{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:04:24Z","timestamp":1768831464531,"version":"3.49.0"},"reference-count":89,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:p>The embryonic ocular neuroepithilium generates a myriad of cell types, including the neuroretina, the pigmented epithelium, the ciliary and iris epithelia, and the iris smooth muscles. As in other regions of the developing nervous system, the generation of these various cell types requires a coordinated sequence of patterning, specification and differentiation events. We investigated the roles of microRNAs (miRNAs) in the development of optic cup (OC)-derived structures. We inactivated Dicer1, a key mediator of miRNA biosynthesis, within the OC in overlapping yet distinct spatiotemporal patterns. Ablation of Dicer1 in the inner layer of the OC resulted in patterning alteration, particularly at the most distal margins. Following loss of Dicer1, this region generated a cryptic population of cells with a mixed phenotype of neuronal and ciliary body (CB) progenitors. Notably, inactivation of Dicer1 in the retinal progenitors further resulted in abrogated neurogenesis, with prolongation of ganglion cell birth and arrested differentiation of other neuronal subtypes, including amacrine and photoreceptor cells. These alterations were accompanied by changes in the expression of Notch and Hedgehog signaling components, indicating the sensitivity of the pathways to miRNA activity. Moreover, this study revealed the requirement of miRNAs for morphogenesis of the iris and for the regulation of CB cell type proliferation and differentiation. Together, analysis of the three genetic models revealed novel, stage-dependent roles for miRNAs in the development of the ocular sub-organs, which are all essential for normal vision.<\/jats:p>","DOI":"10.1242\/dev.053637","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T12:34:25Z","timestamp":1291725265000},"page":"127-138","source":"Crossref","is-referenced-by-count":56,"title":["Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium"],"prefix":"10.1242","volume":"138","author":[{"given":"Noa","family":"Davis","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Mor","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Ashery-Padan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042606505785900_R1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/bbrc.2000.2473","article-title":"Identification of neural progenitors in the adult mammalian eye","volume":"270","author":"Ahmad","year":"2000","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2021042606505785900_R2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"key":"2021042606505785900_R3","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1523\/JNEUROSCI.17-04-01425.1997","article-title":"The expression and function of Notch pathway genes in the developing rat eye","volume":"17","author":"Bao","year":"1997","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat. Genet"},{"key":"2021042606505785900_R5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-0749.2006.00318.x","article-title":"The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye","volume":"19","author":"Bharti","year":"2006","journal-title":"Pigment Cell Res"},{"key":"2021042606505785900_R6","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1242\/jcs.03202","article-title":"Connexin43 is required for production of the aqueous humor in the murine eye","volume":"119","author":"Calera","year":"2006","journal-title":"J. Cell Sci"},{"key":"2021042606505785900_R7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/exer.2002.1187","article-title":"Molecular profiling and cellular localization of connexin isoforms in the rat ciliary epithelium","volume":"75","author":"Coffey","year":"2002","journal-title":"Exp. Eye Res"},{"key":"2021042606505785900_R8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bies.20009","article-title":"Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases","volume":"26","author":"Cvekl","year":"2004","journal-title":"BioEssays"},{"key":"2021042606505785900_R9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2008.06.058","article-title":"Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells","volume":"1228","author":"Dakubo","year":"2008","journal-title":"Brain Res"},{"key":"2021042606505785900_R10","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1523\/JNEUROSCI.0828-08.2008","article-title":"Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina","volume":"28","author":"Damiani","year":"2008","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2007.03.043","article-title":"Iris development in vertebrates; genetic and molecular considerations","volume":"1192","author":"Davis-Silberman","year":"2008","journal-title":"Brain Res"},{"key":"2021042606505785900_R12","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/hmg\/ddi231","article-title":"Genetic dissection of Pax6 dosage requirements in the developing mouse eye","volume":"14","author":"Davis-Silberman","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"2021042606505785900_R13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ydbio.2009.06.023","article-title":"Pax6 dosage requirements in iris and ciliary body differentiation","volume":"333","author":"Davis","year":"2009","journal-title":"Dev. Biol"},{"key":"2021042606505785900_R14","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1523\/JNEUROSCI.4815-07.2008","article-title":"Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus","volume":"28","author":"Davis","year":"2008","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R15","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1387\/ijdb.082646sd","article-title":"Dicer inactivation causes heterochronic retinogenesis in Xenopus