{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:26:14Z","timestamp":1790133974543,"version":"4.0.1"},"reference-count":59,"publisher":"The Company of Biologists","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:p>Defects in the development or maintenance of tubule diameter correlate with polycystic kidney disease. Here, we report that absence of the cadherin regulator p120 catenin (p120ctn) from the renal mesenchyme prior to tubule formation leads to decreased cadherin levels with abnormal morphologies of early tubule structures and developing glomeruli. In addition, mutant mice develop cystic kidney disease, with markedly increased tubule diameter and cellular proliferation, and detached luminal cells only in proximal tubules. The p120ctn homolog Arvcf is specifically absent from embryonic proximal tubules, consistent with the specificity of the proximal tubular phenotype. p120ctn knockdown in renal epithelial cells in 3D culture results in a similar cystic phenotype with reduced levels of E-cadherin and active RhoA. We find that E-cadherin knockdown, but not RhoA inhibition, phenocopies p120ctn knockdown. Taken together, our data show that p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins.<\/jats:p>","DOI":"10.1242\/dev.056564","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T07:33:05Z","timestamp":1303803185000},"page":"2099-2109","source":"Crossref","is-referenced-by-count":60,"title":["p120 catenin is required for normal renal tubulogenesis and glomerulogenesis"],"prefix":"10.1242","volume":"138","author":[{"given":"Denise K.","family":"Marciano","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, CA 94158, USA"},{"name":"Department of Physiology, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Brakeman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA 94158, USA"},{"name":"Department of Anatomy, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Zong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Spivak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA 94158, USA"},{"name":"Department of Anatomy, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Eastburn","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Gerard M.","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Joint Research Division Vascular Biology, Medical Faculty Mannheim, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E.","family":"Mostov","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis F.","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of California, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606531495300_R1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1242\/jcs.115.7.1391","article-title":"Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells","volume":"115","author":"Aho","year":"2002","journal-title":"J. Cell Sci."},{"key":"2021042606531495300_R2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/35023588","article-title":"Inhibition of RhoA by p120 catenin","volume":"2","author":"Anastasiadis","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"2021042606531495300_R3","doi-asserted-by":"crossref","first-page":"10882","DOI":"10.1073\/pnas.0702731104","article-title":"p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin","volume":"104","author":"Boguslavsky","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606531495300_R4","doi-asserted-by":"crossref","first-page":"F564","DOI":"10.1152\/ajprenal.90328.2008","article-title":"Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis","volume":"296","author":"Brakeman","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021042606531495300_R5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ncb2106","article-title":"A molecular network for de novo generation of the apical surface and lumen","volume":"12","author":"Bryant","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2021042606531495300_R6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1091\/mbc.e06-05-0471","article-title":"Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells","volume":"18","author":"Capaldo","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2021042606531495300_R7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1242\/dev.02773","article-title":"Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron","volume":"134","author":"Cheng","year":"2007","journal-title":"Development"},{"key":"2021042606531495300_R8","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1091\/mbc.e08-07-0735","article-title":"p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism","volume":"20","author":"Chiasson","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"2021042606531495300_R9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/B978-012722441-1\/50016-6","article-title":"Formation and development of nephrons","volume-title":"The Kidney: From Normal Development to Congenital Disease","author":"Cho","year":"2003"},{"key":"2021042606531495300_R10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1242\/dev.125.5.803","article-title":"Differential expression and function of cadherin-6 during renal epithelium development","volume":"125","author":"Cho","year":"1998","journal-title":"Development"},{"key":"2021042606531495300_R11","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/jcs.01298","article-title":"p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus","volume":"117","author":"Ciesiolka","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021042606531495300_R12","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1128\/MCB.22.5.1474-1487.2002","article-title":"Genetic dissection of cadherin function during nephrogenesis","volume":"22","author":"Dahl","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2021042606531495300_R13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.devcel.2005.12.004","article-title":"Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland","volume":"10","author":"Davis","year":"2006","journal-title":"Dev. Cell"},{"key":"2021042606531495300_R14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.200307111","article-title":"A core function for p120-catenin in cadherin