{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:47:48Z","timestamp":1792140468932,"version":"4.4.0"},"reference-count":68,"publisher":"The Company of Biologists","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:p>In humans and mice, mutations in the Ret gene result in Hirschsprung's disease and renal defects. In the embryonic kidney, binding of Ret to its ligand, Gdnf, induces a program of epithelial cell remodeling that controls primary branch formation and branching morphogenesis within the kidney. Our previous studies showed that transcription factors belonging to the retinoic acid (RA) receptor family are crucial for controlling Ret expression in the ureteric bud; however, the mechanism by which retinoid-signaling acts has remained unclear. In the current study, we show that expression of a dominant-negative RA receptor in mouse ureteric bud cells abolishes Ret expression and Ret-dependent functions including ureteric bud formation and branching morphogenesis, indicating that RA-receptor signaling in ureteric bud cells is crucial for renal development. Conversely, we find that RA-receptor signaling in ureteric bud cells depends mainly on RA generated in nearby stromal cells by retinaldehyde dehydrogenase 2, an enzyme required for most fetal RA synthesis. Together, these studies suggest that renal development depends on paracrine RA signaling between stromal mesenchyme and ureteric bud cells that regulates Ret expression both during ureteric bud formation and within the developing collecting duct system.<\/jats:p>","DOI":"10.1242\/dev.040287","type":"journal-article","created":{"date-parts":[[2009,12,29]],"date-time":"2009-12-29T07:37:42Z","timestamp":1262072262000},"page":"283-292","source":"Crossref","is-referenced-by-count":173,"title":["Non-cell-autonomous retinoid signaling is crucial for renal development"],"prefix":"10.1242","volume":"137","author":[{"given":"Carolina","family":"Rosselot","sequence":"first","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Spraggon","sequence":"additional","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekatherina","family":"Batourina","sequence":"additional","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Riccio","sequence":"additional","affiliation":[{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Niederreither","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Dolle","sequence":"additional","affiliation":[{"name":"Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U. 596 de l'INSERM, Universite Louis Pasteur, CU de Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Duester","sequence":"additional","affiliation":[{"name":"Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U. 596 de l'INSERM, Universite Louis Pasteur, CU de Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Genetics, Reproduction and Development, GReD CNRS UMR 6247 Inserm U931, Universit\u00e9 d'Auvergne, Clermont-Ferrand, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Molotkov","sequence":"additional","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Mendelsohn","sequence":"additional","affiliation":[{"name":"Department of Urology, Columbia University, New York, New York, 10032USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606033594200_R1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/83792","article-title":"Vitamin A controls epithelial\/mesenchymal interactions through Ret expression.","volume":"27","author":"Batourina","year":"2001","journal-title":"Nat. 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