laevis","volume":"52","author":"Decembrini","year":"2008","journal-title":"Int. J. Dev. Biol"},{"key":"2021042606505785900_R16","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1242\/dev.127.16.3593","article-title":"p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina","volume":"127","author":"Dyer","year":"2000","journal-title":"Development"},{"key":"2021042606505785900_R17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.conb.2006.01.001","article-title":"Secreted inducers in vertebrate eye development: more functions for old morphogens","volume":"16","author":"Esteve","year":"2006","journal-title":"Curr. Opin. Neurobiol"},{"key":"2021042606505785900_R18","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1242\/dev.02664","article-title":"Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina","volume":"133","author":"Feng","year":"2006","journal-title":"Development"},{"key":"2021042606505785900_R19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/dbio.2000.9640","article-title":"Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens","volume":"220","author":"Fischer","year":"2000","journal-title":"Dev. Biol"},{"key":"2021042606505785900_R20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000048710","article-title":"Transdifferentiation of pigmented epithelial cells: a source of retinal stem cells?","volume":"23","author":"Fischer","year":"2001","journal-title":"Dev. Neurosci"},{"key":"2021042606505785900_R21","doi-asserted-by":"crossref","first-page":"7915","DOI":"10.1073\/pnas.0812446106","article-title":"MicroRNAs are essential for development and function of inner ear hair cells in vertebrates","volume":"106","author":"Friedman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res"},{"key":"2021042606505785900_R23","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1242\/dev.02598","article-title":"Ptf1a determines horizontal and amacrine cell fates during mouse retinal development","volume":"133","author":"Fujitani","year":"2006","journal-title":"Development"},{"key":"2021042606505785900_R24","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/dvdy.20658","article-title":"Complementary Gli activity mediates early patterning of the mouse visual system","volume":"235","author":"Furimsky","year":"2006","journal-title":"Dev. Dyn"},{"key":"2021042606505785900_R25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)80439-0","article-title":"Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation","volume":"91","author":"Furukawa","year":"1997","journal-title":"Cell"},{"key":"2021042606505785900_R26","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1523\/JNEUROSCI.4982-09.2010","article-title":"Dicer is required for the transition from early to late progenitor state in the developing mouse retina","volume":"30","author":"Georgi","year":"2010","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1122689","article-title":"Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs","volume":"312","author":"Giraldez","year":"2006","journal-title":"Science"},{"key":"2021042606505785900_R28","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1387\/ijdb.041865dg","article-title":"Anterior segment development relevant to glaucoma","volume":"48","author":"Gould","year":"2004","journal-title":"Int. J. Dev. Biol"},{"key":"2021042606505785900_R29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1520-6408(1996)18:3<181::AID-DVG1>3.0.CO;2-5","article-title":"Genetic aspects of embryonic eye development in vertebrates","volume":"18","author":"Graw","year":"1996","journal-title":"Dev. Genet"},{"key":"2021042606505785900_R30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","article-title":"Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing","volume":"106","author":"Grishok","year":"2001","journal-title":"Cell"},{"key":"2021042606505785900_R31","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1167\/iovs.09-4657","article-title":"MicroRNA profile of the developing mouse retina","volume":"51","author":"Hackler","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"2021042606505785900_R32","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1167\/iovs.04-1185","article-title":"Basement membrane-dependent survival of retinal ganglion cells","volume":"46","author":"Halfter","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"2021042606505785900_R33","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/eye.2008.19","article-title":"Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body","volume":"22","author":"Halfter","year":"2008","journal-title":"Eye"},{"key":"2021042606505785900_R34","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1073\/pnas.0504834102","article-title":"The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb","volume":"102","author":"Harfe","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R35","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1073\/pnas.0510839103","article-title":"Dicer function is essential for lung epithelium morphogenesis","volume":"103","author":"Harris","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R36","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1681\/ASN.2008020233","article-title":"Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease","volume":"19","author":"Harvey","year":"2008","journal-title":"J. Am. Soc. Nephrol"},{"key":"2021042606505785900_R37","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1681\/ASN.2008020162","article-title":"Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury","volume":"19","author":"Ho","year":"2008","journal-title":"J. Am. Soc. Nephrol"},{"key":"2021042606505785900_R38","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/ng1803","article-title":"Canalization of development by microRNAs","volume":"38","author":"Hornstein","year":"2006","journal-title":"Nat. Genet"},{"key":"2021042606505785900_R39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1242\/dev.01571","article-title":"Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity","volume":"132","author":"Horsford","year":"2005","journal-title":"Development"},{"key":"2021042606505785900_R40","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1242\/dev.01697","article-title":"Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development","volume":"132","author":"Inagaki","year":"2005","journal-title":"Development"},{"key":"2021042606505785900_R41","doi-asserted-by":"crossref","first-page":"18998","DOI":"10.1073\/pnas.0608155103","article-title":"Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property","volume":"103","author":"Jadhav","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R42","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1242\/dev.02245","article-title":"Notch 