turnover","volume":"163","author":"Davis","year":"2003","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R15","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1242\/dev.034876","article-title":"Advances in early kidney specification, development and patterning","volume":"136","author":"Dressler","year":"2009","journal-title":"Development"},{"key":"2021042606531495300_R16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0012-1606(02)00016-7","article-title":"Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants","volume":"253","author":"Duguay","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042606531495300_R17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2006.05.018","article-title":"p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins","volume":"51","author":"Elia","year":"2006","journal-title":"Neuron"},{"key":"2021042606531495300_R18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.200307109","article-title":"Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac","volume":"165","author":"Fang","year":"2004","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s004180000175","article-title":"The catenin, p120ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissues","volume":"114","author":"Golenhofen","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"2021042606531495300_R20","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1681\/ASN.V971234","article-title":"Involvement of R-cadherin in the early stage of glomerulogenesis","volume":"9","author":"Goto","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042606531495300_R21","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1242\/dev.01944","article-title":"FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons","volume":"132","author":"Grieshammer","year":"2005","journal-title":"Development"},{"key":"2021042606531495300_R22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm1699","article-title":"Regulation of cadherin-mediated adhesion in morphogenesis","volume":"6","author":"Gumbiner","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042606531495300_R23","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1101\/gad.1486806","article-title":"Cadherins in development: cell adhesion, sorting, and tissue morphogenesis","volume":"20","author":"Halbleib","year":"2006","journal-title":"Genes Dev."},{"key":"2021042606531495300_R24","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/hmg\/ddp190","article-title":"Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways","volume":"18","author":"Happe","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2021042606531495300_R25","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2009010014","article-title":"2008 Homer W. Smith award: insights into the pathogenesis of polycystic kidney disease from gene discovery","volume":"20","author":"Harris","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042606531495300_R26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1242\/dev.128.4.561","article-title":"Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development","volume":"128","author":"Inoue","year":"2001","journal-title":"Development"},{"key":"2021042606531495300_R27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ng.400","article-title":"Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis","volume":"41","author":"Karner","year":"2009","journal-title":"Nat. Genet."},{"key":"2021042606531495300_R28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/geno.1998.5325","article-title":"Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms","volume":"50","author":"Keirsebilck","year":"1998","journal-title":"Genomics"},{"key":"2021042606531495300_R29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<162::AID-GENE21>3.0.CO;2-R","article-title":"Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice","volume":"26","author":"Li","year":"2000","journal-title":"Genesis"},{"key":"2021042606531495300_R30","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.yexcr.2008.12.016","article-title":"P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells","volume":"315","author":"Liu","year":"2009","journal-title":"Exp. Cell Res."},{"key":"2021042606531495300_R31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/dbio.2000.9738","article-title":"Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons","volume":"223","author":"Mah","year":"2000","journal-title":"Dev. Biol."},{"key":"2021042606531495300_R32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbamcr.2006.06.009","article-title":"Developmental functions of the P120-catenin sub-family","volume":"1773","author":"McCrea","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042606531495300_R33","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1432-0436.2006.00102.x","article-title":"Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development","volume":"74","author":"Meyer","year":"2006","journal-title":"Differentiation"},{"key":"2021042606531495300_R34","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1111\/j.1523-1755.2005.00655.x","article-title":"A role for microfilament-based contraction in branching morphogenesis of the ureteric bud","volume":"68","author":"Michael","year":"2005","journal-title":"Kidney Int."},{"key":"2021042606531495300_R35","first-page":"2633","article-title":"Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines","volume":"56","author":"Mo","year":"1996","journal-title":"Cancer Res."},{"key":"2021042606531495300_R36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1177\/002215540104901202","article-title":"Tissue distribution and cell type-specific expression of p120ctn isoforms","volume":"49","author":"Montonen","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"2021042606531495300_R37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1083\/jcb.150.3.567","article-title":"p120 catenin regulates the actin cytoskeleton via Rho family GTPases","volume":"150","author":"Noren","year":"2000","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/CIRCRESAHA.109.207753","article-title":"p120-catenin is required for mouse vascular development","volume":"106","author":"Oas","year":"2010","journal-title":"Circ. Res."