{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:57:30Z","timestamp":1792717050646,"version":"4.5.0"},"reference-count":67,"publisher":"The Company of Biologists","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p>The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.<\/jats:p>","DOI":"10.1242\/dev.063834","type":"journal-article","created":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T11:39:01Z","timestamp":1307446741000},"page":"2783-2792","source":"Crossref","is-referenced-by-count":194,"title":["Evolutionary plasticity of segmentation clock networks"],"prefix":"10.1242","volume":"138","author":[{"given":"Aur\u00e9lie J.","family":"Krol","sequence":"first","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"},{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Universit\u00e9 de Strasbourg, Illkirch F-67400, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Roellig","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Lee","family":"Dequ\u00e9ant","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tassy","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"},{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Universit\u00e9 de Strasbourg, Illkirch F-67400, France"},{"name":"Howard Hughes Medical Institute, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Glynn","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaye","family":"Hattem","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcady","family":"Mushegian","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Oates","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pourqui\u00e9","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"},{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Universit\u00e9 de Strasbourg, Illkirch F-67400, France"},{"name":"Howard Hughes Medical Institute, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606561067000_R1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2021042606561067000_R2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/dbio.1998.9164","article-title":"Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation","volume":"207","author":"Aulehla","year":"1999","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R3","doi-asserted-by":"crossref","first-page":"12195","DOI":"10.1073\/pnas.2134310100","article-title":"Sp8 is crucial for limb outgrowth and neuropore closure","volume":"100","author":"Bell","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606561067000_R4","doi-asserted-by":"crossref","first-page":"27018","DOI":"10.1074\/jbc.271.43.27018","article-title":"The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase","volume":"271","author":"Beltman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021042606561067000_R5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav. Brain Res."},{"key":"2021042606561067000_R6","doi-asserted-by":"crossref","first-page":"D263","DOI":"10.1093\/nar\/gkm1020","article-title":"InParanoid 6, eukaryotic ortholog clusters with inparalogs","volume":"36","author":"Berglund","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R7","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1092303","article-title":"Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock","volume":"17","author":"Bessho","year":"2003","journal-title":"Genes Dev."},{"key":"2021042606561067000_R8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/0-387-29362-0_3","article-title":"Quality assessment of Affymetrix GeneChip data in bioinformatics and computational biology solutions using R and Bioconductor","volume-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","author":"Bolstad","year":"2005"},{"key":"2021042606561067000_R9","doi-asserted-by":"crossref","first-page":"D724","DOI":"10.1093\/nar\/gkm961","article-title":"The Mouse Genome Database (MGD): mouse biology and model systems","volume":"36","author":"Bult","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/BC20080136","article-title":"FGF signalling modulates transcriptional repression by Xenopus groucho-related-4","volume":"101","author":"Burks","year":"2009","journal-title":"Biol. Cell"},{"key":"2021042606561067000_R11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ydbio.2008.02.038","article-title":"The segmentation cascade in the centipede Strigamia maritima: involvement of the Notch pathway and pair-rule gene homologues","volume":"319","author":"Chipman","year":"2008","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R12","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1074\/jbc.271.11.6497","article-title":"The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation","volume":"271","author":"Chu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021042606561067000_R13","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1101\/gr.2334104","article-title":"Functional proteomics mapping of a human signaling pathway","volume":"14","author":"Colland","year":"2004","journal-title":"Genome Res."},{"key":"2021042606561067000_R14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.devcel.2006.02.011","article-title":"Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis","volume":"10","author":"Dale","year":"2006","journal-title":"Dev. Cell"},{"key":"2021042606561067000_R15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1126\/science.1113832","article-title":"Gene regulatory networks and the evolution of animal body plans","volume":"311","author":"Davidson","year":"2006","journal-title":"Science"},{"key":"2021042606561067000_R16","doi-asserted-by":"crossref","first-page":"19201","DOI":"10.1074\/jbc.M710366200","article-title":"Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1","volume":"283","author":"Dehner","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021042606561067000_R17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrg2320","article-title":"Segmental patterning of the vertebrate embryonic axis","volume":"9","author":"Dequeant","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"2021042606561067000_R18","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1126\/science.1133141","article-title":"A complex oscillating network of signaling genes underlies the mouse segmentation clock","volume":"314","author":"Dequeant","year":"2006","journal-title":"Science"},{"key":"2021042606561067000_R19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.modgep.2004.02.003","article-title":"her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes)","volume":"4","author":"Elmasri","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"2021042606561067000_R20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.hdy.6800915","article-title":"Robustness