{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:27:44Z","timestamp":1791098864454,"version":"4.1.0"},"reference-count":42,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:p>Schwann cells elaborate myelin sheaths around axons by spirally wrapping and compacting their plasma membranes. Although actin remodeling plays a crucial role in this process, the effectors that modulate the Schwann cell cytoskeleton are poorly defined. Here, we show that the actin cytoskeletal regulator, neural Wiskott-Aldrich syndrome protein (N-WASp), is upregulated in myelinating Schwann cells coincident with myelin elaboration. When N-WASp is conditionally deleted in Schwann cells at the onset of myelination, the cells continue to ensheath axons but fail to extend processes circumferentially to elaborate myelin. Myelin-related gene expression is also severely reduced in the N-WASp-deficient cells and in vitro process and lamellipodia formation are disrupted. Although affected mice demonstrate obvious motor deficits these do not appear to progress, the mutant animals achieving normal body weights and living to advanced age. Our observations demonstrate that N-WASp plays an essential role in Schwann cell maturation and myelin formation.<\/jats:p>","DOI":"10.1242\/dev.058677","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T15:10:26Z","timestamp":1299597026000},"page":"1329-1337","source":"Crossref","is-referenced-by-count":64,"title":["N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination"],"prefix":"10.1242","volume":"138","author":[{"given":"Fuzi","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Haematology, Xijing Hospital, Fourth Military Medical University, Xi'an, China"},{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Haematology, Xijing Hospital, Fourth Military Medical University, Xi'an, China"},{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Bharioke","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Qiu","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lommel","sequence":"additional","affiliation":[{"name":"Institute for Cell Biology, University of Bonn, Ulrich-Haberland-Str. 61A, 53121 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Laura","family":"Feltri","sequence":"additional","affiliation":[{"name":"Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Wrabetz","sequence":"additional","affiliation":[{"name":"Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Roder","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Eyer","sequence":"additional","affiliation":[{"name":"Laboratory Neurobiologie et Transgenese, UPRES-EA3143, INSERM, Centre Hospitalier Universitaire, 49033 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiequn","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Xijing Hospital, Fourth Military Medical University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, Royal Victoria Hospital, MUHC, McGill University, Montreal, QC H3A 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Siminovitch","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Samuel Lunenfeld and Toronto General Research Institutes, 600 University Avenue, Toronto, ON M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042607153951100_R1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/glia.20505","article-title":"N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination","volume":"55","author":"Bacon","year":"2007","journal-title":"Glia"},{"key":"2021042607153951100_R2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20030976","article-title":"Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation","volume":"199","author":"Badour","year":"2004","journal-title":"J. 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