{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:53:40Z","timestamp":1791071620899,"version":"4.1.0"},"reference-count":78,"publisher":"The Company of Biologists","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:p>Primary cilia have essential functions in vertebrate development and signaling. However, little is known about cilia function in brain morphogenesis, a process that is severely affected in human ciliopathies. Here, we study telencephalic morphogenesis in a mouse mutant for the ciliopathy gene Ftm (Rpgrip1l). We show that the olfactory bulbs are present in an ectopic location in the telencephalon of Ftm\u2212\/\u2212 fetuses and do not display morphological outgrowth at the end of gestation. Investigating the developmental origin of this defect, we have established that E12.5 Ftm\u2212\/\u2212 telencephalic neuroepithelial cells lack primary cilia. Moreover, in the anterior telencephalon, the subpallium is expanded at the expense of the pallium, a phenotype reminiscent of Gli3 mutants. This phenotype indeed correlates with a decreased production of the short form of the Gli3 protein. Introduction of a Gli3 mutant allele encoding the short form of Gli3 into Ftm mutants rescues both telencephalic patterning and olfactory bulb morphogenesis, despite the persistence of cilia defects. Together, our results show that olfactory bulb morphogenesis depends on primary cilia and that the essential role of cilia in this process is to produce processed Gli3R required for developmental patterning. Our analysis thus provides the first in vivo demonstration that primary cilia control a developmental process via production of the short, repressor form of Gli3. Moreover, our findings shed light on the developmental origin of olfactory bulb agenesis and of other brain morphogenetic defects found in human diseases affecting the primary cilium.<\/jats:p>","DOI":"10.1242\/dev.059808","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:46:14Z","timestamp":1302741974000},"page":"2079-2088","source":"Crossref","is-referenced-by-count":101,"title":["Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing"],"prefix":"10.1242","volume":"138","author":[{"given":"Laurianne","family":"Besse","sequence":"first","affiliation":[{"name":"CNRS UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"UPMC Universit\u00e9 Paris 06 UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"INSERM U969, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariame","family":"Neti","sequence":"additional","affiliation":[{"name":"CNRS UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"UPMC Universit\u00e9 Paris 06 UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"INSERM U969, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Anselme","sequence":"additional","affiliation":[{"name":"CNRS UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"UPMC Universit\u00e9 Paris 06 UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"INSERM U969, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gerhardt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Entwicklungs und Molekularbiologie der Tiere (EMT), Heinrich-Heine-Universit\u00e4t, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"R\u00fcther","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Entwicklungs und Molekularbiologie der Tiere (EMT), Heinrich-Heine-Universit\u00e4t, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Laclef","sequence":"additional","affiliation":[{"name":"CNRS UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"UPMC Universit\u00e9 Paris 06 UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"INSERM U969, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Schneider-Maunoury","sequence":"additional","affiliation":[{"name":"CNRS UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"UPMC Universit\u00e9 Paris 06 UMR 7622, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"},{"name":"INSERM U969, 9 Quai Saint Bernard, Bo\u00eete 24, F-75005, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606524342900_R1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00005072-199011000-00007","article-title":"A distinctive triad of malformations of the central nervous system in the Meckel-Gruber syndrome","volume":"49","author":"Ahdab-Barmada","year":"1990","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2021042606524342900_R2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1096-9861(19970310)379:2<171::AID-CNE1>3.0.CO;2-0","article-title":"Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway","volume":"379","author":"Anchan","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2021042606524342900_R3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2006.12.025","article-title":"Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes","volume":"304","author":"Anselme","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1006\/dbio.2002.0811","article-title":"Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud","volume":"251","author":"Aoto","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ng2069","article-title":"Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome","volume":"39","author":"Arts","year":"2007","journal-title":"Nat. Genet."},{"key":"2021042606524342900_R6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1086\/519494","article-title":"Pleiotropic effects of CEP290 (NPHP6) mutations extend to Meckel syndrome","volume":"81","author":"Baala","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2021042606524342900_R7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.genom.7.080505.115610","article-title":"The ciliopathies: an emerging class of human genetic disorders","volume":"7","author":"Badano","year":"2006","journal-title":"Annu. Rev. Genomics Hum. 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Neurol."},{"key":"2021042606524342900_R11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/dvdy.20582","article-title":"Noses and neurons: induction, morphogenesis, and neuronal differentiation in the peripheral olfactory pathway","volume":"234","author":"Balmer","year":"2005","journal-title":"Dev. Dyn."},{"key":"2021042606524342900_R12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cne.10550","article-title":"Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding","volume":"457","author":"Bishop","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"2021042606524342900_R13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cne.20941","article-title":"Time frame of mitral cell development in the mice olfactory bulb","volume":"496","author":"Blanchart","year":"2006","journal-title":"J. Comp. 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Dyn."},{"key":"2021042606524342900_R17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.devcel.2007.03.004","article-title":"The graded response to Sonic hedgehog depends on cilia architecture","volume":"12","author":"Caspary","year":"2007","journal-title":"Dev. Cell"},{"key":"2021042606524342900_R18","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1523\/JNEUROSCI.5586-06.2007","article-title":"Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool","volume":"27","author":"Chizhikov","year":"2007","journal-title":"J. Neurosci."