{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:09:05Z","timestamp":1790935745468,"version":"4.1.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:p>Mutations in TRPS1 cause trichorhinophalangeal syndrome types I and III, which are characterized by sparse scalp hair in addition to craniofacial and skeletal abnormalities. Trps1 is a vertebrate transcription factor that contains nine zinc-finger domains, including a GATA-type zinc finger through which it binds DNA. Mice in which the GATA domain of Trps1 has been deleted (Trps1\u0394gt\/\u0394gt) have a reduced number of pelage follicles and lack vibrissae follicles postnatally. To identify the transcriptional targets of Trps1 in the developing vibrissa follicle, we performed microarray hybridization analysis, comparing expression patterns in the whisker pads of wild-type versus Trps1\u0394gt\/\u0394gt embryos. We identified a number of transcription factors and Wnt inhibitors among transcripts downregulated in the mutant embryos and several extracellular matrix proteins that were upregulated in the mutant samples, and demonstrated that target gene expression levels were altered in vivo in Trps1\u0394gt\/\u0394gt vibrissae. Unexpectedly, we discovered that Trps1 can directly bind the promoters of its target genes to activate transcription, expanding upon its established role as a transcriptional repressor. Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle.<\/jats:p>","DOI":"10.1242\/dev.069971","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T03:31:52Z","timestamp":1322191912000},"page":"203-214","source":"Crossref","is-referenced-by-count":61,"title":["Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis"],"prefix":"10.1242","volume":"139","author":[{"given":"Katherine A.","family":"Fantauzzo","sequence":"first","affiliation":[{"name":"Department of Dermatology and Department of Genetics and Development, Columbia University, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Christiano","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Department of Genetics and Development, Columbia University, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042606180810700_R1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1534-5807(02)00167-3","article-title":"WNT signals are required for the initiation of hair follicle development","volume":"2","author":"Andl","year":"2002","journal-title":"Dev. 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