{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:28:18Z","timestamp":1790843298860,"version":"4.1.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:p>The plant hormone auxin plays fundamental roles in vascular plants. Although exogenous auxin also stimulates developmental transitions and growth in non-vascular plants, the effects of manipulating endogenous auxin levels have thus far not been reported. Here, we have altered the levels and sites of auxin production and accumulation in the moss Physcomitrella patens by changing the expression level of homologues of the Arabidopsis SHI\/STY family proteins, which are positive regulators of auxin biosynthesis genes. Constitutive expression of PpSHI1 resulted in elevated auxin levels, increased and ectopic expression of the auxin response reporter GmGH3pro:GUS, and in an increased caulonema\/chloronema ratio, an effect also induced by exogenous auxin application. In addition, we observed premature ageing and necrosis in cells ectopically expressing PpSHI1. Knockout of either of the two PpSHI genes resulted in reduced auxin levels and auxin biosynthesis rates in leafy shoots, reduced internode elongation, delayed ageing, a decreased caulonema\/chloronema ratio and an increased number of axillary hairs, which constitute potential auxin biosynthesis sites. Some of the identified auxin functions appear to be analogous in vascular and non-vascular plants. Furthermore, the spatiotemporal expression of the PpSHI genes and GmGH3pro:GUS strongly overlap, suggesting that local auxin biosynthesis is important for the regulation of auxin peak formation in non-vascular plants.<\/jats:p>","DOI":"10.1242\/dev.039594","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T20:15:19Z","timestamp":1268338519000},"page":"1275-1284","source":"Crossref","is-referenced-by-count":93,"title":["Homologues of the\n                    <i>Arabidopsis thaliana SHI\/STY\/LRP1<\/i>\n                    genes control auxin biosynthesis and affect growth and development in the moss\n                    <i>Physcomitrella patens<\/i>"],"prefix":"10.1242","volume":"137","author":[{"given":"D. Magnus","family":"Eklund","sequence":"first","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Thelander","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Landberg","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"St\u00e5ldal","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."},{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R. A.","family":"Pederson","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, S-901 83 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Ljung","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, S-901 83 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Ronne","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences, Box 7080, S-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606463352900_R1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00425-002-0937-8","article-title":"Gradual shifts in sites of free-auxin production during leaf-primordium development and their role in vascular differentiation and leaf morphogenesis in Arabidopsis","volume":"216","author":"Aloni","year":"2003","journal-title":"Planta"},{"key":"2021042606463352900_R2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1105\/tpc.107.054676","article-title":"Requirement of B-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana","volume":"20","author":"Andersen","year":"2008","journal-title":"Plant Cell"},{"key":"2021042606463352900_R3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF00380118","article-title":"Analysis of gametophytic development in the moss, Physcomitrella patens, using auxin and cytokinin resistant mutants","volume":"144","author":"Ashton","year":"1979","journal-title":"Planta"},{"key":"2021042606463352900_R4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0092-8674(03)00924-3","article-title":"Local, efflux-dependent auxin gratiens as a common module for plant organ formation","volume":"115","author":"Benkova","year":"2003","journal-title":"Cell"},{"key":"2021042606463352900_R5","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00299-003-0646-1","article-title":"Use of an inducible reporter gene system for the analysis of auxin distribution in the moss Physcomitrella patens","volume":"21","author":"Bierfreund","year":"2003","journal-title":"Plant Cell Rep."},{"key":"2021042606463352900_R6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/bies.080146","article-title":"Local auxin production: a small contribution to a large field","volume":"3","author":"Chandler","year":"2009","journal-title":"BioEssays"},{"key":"2021042606463352900_R7","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gad.1415106","article-title":"Auxin biosynthesis by the YUCCA flavin monooxygenases controls the formation of floral organs and vascular tissues in Arabidopsis","volume":"20","author":"Cheng","year":"2006","journal-title":"Genes Dev."},{"key":"2021042606463352900_R8","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1105\/tpc.107.053009","article-title":"Auxin synthesized by the YUCCA flavin monooxygenases is essential for embryogenesis and leaf formation in Arabidopsis","volume":"19","author":"Cheng","year":"2007","journal-title":"Plant Cell"},{"key":"2021042606463352900_R9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1015242627321","article-title":"Evolutionary patterns in auxin action","volume":"49","author":"Cooke","year":"2002","journal-title":"Plant Mol. 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