},{"key":"2021042606524342900_R19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/dbio.2001.0423","article-title":"Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras","volume":"239","author":"Cobos","year":"2001","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ydbio.2008.10.020","article-title":"Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122\/Wdr10, partially overlapping with the DNA repair gene Med1\/Mbd4","volume":"325","author":"Cortellino","year":"2009","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/(SICI)1096-9861(19981221)402:3<402::AID-CNE8>3.0.CO;2-0","article-title":"Olfactory bulb development is altered in small-eye (Sey) mice","volume":"402","author":"Dellovade","year":"1998","journal-title":"J. Comp. 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Neurosci."},{"key":"2021042606524342900_R28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nn1093","article-title":"Emx2 patterns the neocortex by regulating FGF positional signaling","volume":"6","author":"Fukuchi-Shimogori","year":"2003","journal-title":"Nat. Neurosci."},{"key":"2021042606524342900_R29","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1242\/dev.00416","article-title":"Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants","volume":"130","author":"Garel","year":"2003","journal-title":"Development"},{"key":"2021042606524342900_R30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0070-2153(08)00807-7","article-title":"Ciliary function and Wnt signal modulation","volume":"85","author":"Gerdes","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042606524342900_R31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cell.2009.03.023","article-title":"The vertebrate primary cilium in development, homeostasis, and disease","volume":"137","author":"Gerdes","year":"2009","journal-title":"Cell"},{"key":"2021042606524342900_R32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0896-6273(95)90243-0","article-title":"Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfactory bulb","volume":"14","author":"Gong","year":"1995","journal-title":"Neuron"},{"key":"2021042606524342900_R33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ydbio.2008.09.019","article-title":"Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain","volume":"325","author":"Gorivodsky","year":"2009","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nn2059","article-title":"Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells","volume":"11","author":"Han","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2021042606524342900_R35","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pgen.0010053","article-title":"Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function","volume":"1","author":"Haycraft","year":"2005","journal-title":"PLoS Genet."},{"key":"2021042606524342900_R36","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrn2463","article-title":"The genetics of early telencephalon patterning: some assembly required","volume":"9","author":"Hebert","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042606524342900_R37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/dev.00334","article-title":"FGF signaling through FGFR1 is required for olfactory bulb morphogenesis","volume":"130","author":"Hebert","year":"2003","journal-title":"Development"},{"key":"2021042606524342900_R38","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/hmg\/ddm156","article-title":"The molecular basis of Pallister Hall associated polydactyly","volume":"16","author":"Hill","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"2021042606524342900_R39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1242\/dev.02329","article-title":"Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously","volume":"133","author":"Hirata","year":"2006","journal-title":"Development"},{"key":"2021042606524342900_R40","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1242\/dev.029835","article-title":"C2cd3 is required for cilia formation and Hedgehog signaling in mouse","volume":"135","author":"Hoover","year":"2008","journal-title":"Development"},{"key":"2021042606524342900_R41","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.1073\/pnas.0505328102","article-title":"Cilia and Hedgehog responsiveness in the mouse","volume":"102","author":"Huangfu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. 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Neurol."},{"key":"2021042606524342900_R45","first-page":"543","article-title":"Extra-toes: anew mutant gene causing multiple abnormalities in the mouse","volume":"17","author":"Johnson","year":"1967","journal-title":"J. Embryol. Exp. Morphol."},{"key":"2021042606524342900_R46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/humu.9489","article-title":"Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation","volume":"28","author":"Khaddour","year":"2007","journal-title":"Hum. Mutat."},{"key":"2021042606524342900_R47","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0012-1606(03)00252-5","article-title":"A disrupted balance between Bmp\/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon","volume":"260","author":"Kuschel","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0006-3223(99)00002-5","article-title":"Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice","volume":"46","author":"LaMantia","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"2021042606524342900_R49","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"2021042606524342900_R50","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1523\/JNEUROSCI.23-02-00568.2003","article-title":"DLX5 regulates development of peripheral and central components of the olfactory system","volume":"23","author":"Long","year":"2003","journal-title":"J. Neurosci."},{"key":"2021042606524342900_R51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.neuro.26.041002.131058","article-title":"Cell migration in the forebrain","volume":"26","author":"Marin","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"2021042606524342900_R52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(08)00801-6","article-title":"Basal bodies platforms for building cilia","volume":"85","author":"Marshall","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042606524342900_R53","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ydbio.2005.08.050","article-title":"Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli","volume":"287","author":"May","year":"2005","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R54","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0012-1606(03)00065-4","article-title":"The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord","volume":"257","author":"Meyer","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042606524342900_R55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng0298-136","article-title":"An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination","volume":"18","author":"Meyers","year":"1998","journal-title":"Nat. Genet."},{"key":"2021042606524342900_R56","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0012-1606(03)00159-3","article-title":"Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification","volume":"259","author":"Motoyama","year":"2003","journal-title":"Dev. 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