1 inhibits photoreceptor production in the developing mammalian retina","volume":"133","author":"Jadhav","year":"2006","journal-title":"Development"},{"key":"2021042606505785900_R43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.cr.7290016","article-title":"The Notch-Hes pathway in mammalian neural development","volume":"9","author":"Kageyama","year":"1999","journal-title":"Cell Res"},{"key":"2021042606505785900_R44","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.1248505","article-title":"Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing","volume":"19","author":"Kanellopoulou","year":"2005","journal-title":"Genes Dev"},{"key":"2021042606505785900_R45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1167\/iovs.06-0866","article-title":"Identification and characterization of microRNAs expressed in the mouse eye","volume":"48","author":"Karali","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"2021042606505785900_R46","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00441-005-0130-z","article-title":"Differential expression of caveolin-3 in mouse smooth muscle cells in vivo","volume":"324","author":"Kogo","year":"2006","journal-title":"Cell Tissue Res"},{"key":"2021042606505785900_R47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijdevneu.2009.04.004","article-title":"Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina","volume":"27","author":"Larsen","year":"2009","journal-title":"Int. J. Dev. Neurosci"},{"key":"2021042606505785900_R48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/dbio.2001.0280","article-title":"Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant","volume":"236","author":"Lee","year":"2001","journal-title":"Dev. Biol"},{"key":"2021042606505785900_R49","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.1065329","article-title":"An extensive class of small RNAs in Caenorhabditis elegans","volume":"294","author":"Lee","year":"2001","journal-title":"Science"},{"key":"2021042606505785900_R50","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2004.08.041","article-title":"Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors","volume":"43","author":"Li","year":"2004","journal-title":"Neuron"},{"key":"2021042606505785900_R51","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1002\/dvdy.22056","article-title":"Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development","volume":"238","author":"Li","year":"2009","journal-title":"Dev. Dyn"},{"key":"2021042606505785900_R52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2007.04.052","article-title":"Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling","volume":"308","author":"Liu","year":"2007","journal-title":"Dev. Biol"},{"key":"2021042606505785900_R53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/dbio.1999.9209","article-title":"Z\/AP, a double reporter for cre-mediated recombination","volume":"208","author":"Lobe","year":"1999","journal-title":"Dev. Biol"},{"key":"2021042606505785900_R54","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1100\/tsw.2006.313","article-title":"MicroRNAs in development","volume":"6","author":"Maatouk","year":"2006","journal-title":"ScientificWorldJournal"},{"key":"2021042606505785900_R55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00295-1","article-title":"Pax6 is required for the multipotent state of retinal progenitor cells","volume":"105","author":"Marquardt","year":"2001","journal-title":"Cell"},{"key":"2021042606505785900_R56","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1242\/dev.128.11.2019","article-title":"Otx genes are required for tissue specification in the developing eye","volume":"128","author":"Martinez-Morales","year":"2001","journal-title":"Development"},{"key":"2021042606505785900_R57","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature08725","article-title":"Opposing microRNA families regulate self-renewal in mouse embryonic stem cells","volume":"463","author":"Melton","year":"2010","journal-title":"Nature"},{"key":"2021042606505785900_R58","first-page":"717","article-title":"[Multipotent and stem cells in the developing, definitive, and regenerating vertebrate eye]","author":"Mitashov","year":"2001","journal-title":"Izv. Akad. Nauk. Ser. Biol"},{"key":"2021042606505785900_R59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.126.1.23","article-title":"NeuroD regulates multiple functions in the developing neural retina in rodent","volume":"126","author":"Morrow","year":"1999","journal-title":"Development"},{"key":"2021042606505785900_R60","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1387\/ijdb.041870am","article-title":"Retinal stem cells and regeneration","volume":"48","author":"Moshiri","year":"2004","journal-title":"Int. J. Dev. Biol"},{"key":"2021042606505785900_R61","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1073\/pnas.0802627105","article-title":"Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2","volume":"105","author":"Mu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/dvdy.20302","article-title":"Proliferation and cell shape changes during ciliary body morphogenesis in the mouse","volume":"233","author":"Napier","year":"2005","journal-title":"Dev. Dyn"},{"key":"2021042606505785900_R63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/cr.1998.2","article-title":"The role of the hedgehog\/patched signaling pathway in epithelial stem cell proliferation: from fly to human","volume":"8","author":"Parisi","year":"1998","journal-title":"Cell