},{"key":"2021042606531495300_R39","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1242\/jcs.01004","article-title":"The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation","volume":"117","author":"Ohkubo","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021042606531495300_R40","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/dev.006155","article-title":"Wnt\/beta-catenin signaling regulates nephron induction during mouse kidney development","volume":"134","author":"Park","year":"2007","journal-title":"Development"},{"key":"2021042606531495300_R41","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/hmg\/ddn045","article-title":"Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia","volume":"17","author":"Patel","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2021042606531495300_R42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.11.043","article-title":"p120-catenin mediates inflammatory responses in the skin","volume":"124","author":"Perez-Moreno","year":"2006","journal-title":"Cell"},{"key":"2021042606531495300_R43","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1091\/mbc.e06-04-0348","article-title":"E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions","volume":"18","author":"Perrais","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2021042606531495300_R44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(02)00695-5","article-title":"Regulation of motor neuron pool sorting by differential expression of type II cadherins","volume":"109","author":"Price","year":"2002","journal-title":"Cell"},{"key":"2021042606531495300_R45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbamcr.2006.09.019","article-title":"p120-catenin: past and present","volume":"1773","author":"Reynolds","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042606531495300_R46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00849241","article-title":"Early organogenesis of the kidney","volume":"1","author":"Saxen","year":"1987","journal-title":"Pediatr. Nephrol."},{"key":"2021042606531495300_R47","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ki.2008.322","article-title":"WNT\/beta-catenin signaling in nephron progenitors and their epithelial progeny","volume":"74","author":"Schmidt-Ott","year":"2008","journal-title":"Kidney Int."},{"key":"2021042606531495300_R48","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1172\/JCI41414","article-title":"p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice","volume":"120","author":"Smalley-Freed","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2021042606531495300_R49","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1083\/jcb.200805113","article-title":"p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression","volume":"183","author":"Soto","year":"2008","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<241::AID-DVG7>3.0.CO;2-R","article-title":"Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis","volume":"24","author":"Srinivas","year":"1999","journal-title":"Dev. Genet."},{"key":"2021042606531495300_R51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00429-002-0298-x","article-title":"Localization of intercellular adherens junction protein p120 catenin during podocyte differentiation","volume":"206","author":"Usui","year":"2003","journal-title":"Anat. Embryol. (Berl.)"},{"key":"2021042606531495300_R52","doi-asserted-by":"crossref","first-page":"17901","DOI":"10.1074\/jbc.M111635200","article-title":"Wnt signaling controls the phosphorylation status of beta-catenin","volume":"277","author":"van Noort","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021042606531495300_R53","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00418-008-0456-1","article-title":"Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney","volume":"130","author":"Walter","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"2021042606531495300_R54","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cell.2006.09.046","article-title":"p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho","volume":"127","author":"Wildenberg","year":"2006","journal-title":"Cell"},{"key":"2021042606531495300_R55","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.200306001","article-title":"Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells","volume":"163","author":"Xiao","year":"2003","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R56","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1091\/mbc.e05-05-0440","article-title":"p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin","volume":"16","author":"Xiao","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"2021042606531495300_R57","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1083\/jcb.200605022","article-title":"p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness","volume":"174","author":"Yanagisawa","year":"2006","journal-title":"J. Cell Biol."},{"key":"2021042606531495300_R58","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M801192200","article-title":"A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease","volume":"283","author":"Yanagisawa","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021042606531495300_R59","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1242\/dev.129.22.5301","article-title":"Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney","volume":"129","author":"Yu","year":"2002","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/10\/2099\/1475639\/2099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/10\/2099\/1475639\/2099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T01:34:58Z","timestamp":1637544898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/138\/10\/2099\/44399\/p120-catenin-is-required-for-normal-renal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,15]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,5,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.056564","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10912956.12087054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10912956.15089058","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10912956.11841054","asserted-by":"object"}]},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,15]]}}}