and evolution: concepts, insights and challenges from a developmental model system","volume":"100","author":"Felix","year":"2008","journal-title":"Heredity"},{"key":"2021042606561067000_R21","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1242\/dev.128.12.2175","article-title":"sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish","volume":"128","author":"Furthauer","year":"2001","journal-title":"Development"},{"key":"2021042606561067000_R22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ydbio.2007.03.028","article-title":"Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings","volume":"306","author":"Furushima","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ydbio.2009.02.035","article-title":"Interfering with Wnt signalling alters the periodicity of the segmentation clock","volume":"330","author":"Gibb","year":"2009","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R24","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/bioinformatics\/bti789","article-title":"Detecting periodic patterns in unevenly spaced gene expression time series using Lomb-Scargle periodograms","volume":"22","author":"Glynn","year":"2006","journal-title":"Bioinformatics"},{"key":"2021042606561067000_R25","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jtbi.2008.01.006","article-title":"Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways","volume":"252","author":"Goldbeter","year":"2008","journal-title":"J. Theor. Biol."},{"key":"2021042606561067000_R26","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1242\/dev.125.17.3379","article-title":"Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes","volume":"125","author":"Griffin","year":"1998","journal-title":"Development"},{"key":"2021042606561067000_R27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ydbio.2007.07.031","article-title":"The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus","volume":"310","author":"Guemar","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo","volume":"195","author":"Hamburger","year":"1992","journal-title":"Dev. Dyn."},{"key":"2021042606561067000_R29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/375787a0","article-title":"Expression of a Delta homologue in prospective neurons in the chick","volume":"375","author":"Henrique","year":"1995","journal-title":"Nature"},{"key":"2021042606561067000_R30","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.129.15.3693","article-title":"Two linked hairy\/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries","volume":"129","author":"Henry","year":"2002","journal-title":"Development"},{"key":"2021042606561067000_R31","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1101\/gad.14.13.1678","article-title":"Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity","volume":"14","author":"Holley","year":"2000","journal-title":"Genes Dev."},{"key":"2021042606561067000_R32","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1073\/pnas.0812880106","article-title":"FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1","volume":"106","author":"Hong","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606561067000_R33","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkn828","article-title":"Ensembl 2009","volume":"37","author":"Hubbard","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R34","first-page":"837","article-title":"Altered expression of helix-loop-helix transcriptional regulators and cyclin D1 in Wnt-1-transformed PC12 cells","volume":"9","author":"Issack","year":"1998","journal-title":"Cell Growth Differ."},{"key":"2021042606561067000_R35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nature05186","article-title":"Co-evolution of transcriptional and post-translational cell-cycle regulation","volume":"443","author":"Jensen","year":"2006","journal-title":"Nature"},{"key":"2021042606561067000_R36","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/35044091","article-title":"Notch signalling and the synchronization of the somite segmentation clock","volume":"408","author":"Jiang","year":"2000","journal-title":"Nature"},{"key":"2021042606561067000_R37","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1242\/dev.127.7.1421","article-title":"Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm","volume":"127","author":"Jouve","year":"2000","journal-title":"Development"},{"key":"2021042606561067000_R38","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkp896","article-title":"KEGG for representation and analysis of molecular networks involving diseases and drugs","volume":"38","author":"Kanehisa","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R39","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1158\/0008-5472.CAN-08-3232","article-title":"Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression","volume":"69","author":"Kumar","year":"2009","journal-title":"Cancer Res."},{"key":"2021042606561067000_R40","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1242\/dev.00449","article-title":"Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling","volume":"130","author":"Latinkic","year":"2003","journal-title":"Development"},{"key":"2021042606561067000_R41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/dbio.2000.9884","article-title":"Oscillating expression of c-hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors","volume":"227","author":"Leimeister","year":"2000","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R42","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0960-9822(03)00534-7","article-title":"Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator","volume":"13","author":"Lewis","year":"2003","journal-title":"Curr. Biol."},{"key":"2021042606561067000_R43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1432-0436.2003.700608.x","article-title":"Cyclic expression of esr9 gene in Xenopus presomitic mesoderm","volume":"71","author":"Li","year":"2003","journal-title":"Differentiation"},{"key":"2021042606561067000_R44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2004.04.016","article-title":"Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta","volume":"222","author":"Liu","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021042606561067000_R45","doi-asserted-by":"crossref","first-page":"D26","DOI":"10.1093\/nar\/gkl993","article-title":"Entrez Gene: gene-centered information at NCBI","volume":"35","author":"Maglott","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2199-9-102","article-title":"Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment","volume":"9","author":"McCurley","year":"2008","journal-title":"BMC Mol. Biol."