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In addition, Notch\/Numb-mediated binary sibling fates underlie the production of PNs and local interneurons from common precursors in the lAL lineage. Furthermore, Numb is needed in the lateral but not adPN or vPN lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. These lineage-specific outputs of Notch\/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.<\/jats:p>","DOI":"10.1242\/dev.041699","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T21:00:46Z","timestamp":1261170046000},"page":"43-51","source":"Crossref","is-referenced-by-count":70,"title":["Lineage-specific effects of Notch\/Numb signaling in post-embryonic development of the <i>Drosophila<\/i> brain"],"prefix":"10.1242","volume":"137","author":[{"given":"Suewei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-Lin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang-Hsiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Chihara","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Luo","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"},{"name":"Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612385574000_R1","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1101\/gad.9.21.2609","article-title":"Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity","volume":"9","author":"Bailey","year":"1995","journal-title":"Genes Dev."},{"key":"2021042612385574000_R2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.conb.2003.12.002","article-title":"Asymmetric localization and function of cell-fate determinants: a fly's view","volume":"14","author":"Bardin","year":"2004","journal-title":"Curr. 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