{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:39:16Z","timestamp":1792089556559,"version":"4.4.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p>Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis-segregation. Aurora kinase B interacts with survivin, borealin and incenp to form the chromosomal passenger complex (CPC), which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. Whereas genetic ablation of survivin, borealin or incenp results in early lethality at the morula stage, we show here that aurora B is dispensable for CPC function during early cell divisions and aurora B-null embryos are normally implanted. This is due to a crucial function of aurora C during these early embryonic cycles. Expression of aurora C decreases during late blastocyst stages resulting in post-implantation defects in aurora B-null embryos. These defects correlate with abundant prometaphase figures and apoptotic cell death of the aurora B-deficient inner cell mass. Conditional deletion of aurora B in somatic cells that do not express aurora C results in chromosomal misalignment and lack of chromosome segregation. Re-expression of wild-type, but not kinase-dead, aurora C rescues this defect, suggesting functional overlap between these two kinases. Finally, aurora B-null cells partially arrest in the presence of nocodazole, suggesting that this kinase is not essential for the spindle assembly checkpoint.<\/jats:p>","DOI":"10.1242\/dev.066381","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T02:48:54Z","timestamp":1306378134000},"page":"2661-2672","source":"Crossref","is-referenced-by-count":99,"title":["Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development"],"prefix":"10.1242","volume":"138","author":[{"given":"Gonzalo","family":"Fern\u00e1ndez-Miranda","sequence":"first","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Trakala","sequence":"additional","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Transgenic Mice Unit, CNIO, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Escobar","sequence":"additional","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert B.","family":"Ghyselinck","sequence":"additional","affiliation":[{"name":"Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagrario","family":"Ortega","sequence":"additional","affiliation":[{"name":"Transgenic Mice Unit, CNIO, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ca\u00f1amero","sequence":"additional","affiliation":[{"name":"Comparative Pathology Unit, CNIO, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio P\u00e9rez","family":"de Castro","sequence":"additional","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Malumbres","sequence":"additional","affiliation":[{"name":"Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606551320100_R1","doi-asserted-by":"crossref","first-page":"29424","DOI":"10.1074\/jbc.M802475200","article-title":"Regulation of postsynaptic RapGAP SPAR by polo-like kinase 2 and the SCF\u00ce2-TRCP ubiquitin ligase in hippocampal neurons","volume":"283","author":"Ang","year":"2008","journal-title":"J. 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