},{"key":"2021042606561067000_R47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0960-9822(98)70401-4","article-title":"The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos","volume":"8","author":"McGrew","year":"1998","journal-title":"Curr. Biol."},{"key":"2021042606561067000_R48","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1101\/gad.495308","article-title":"Intraspecific evolution of the intercellular signaling network underlying a robust developmental system","volume":"22","author":"Milloz","year":"2008","journal-title":"Genes Dev."},{"key":"2021042606561067000_R49","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.1191937","article-title":"Oscillating gene expression determines competence for periodic Arabidopsis root branching","volume":"329","author":"Moreno-Risueno","year":"2010","journal-title":"Science"},{"key":"2021042606561067000_R50","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1242\/dev.129.12.2929","article-title":"Hairy\/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta\/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish","volume":"129","author":"Oates","year":"2002","journal-title":"Development"},{"key":"2021042606561067000_R51","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1073\/pnas.0909375107","article-title":"Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation","volume":"107","author":"Ozbudak","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606561067000_R52","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis","volume":"91","author":"Palmeirim","year":"1997","journal-title":"Cell"},{"key":"2021042606561067000_R53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-60327-977-2_11","article-title":"Tissue micromanipulation in zebrafish embryos","volume":"546","author":"Picker","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"2021042606561067000_R54","doi-asserted-by":"crossref","first-page":"16614","DOI":"10.1073\/pnas.0804093105","article-title":"Ancestral Notch-mediated segmentation revealed in the cockroach Periplaneta americana","volume":"105","author":"Pueyo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042606561067000_R55","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ydbio.2007.01.004","article-title":"Completing the set of h\/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock","volume":"304","author":"Shankaran","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042606561067000_R56","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00427-004-0427-z","article-title":"her11 is involved in the somitogenesis clock in zebrafish","volume":"214","author":"Sieger","year":"2004","journal-title":"Dev. Genes Evol."},{"key":"2021042606561067000_R57","doi-asserted-by":"crossref","first-page":"D581","DOI":"10.1093\/nar\/gkj086","article-title":"The Zebrafish Information Network: the zebrafish model organism database","volume":"34","author":"Sprague","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R58","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1074\/mcp.M700120-MCP200","article-title":"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction","volume":"6","author":"Tang","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"2021042606561067000_R59","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1745-7270.2007.00283.x","article-title":"Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT-PCR normalization","volume":"39","author":"Tang","year":"2007","journal-title":"Acta Biochem. Biophys. Sinica"},{"key":"2021042606561067000_R60","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/dev.119.4.1203","article-title":"Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos","volume":"119","author":"Thisse","year":"1993","journal-title":"Development"},{"key":"2021042606561067000_R61","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1242\/dev.01733","article-title":"Wnt\/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish","volume":"132","author":"Thorpe","year":"2005","journal-title":"Development"},{"key":"2021042606561067000_R62","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.bbadis.2006.07.010","article-title":"ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells","volume":"1762","author":"Traina","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042606561067000_R63","doi-asserted-by":"crossref","first-page":"D88","DOI":"10.1093\/nar\/gkm964","article-title":"DBD-taxonomically broad transcription factor predictions: new content and functionality","volume":"36","author":"Wilson","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021042606561067000_R64","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/dvdy.22139","article-title":"Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate","volume":"238","author":"Wright","year":"2009","journal-title":"Dev. Dyn."},{"key":"2021042606561067000_R65","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","article-title":"GoMiner: a resource for biological interpretation of genomic and proteomic data","volume":"4","author":"Zeeberg","year":"2003","journal-title":"Genome Biol."},{"key":"2021042606561067000_R66","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.015073","article-title":"Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways","volume":"135","author":"Zhao","year":"2008","journal-title":"Development"},{"key":"2021042606561067000_R67","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/ncb1727","article-title":"The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein","volume":"10","author":"Zhao","year":"2008","journal-title":"Nat. Cell Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/13\/2783\/1193944\/2783.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/138\/13\/2783\/1193944\/2783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T18:38:43Z","timestamp":1637779123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/138\/13\/2783\/44467\/Evolutionary-plasticity-of-segmentation-clock"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":67,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.063834","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}