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This cell fate conversion is associated with a striking increase in PAX6, and genetically ablating SOX2 on a Pax6-haploinsufficient background partially rescues the Sox2-mutant phenotype. Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina.<\/jats:p>","DOI":"10.1242\/dev.055178","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T12:27:55Z","timestamp":1294144075000},"page":"443-454","source":"Crossref","is-referenced-by-count":103,"title":["Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6"],"prefix":"10.1242","volume":"138","author":[{"given":"Danielle","family":"Matsushima","sequence":"first","affiliation":[{"name":"UNC Neuroscience Center, University of North Carolina at Chapel Hill, 27599 NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Heavner","sequence":"additional","affiliation":[{"name":"UNC Genetics Curriculum, University of North Carolina at Chapel Hill, 27599 NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa H.","family":"Pevny","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, University of North Carolina at Chapel Hill, 27599 NC, USA."},{"name":"Department of Genetics, University of North Carolina at Chapel Hill, 27599 NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607103168700_R1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1096-9861(19970310)379:2<171::AID-CNE1>3.0.CO;2-0","article-title":"Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway","volume":"379","author":"Anchan","year":"1997","journal-title":"J. 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