Res"},{"key":"2021042606505785900_R64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"2021042606505785900_R65","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"2021042606505785900_R66","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1523\/JNEUROSCI.3382-09.2009","article-title":"Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina","volume":"29","author":"Riesenberg","year":"2009","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R67","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1242\/dev.01300","article-title":"Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10","volume":"131","author":"Rowan","year":"2004","journal-title":"Development"},{"key":"2021042606505785900_R68","first-page":"1175","article-title":"MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity","volume":"12","author":"Ryan","year":"2006","journal-title":"Mol. Vis"},{"key":"2021042606505785900_R69","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1073\/pnas.0510631103","article-title":"Essential role of retinoblastoma protein in mammalian hair cell development and hearing","volume":"103","author":"Sage","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606505785900_R70","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1523\/JNEUROSCI.0289-09.2009","article-title":"Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina","volume":"29","author":"Sakagami","year":"2009","journal-title":"J. Neurosci"},{"key":"2021042606505785900_R71","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach","year":"2008","journal-title":"Nature"},{"key":"2021042606505785900_R72","volume-title":"Systematic Evaluation of the Mouse Eye","author":"Smith","year":"2002"},{"key":"2021042606505785900_R73","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1242\/dev.01298","article-title":"The hedgehog pathway is a modulator of retina regeneration","volume":"131","author":"Spence","year":"2004","journal-title":"Development"},{"key":"2021042606505785900_R74","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev"},{"key":"2021042606505785900_R75","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1126\/science.287.5460.2032","article-title":"Retinal stem cells in the adult mammalian eye","volume":"287","author":"Tropepe","year":"2000","journal-title":"Science"},{"key":"2021042606505785900_R76","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","article-title":"Pax-6, a murine paired box gene, is expressed in the developing CNS","volume":"113","author":"Walther","year":"1991","journal-title":"Development"},{"key":"2021042606505785900_R77","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1096\/fj.08-125856","article-title":"MicroRNA-204\/211 alters epithelial physiology","volume":"24","author":"Wang","year":"2010","journal-title":"FASEB J."},{"key":"2021042606505785900_R78","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1101\/gad.855301","article-title":"Requirement for math5 in the development of retinal ganglion cells","volume":"15","author":"Wang","year":"2001","journal-title":"Genes Dev"},{"key":"2021042606505785900_R79","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1242\/dev.02096","article-title":"Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina","volume":"132","author":"Wang","year":"2005","journal-title":"Development"},{"key":"2021042606505785900_R80","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ng1969","article-title":"DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal","volume":"39","author":"Wang","year":"2007","journal-title":"Nat. Genet"},{"key":"2021042606505785900_R81","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"2021042606505785900_R82","doi-asserted-by":"crossref","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J. Biol. Chem"},{"key":"2021042606505785900_R83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcdb.2003.09.004","article-title":"Roles of cell-extrinsic growth factors in vertebrate eye pattern formation and retinogenesis","volume":"15","author":"Yang","year":"2004","journal-title":"Semin. Cell Dev. Biol"},{"key":"2021042606505785900_R84","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1242\/dev.02311","article-title":"Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina","volume":"133","author":"Yaron","year":"2006","journal-title":"Development"},{"key":"2021042606505785900_R85","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature06642","article-title":"A skin microRNA promotes differentiation by repressing `stemness'","volume":"452","author":"Yi","year":"2008","journal-title":"Nature"},{"key":"2021042606505785900_R86","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ar.1092120215","article-title":"Cell differentiation in the retina of the mouse","volume":"212","author":"Young","year":"1985","journal-title":"Anat. Rec"},{"key":"2021042606505785900_R87","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mcn.2006.05.002","article-title":"Direct and indirect effects of hedgehog pathway activation in the mammalian retina","volume":"32","author":"Yu","year":"2006","journal-title":"Mol. Cell. Neurosci"},{"key":"2021042606505785900_R88","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1242\/dev.128.6.943","article-title":"Regulation of retinal ganglion cell production by Sonic hedgehog","volume":"128","author":"Zhang","year":"2001","journal-title":"Development"},{"key":"2021042606505785900_R89","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/dev.129.19.4435","article-title":"BMP signaling is required for development of the ciliary body","volume":"129","author":"Zhao","year":"2002","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/1\/127\/1199073\/127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/1\/127\/1199073\/127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T09:23:33Z","timestamp":1619429013000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/138\/1\/127\/44344\/Roles-for-Dicer1-in-the-patterning-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.053637","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,1]]}}}