{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:42:24Z","timestamp":1784230944982,"version":"3.55.0"},"reference-count":42,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:p>The epididymis and efferent ducts play major roles in sperm maturation, transport, concentration and storage by reabsorbing water, ions and proteins produced from seminiferous tubules. Gpr48-null male mice demonstrate reproductive tract defects and infertility. In the present study, we found that estrogen receptor \u03b1 (ER\u03b1) was dramatically reduced in the epididymis and efferent ducts in Gpr48-null male mice. We further revealed that ER\u03b1 could be upregulated by Gpr48 activation via the cAMP\/PKA signaling pathway. Moreover, we identified a cAMP responsive element (Cre) motif located at \u22121307 to \u22121300 bp in the ER\u03b1 promoter that is able to interact with Cre binding protein (Creb). In conclusion, Gpr48 participates in the development of the male epididymis and efferent ducts through regulation of ER\u03b1 expression via the cAMP\/PKA signaling pathway.<\/jats:p>","DOI":"10.1242\/dev.040659","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T21:00:46Z","timestamp":1261170046000},"page":"151-157","source":"Crossref","is-referenced-by-count":45,"title":["G protein-coupled receptor 48 upregulates estrogen receptor \u03b1 expression via cAMP\/PKA signaling in the male reproductive tract"],"prefix":"10.1242","volume":"137","author":[{"given":"Xiao-Ying","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China"},{"name":"Division of Endocrinology and Metabolism, 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