{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:52:13Z","timestamp":1792205533051,"version":"4.4.0"},"reference-count":28,"publisher":"The Company of Biologists","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:p>In bilateria, positioning and looping of visceral organs requires proper left-right (L\/R) asymmetry establishment. Recent work in Drosophila has identified a novel situs inversus gene encoding the unconventional type ID myosin (MyoID). In myoID mutant flies, the L\/R axis is inverted, causing reversed looping of organs, such as the gut, spermiduct and genitalia. We have previously shown that MyoID interacts physically with \u03b2-Catenin, suggesting a role of the adherens junction in Drosophila L\/R asymmetry. Here, we show that DE-Cadherin co-immunoprecipitates with MyoID and is required for MyoID L\/R activity. We further demonstrate that MyoIC, a closely related unconventional type I myosin, can antagonize MyoID L\/R activity by preventing its binding to adherens junction components, both in vitro and in vivo. Interestingly, DE-Cadherin inhibits MyoIC, providing a protective mechanism to MyoID function. Conditional genetic experiments indicate that DE-Cadherin, MyoIC and MyoID show temporal synchronicity for their function in L\/R asymmetry. These data suggest that following MyoID recruitment by \u03b2-Catenin at the adherens junction, DE-Cadherin has a twofold effect on Drosophila L\/R asymmetry by promoting MyoID activity and repressing that of MyoIC. Interestingly, the product of the vertebrate situs inversus gene inversin also physically interacts with \u03b2-Catenin, suggesting that the adherens junction might serve as a conserved platform for determinants to establish L\/R asymmetry both in vertebrates and invertebrates.<\/jats:p>","DOI":"10.1242\/dev.047589","type":"journal-article","created":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T00:39:38Z","timestamp":1333672778000},"page":"1874-1884","source":"Crossref","is-referenced-by-count":73,"title":["DE-Cadherin regulates unconventional Myosin ID and Myosin IC in <i>Drosophila<\/i> left-right asymmetry establishment"],"prefix":"10.1242","volume":"139","author":[{"given":"Astrid G.","family":"Petzoldt","sequence":"first","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."},{"name":"Center for Biological Systems Analysis, University of Freiburg; Habsburger Str. 49, 78104 Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Coutelis","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"G\u00e9minard","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Sp\u00e9der","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."},{"name":"The Gurdon Institute; University of Cambridge; Tennis Court Road, Cambridge CB2 1QN, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Suzanne","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."},{"name":"Laboratory of Cellular and Molecular Biology of Cell Proliferation (LBCMCP) UMR5088, University Paul Sabatier, 31062 Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Cerezo","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Noselli","sequence":"additional","affiliation":[{"name":"Institute of Biology Valrose, University of Nice Sophia-Antipolis, UMR7277-CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606163332300_R1","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.00460","article-title":"The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila","volume":"130","author":"\u00c1d\u00e1m","year":"2003","journal-title":"Development"},{"key":"2021042606163332300_R2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ajmg.1219","article-title":"Clinical aspects of defects in the determination of laterality","volume":"101","author":"Aylsworth","year":"2001","journal-title":"Am. 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