadi","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kuraguchi","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Turbe-Doan","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resy","family":"Cavallesco","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Park","sequence":"additional","affiliation":[{"name":"Children's Hospital Informatics Program and Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemitsu","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy, School of Dentistry, Iwate Medical University,Iwate 020-8505, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Kucherlapati","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Maas","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042621304734300_REF1","doi-asserted-by":"crossref","unstructured":"Aberg, T., Wang, X. 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