{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:44:07Z","timestamp":1791355447116,"version":"4.3.1"},"reference-count":75,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>Drosophila neuroblasts have served as a model to understand how the balance of stem cell self-renewal versus differentiation is achieved. Drosophila Numb protein regulates this process through its preferential segregation into the differentiating daughter cell. How Numb restricts the proliferation and self-renewal potentials of the recipient cell remains enigmatic. Here, we show that phosphorylation at conserved sites regulates the tumor suppressor activity of Numb. Enforced expression of a phospho-mimetic form of Numb (Numb-TS4D) or genetic manipulation that boosts phospho-Numb levels, attenuates endogenous Numb activity and causes ectopic neuroblast formation (ENF). This effect on neuroblast homeostasis occurs only in the type II neuroblast lineage. We identify Dronc caspase as a novel binding partner of Numb, and demonstrate that overexpression of Dronc suppresses the effects of Numb-TS4D in a non-apoptotic and possibly non-catalytic manner. Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis.<\/jats:p>","DOI":"10.1242\/dev.058347","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T13:23:54Z","timestamp":1305033834000},"page":"2185-2196","source":"Crossref","is-referenced-by-count":34,"title":["Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"138","author":[{"given":"Yingshi","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Petritsch","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Texas M. 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Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Jan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh Nung","family":"Jan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606522804300_R1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.mod.2005.08.004","article-title":"Regulation of post-embryonic neuroblasts by Drosophila Grainyhead","volume":"122","author":"Almeida","year":"2005","journal-title":"Mech. 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